Sequence of Action of Genes at the Secretor, H, ABO and Lewis Loci

Boettcher, B.

doi:10.1159/000152994

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Watkins (1959), Watkins and Morgan (1959) and Ceppellini (1959) Lewis substances was secreted. The investigations made by these and other workers which followed showed that the genes were more likely to act in the order Sese, Hh, ABO and Lele (Boettcher, 1978), but the possibility apparently also exists that independent recessive suppressor genes inherited in double dose may alter the a-2-L-fucosyltransferase expressed by normally-inhertied H genes in 0h individuals (Watkins, 1980).…”

Section: Discussionmentioning

confidence: 89%

Preface and Acknowledgements

Garrison¹,

Aiello²,

Moore³

1999

Late Cenozoic Fluid Seeps and Tectonics Along the San Gregorio Fault Zone in the Monterey Bay Region, California

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INDIANS 50 5.1 fNTRODUCTl ON 50 5.2 CASE HISTORIES 52 5.3 MA TERIALS AND METHODS 53 5.4 RESULTS 53 5.4.1 First Natal Indian family with Category 2 or phenotype Bm red cells (Moores, 1970) 5.4.1.1 Family study and discussion 5.4.2 Second Natal Indian family with Category 2 or phenotype Bm red cells 60 5.4.2 .1 Family study and discussion 5.4.3 Four Natal Indian individuals with Category 2 -or phenotype Bm-like red cells; phenotype study 5.4.4 Two Natal Indian individuals with Ca tegory 3 -or phenotype B3 -like red cells; phenotype study 5.4.5 Category 3 -or phenotype B3 -like red cells; discussion

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Section: Discussionmentioning

confidence: 89%

Preface and Acknowledgements

Garrison¹,

Aiello²,

Moore³

1999

Late Cenozoic Fluid Seeps and Tectonics Along the San Gregorio Fault Zone in the Monterey Bay Region, California

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“…The presence of the antigens in aqueous body fluids, a dominant genetically controlled character, depends on the synthesis of the H antigen. In non-secretors, the H antigen is not synthesized and, although the A or B genes may be active, little A or B antigen is expressed (2).…”

Section: Introductionmentioning

confidence: 99%

Conversion of the human blood group H antigen to A antigen in vitro

Yang

Boettcher

1991

Immunology & Cell Biology

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A-transferase (N-acetylgalactosaminyl transferase) was purified from human group A plasma using Sepharose 4B affinity chromatography. Human anti-A antibodies were purified from human serum by adsorption to an immunosorbent column and heat elution in order to detect the A antigen. Conditions appropriate for the development of the A antigen on O red cells were examined and several buffer systems were found to be equally effective. Expression of the developed A antigen was found to be similar to that on group A red cells, indicating that the system in vitro has similar activity to the system in vivo. The H antigen from human saliva was coupled to Sepharose 4B or adsorbed to a nitrocellulose membrane. The A antigen was able to be developed on these materials by the action of group A-transferase. The procedures enabled the identification in vitro of sugar-transferase activities which can be useful in studies within the A,B,H antigen system or other carbohydrate antigen system.

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