Sequential Alterations in Tissue Lipoprotein Lipase, Triglyceride Secretion Rates, and Serum Tumor Necrosis Factor Α During Escherichia Coli Bacteremic Sepsis in Relation to the Development of Hypertriglyceridemia

Lanza-Jacoby, Susan; Phetteplace, Hope; Sedkova, Natalia; Knee, Gerald

doi:10.1097/00024382-199801000-00007

Cited by 26 publications

(31 citation statements)

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“…However, a TNF-induced increase in triglyceride levels was also observed in humans, which was paralleled by an increased rather than decreased lipolysis (497). The increased LPS-and LTA-induced triglyceride levels, along with the evidence that LPS and LTA are neutralized by lipoproteins, led to the hypothesis that these metabolic changes may be protective during bacterial infection (189,293,313). To test this hypothesis, rats were treated with estradiol or 4-aminopyrolo-(3,4-D)-pyrimide to induce hypolipidemia, after which they were challenged with LPS.…”

Section: Lipid Metabolism and Infectionmentioning

confidence: 99%

Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock

2003

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Bacterial sepsis and septic shock result from the overproduction of inflammatory mediators as a consequence of the interaction of the immune system with bacteria and bacterial wall constituents in the body. Bacterial cell wall constituents such as lipopolysaccharide, peptidoglycans, and lipoteichoic acid are particularly responsible for the deleterious effects of bacteria. These constituents interact in the body with a large number of proteins and receptors, and this interaction determines the eventual inflammatory effect of the compounds. Within the circulation bacterial constituents interact with proteins such as plasma lipoproteins and lipopolysaccharide binding protein. The interaction of the bacterial constituents with receptors on the surface of mononuclear cells is mainly responsible for the induction of proinflammatory mediators by the bacterial constituents. The role of individual receptors such as the toll-like receptors and CD14 in the induction of proinflammatory cytokines and adhesion molecules is discussed in detail. In addition, the roles of a number of other receptors that bind bacterial compounds such as scavenger receptors and their modulating role in inflammation are described. Finally, the therapies for the treatment of bacterial sepsis and septic shock are discussed in relation to the action of the aforementioned receptors and proteins

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Section: Lipid Metabolism and Infectionmentioning

confidence: 99%

Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock

2003

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“…These mechanisms are analogous to the sepsis-related hypertriglyceridemia. (40) Fatty liver, a well known clinical manifestation of sepsis, (40) was also documented in the hypertriglyceridemia of hypernatremia. (38) In both, the fatty liver is a result of disordered fat metabolism and not the cause.…”

Section: Resultsmentioning

confidence: 99%

“…Chronic hypernatremia is a hypernatremia of more than 2 days. (40) It is generally due excessive water loss, as in diabetes insipidus, or inadequate water intake, as in essential hypernatremia.…”

Section: Introductionmentioning

confidence: 99%

Hypertriglyceridemia in Infants and Children with Hypernatremia

Ahmed

Lutfi

2015

IJHS

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“…One of the major and early responses of host metabolism to infection is an increase in circulating triglyceride concentration. Hypertriglyceridemia in infection is due to both an increase in hepatic secretion of very low-density lipoprotein (25) and alterations in the rate of clearance of triglyceride, which is brought about by a cytokine-mediated reduction in LPL activity in nearly all tissues (23). Cytokines, in particular TNF, interferon, leukemia inhibitory factor, and interleukin (IL)-1, IL-6, and IL-11, are believed to be involved in the suppression of LPL that occurs in sepsis and endotoxemia (9).…”

Section: Discussionmentioning

confidence: 99%

Effect of scopoletin on lipoprotein lipase activity in 3T3-L1 adipocytes

Yang

Koo²,

Yoon³

et al. 2007

Int J Mol Med

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Abstract. Hypertriglyceridemia is an independent risk factor of cardiovascular diseases. It is caused by the imbalance between hepatic triglyceride production and peripheral removal. Lipoprotein lipase (LPL) plays a central role in the removal of plasma triglyceride. During the screening of possible anti-dyslipidemic drugs, we observed that scopoletin (6-methoxy-7-hydroxycoumarin) significantly increased LPL activity in adipocytes. Scopoletin increased LPL activity in culture medium of 3T3-L1 adipocytes in dose-and timedependent manners. It did not release LPL from the adipocyte membrane and, instead, increased the LPL mRNA level, suggesting transcriptional control. Scopoletin also partially reversed tumor necrosis factor-α-induced suppression of LPL activity. These results suggest the possible action of scopoletin as a facilitator of plasma triglyceride clearance.

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Sequential Alterations in Tissue Lipoprotein Lipase, Triglyceride Secretion Rates, and Serum Tumor Necrosis Factor Α During Escherichia Coli Bacteremic Sepsis in Relation to the Development of Hypertriglyceridemia

Cited by 26 publications

References 0 publications

Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock

Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock

Hypertriglyceridemia in Infants and Children with Hypernatremia

Effect of scopoletin on lipoprotein lipase activity in 3T3-L1 adipocytes

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