The search for quality in education involves the study, analysis and reflection of pedagogical strategies such as the Sequence of Teaching by Inquiry (SEI), leading the student to the critical development of the contents worked. This work aims at the application of a CES focused on the teaching and learning of the content of the Human Nervous System. Didactic strategies and educational games are methods that can involve the student in a new learning experience and that have been increasingly used in different areas of Education, favoring teaching compared to the more traditional method. This work was carried out with students of the 2nd year of a high school, located in the municipality of Tianguá, where semi-structured questionnaires were applied, dynamics, classes and a sequence of teaching by investigation (SEI) were carried out in the search for a greater interaction of students with the content and the promotion of a more interesting and investigative study. It is worth noting that the content of Anatomy and Physiology of the Human Nervous System is considered complex for students, with regard to the relationship between structure and functioning, and that the search for resources that promote learning is important. In addition, the questionnaires were analyzed in order to identify whether there was progress in the students' learning.