Sensitive High-Performance Liquid Chromatographic Determination of Mebeverine in Plasma Using Fluorescence Detection

Potentiometric flow injection analysis of mebeverine hydrochloride in serum and urine

“…The reported methods for the determination of mebeverine, in the main, are chromatographic which, in spite of their good sensitivities, are very expensive, time consuming and require special training. They include high performance liquid chromatography [3][4][5][6], online micellar electrokinetic chromatography [7], highperformance thin layer chromatography [8,9], supercriticalfluid chromatography-mass spectrometry [10], and online reversed-phase liquid chromatography-gas chromatography [11]. Other alternatives include, spectrophotometry [12][13][14][15] and first-derivative UV-spectrophotometry [16].…”

Improving the detection limits of antispasmodic drugs electrodes by using modified membrane sensors with inner solid contact

“…They have been used for treatment of irritable bowel syndrome, gastrointestinal diseases, biliary dyskinesia, nephrolithiasis, gynecologiicial diseases and vasomotor diseases associated with smooth muscle spasms [10]. The reported methods for determination of the antispasmodic drugs; dicyclomine [11,12], mebeverine [13,14] and drotaverine [15,16] are mainly chromatographic, which in spite of their high sensitivities, are very expensive, involve the use of complex procedures with several sample manipulations and requiring long analysis time.…”

Potentiometric determination of mebeverine hydrochloride antispasmodic drug based on molecular docking with different ionophores host–guest inclusion as a theoretical study

“…A comprehensive study of the literature revealed the dominance of analytical methods for MBV, including spectrophotometric, 2–11 HPLC, 12–18 fluorometric, 19,20 and electrochemical methods. 21–27 Although these methods provided a high level of specificity, they are unable to apply rapid in situ detection of MBV.…”