Sentinel Lymph Node Biopsy in Head and Neck Squamous Cell Carcinoma

Pitman, Karen T.; Johnson, Jonas T.; Brown, Manuel L.; Myers, Eugene N.

doi:10.1097/00005537-200212000-00001

Cited by 87 publications

(44 citation statements)

References 43 publications

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“…Taylor et al 20 reported an SN identification rate of 89% at lymphoscintigraphy in nine patients with T2N0 oral or oropharyngeal cancer Another study by Mozilla et al 23 showed SN visualization in 95% of 41 patients. Pitman et al 27 also demonstrated a 95% identification rate in 20 patients with oral cancer. On the other hand, Koch et al 14 identified SNs at lymphoscintigraphy with use of radiolabeled colloid alone in only two of five patients with SCC in the oral cavity.…”

Section: Discussionmentioning

confidence: 92%

Histopathologic validation of the sentinel node concept in oral and oropharyngeal squamous cell carcinoma

et al. 2005

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Section: Discussionmentioning

confidence: 92%

Histopathologic validation of the sentinel node concept in oral and oropharyngeal squamous cell carcinoma

et al. 2005

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“…The accuracy of the technique is, however, reported as 90% to 100% in most of these small series. [4][5][6][7] Data collected from 22 centers were reported at the first international conference on SNB in HNSCC. 8 The conclusion was that SNB is an accurate technique in centers that performed more than 10 cases of SNB.…”

mentioning

confidence: 99%

Lymphoscintigraphy for sentinel node mapping using a hybrid single photon emission CT (SPECT)/CT system in oral cavity squamous cell carcinoma

et al. 2006

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“…They amended the study after initial 9 cases and included patients with clinically positive neck nodes. Still, no blue lymphatic channels or node were visualized after injection of 1 % isosulfan blue dye [13].…”

Section: Discussionmentioning

confidence: 92%

Sentinel Lymph Node Localization Using 1 % Isosulfan Blue Dye in Cases of Early Oral Cavity and Oropharyngeal Squamous Cell Carcinoma

Sangwan¹,

Nilakantan

Patnaik³

et al. 2014

Indian J Otolaryngol Head Neck Surg

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To study the use of 1 % isosulfan blue dye in identifying sentinel node, sensitivity and specificity of frozen section and predictive value of sentinel node in predicting other nodal status in the cases of oral cavity and oropharyngeal squamous cell carcinoma. 15 patients of oral cavity and oropharyngeal SCC with clinically N0 neck, who required WLE of the primary lesion as well as neck dissection as per recommended treatment protocol, were selected from OPD. 1 % Isosulfan dye was injected peritumorally intraoperatively after the induction of general anaesthesia. Neck dissection was performed and first node taking up the blue dye was identified, dissected, removed and was sent for frozen section. In two of the 15 cases a sentinel node was identified (sensitivity of the technique-13 %). Both the sentinel nodes were positive for presence of metastasis on final histopathology (specificity-100 %). However, five cases had nodal metastasis on final histopathological examination of the neck dissection specimen (sensitivity of sentinel lymph node biopsy-40 %). Frozen section examination had a sensitivity and specificity of 100 %. All data was analyzed using SPSS 16 software. Use of 1 % Isosulfan Dye for identification of sentinel node is a simple and cheap technique, however, it has low sensitivity as compared to the use of triple diagnostic procedure consisting of lymphoscintigraphy, per op gamma probe localization and using isosulfan dye for sentinel node identification. Sentinel lymph node is representative of nodal status and correlates well with the final histopathological examination of the dissected neck nodes.Keywords Sentinel node Á N0 neck Á Isosulfan blue dye Á Frozen section Á SLNB (sentinel lymph node biopsy)

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Sentinel Lymph Node Biopsy in Head and Neck Squamous Cell Carcinoma

Cited by 87 publications

References 43 publications

Histopathologic validation of the sentinel node concept in oral and oropharyngeal squamous cell carcinoma

Histopathologic validation of the sentinel node concept in oral and oropharyngeal squamous cell carcinoma

Lymphoscintigraphy for sentinel node mapping using a hybrid single photon emission CT (SPECT)/CT system in oral cavity squamous cell carcinoma

Sentinel Lymph Node Localization Using 1 % Isosulfan Blue Dye in Cases of Early Oral Cavity and Oropharyngeal Squamous Cell Carcinoma

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