2015
DOI: 10.1007/s00604-015-1559-8
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Sensing glucose based on its affinity for concanavalin A on a glassy carbon electrode modified with a C60 fullerene nanocomposite

Abstract: An ultrasensitive electrochemical glucose biosensor has been developed by depositing C 60 -fullerene functionalized with tetraoctylammonium bromide (C 60 -TOAB + ) on the surface of a glassy carbon electrode (GCE). The glucosebinding protein concanavalin A (Con A) was then linked to the surface. Binding of glucose by Con A affects the electroactivity of the reversible redox couple C 60 /C 60 − , and this finding forms the basis for a quantitative glucose assay over the 10 to 10 mM concentration range and with … Show more

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Cited by 20 publications
(7 citation statements)
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“…The development of simple, reliable, cost efficient, and rapid glucose-monitoring devices has been effectively driven by rising demand in personal health care, diagnosis and management of diabetes mellitus, control of bioprocess, pharmaceutical analysis, and ecological and food monitoring. , An enzyme-free electrochemical glucose sensor (EFGS) is considered as the most convenient and effective tool as it provides the constructive features including excellent sensitivity, simple instrumentation, easy operation, low production cost, good reproducibility, and anti-interference abilities. , In general, EFGS is constructed with solid current collectors including glassy carbon electrode (GCE), platinum (Pt), and gold (Au) . However, the aforementioned electrodes require laborious polishing and modification procedures, which not only increase the cost of a sensor device but also preclude their practical utility.…”
Section: Introductionmentioning
confidence: 99%
“…The development of simple, reliable, cost efficient, and rapid glucose-monitoring devices has been effectively driven by rising demand in personal health care, diagnosis and management of diabetes mellitus, control of bioprocess, pharmaceutical analysis, and ecological and food monitoring. , An enzyme-free electrochemical glucose sensor (EFGS) is considered as the most convenient and effective tool as it provides the constructive features including excellent sensitivity, simple instrumentation, easy operation, low production cost, good reproducibility, and anti-interference abilities. , In general, EFGS is constructed with solid current collectors including glassy carbon electrode (GCE), platinum (Pt), and gold (Au) . However, the aforementioned electrodes require laborious polishing and modification procedures, which not only increase the cost of a sensor device but also preclude their practical utility.…”
Section: Introductionmentioning
confidence: 99%
“…Besides carbon nanotubes [ 18 ], graphene [ 19 ], and fullerenes [ 20 ], ordered mesoporous carbons (OMC) are often tested as components of novel biosensors. Among OMC, the most frequent CMK-3 and CMK-1 are employed for biosensor matrix preparation.…”
Section: Introductionmentioning
confidence: 99%
“…After being incorporated in TOAB film, as shown in Fig. b, the morphology of TOAB/CoTPPS 4 /C 60 became more even distributed and exhibited much smaller microarray‐like structures, which helps enhancing the electron transfer rate of CoTPPS 4 /C 60 . Likewise, the composites of TOAB/ZnTPPS 4 /C 60 and TOAB/FeTPPS 4 /C 60 also showed the similar trend of morphology in contrast to ZnTPPS 4 /C 60 and FeTPPS 4 /C 60 (seen in Fig.…”
Section: Resultsmentioning
confidence: 96%