Separate and combined associations of physical activity and obesity with lipid-related indices in non-diabetic and diabetic patients

Abstract

BackgroundThis study evaluated the separate and combined associations of physical activity and obesity with blood lipids in Chinese adults with and without diabetes.MethodsData of 17,535 participants aged 18 to 78 years old were collected. Physical activity was categorized as inactive (low) or active (moderate or high) according to the International Physical Activity Questionnaire. Linear and logistic regression analyses were performed to investigate the associations of physical activity and obesity with lipid-related indices.ResultsCompared with physically active participants, inactive participants had higher triglyceride (TG) level, lower high-density lipoprotein cholesterol (HDL-C) level, and higher odds ratios for abnormal TG and HDL-C. Compared with non-obese participants, obese participants had higher levels of total cholesterol (TC), TG and low-density lipoprotein cholesterol (LDL-C), lower HDL-C level, and higher odds ratios for the four abnormal lipid indices. Inactive obese participants had highest levels of TC, TG and LDL-C, lowest HDL-C level, and highest odds ratios compared to the other groups. No significant associations were found between obesity and TC, LDL-C in patients with diabetes.ConclusionsIrrespective of diabetes, physical inactivity and obesity were associated with the presences of abnormal TG and HDL-C. Moreover, there were additive effects on blood lipids when physical inactivity and obesity co-occur.

Anti-Obesity Effects of Lactobacillus fermentum CQPC05 Isolated from Sichuan Pickle in High-Fat Diet-Induced Obese Mice through PPAR-α Signaling Pathway

“…ALT and AST are mainly distributed in hepatocytes. During hepatocyte necrosis, ALT and AST are released into the blood circulation, which increases the level of serum enzymes and coincides with the degree of hepatocyte injury, resulting in their indices being the most effective, at present, for measuring liver function [33]. Given that blood lipid content can reflect the state of systemic lipid metabolism, abnormal blood lipids (e.g., TG, TC, HDL-C, and LDL-C) are one of the most common markers of metabolic syndrome [34].…”

Regulating effect ofLactobacillus plantarumCQPC03 on lipid metabolism in high‐fat diet‐induced obesity in mice

“…In our study, ingesting excess energy significantly raised the levels of TG, TC, and LDL-C and decreased that of HDL-C in both the serum and the liver. necrosis (Panelli et al, 2018;Zhang et al, 2019). As shown in Tables 5 and 6, ingesting excess energy harms the hepatic function, and LP-CQPC03 can efficiently protect the liver from these harming effects.…”

“…ALT, AST, and AKP are important diagnostic enzymes, reflecting liver function and degree of cell damage. These enzymes are mainly present in the hepatocytes and are released into the circulation during hepatocytic necrosis (Panelli et al., 2018; Zhang et al., 2019). As shown in Tables 5 and 6, ingesting excess energy harms the hepatic function, and LP‐CQPC03 can efficiently protect the liver from these harming effects.…”

Inhibition of miR-27b Regulates Lipid Metabolism in Skeletal Muscle of Obese Rats During Hypoxic Exercise by Increasing PPARγ Expression

“…Obesity is often accompanied by dyslipidemia ( Zhang et al, 2019 ). Although regular exercise can improve blood lipid composition in obese people, the underlying mechanism is still unclear.…”