Serological, colostral and milk responses of cows vaccinated with a single dose of a combined vaccine against rotavirus, coronavirus and Escherichia coli F5 (K99)

Abstract

Twenty-five Ayrshire/Friesian cows were vaccinated once with a new combined vaccine against rotavirus, coronavirus and Escherichia coli F5 (K99) or given a saline placebo 31 days before the first expected calving date. Blood samples were taken from the cows at intervals from vaccination until seven days after calving and from their calves up to 28 days after birth, and colostrum and milk samples were collected from the cows at intervals for 28 days after calving. There was a significant increase in the mean specific antibody titre against all three antigens in the serum of the vaccinated animals (even in the presence of pre-existing antibody) which was accompanied by increased levels of protective antibodies to rotavirus, coronavirus and E coli F5 (K99) in their colostrum and milk for at least 28 days.

Impact of rotavirus vaccine on rotavirus genotypes and caliciviruses circulating in French cattle

“…Specific amplification of genotypes G5, G6, G8, G10 and G11 and genotypes P [1], P[5]-P [7] and P [11] was performed. Of note, genotypes G5, G8, G11, P [1], P [6] and P [7] were not detected. G6P [5] strains did not reveal any major differences between strains from vaccinated and non-vaccinated herds ( Figs.…”

“…This gives key information for the development of appropriate vaccines for cattle. The most effective rotavirus vaccination strategy in cattle consists of promoting increased and prolonged anti-rotavirus protective antibody titres in mammary secretions of vaccinated pregnant cows [5,6], thus conferring passive protection to newborn calves. Indeed, it has been demonstrated that when calves are fed with colostrum from vaccinated dams from the first hours of life until they develop their own immunity, anti-rotavirus specific antibodies present in colostrum reduce the incidence of diarrhoea caused by rotavirus and viral shedding by calves infected with rotavirus.…”

Stimulation and analysis of the immune response in calves from vaccinated pregnant cows

“…Similar results were shown in another study, where a combined vaccine against rotavirus, coronavirus and E. coli was used to immunise pregnant cows. In these studies high titres of specific antibodies were measured in the colostrum and milk of dams to three components of the applied vaccine (Crouch et al, 2001). Makoschey et al (2012) have shown the effect of colostral antibodies from cow's vaccinated pre-partum with Bovilis ® Bovipast RSP on the passive immunity of their offspring.…”

Chapter 8 Control of intestinal diseases by dietary supplementation with antibodies

“…However, the most important protective role is played by specific antibodies against antigens present in the neonate's environment (Riedel-Caspari, 1993;Korhonen et al, 2000b;Le Rousic et al, 2000;Crouch et al, 2001;Pisarska et al, 2002). Maternal antibodies, obtained from the colostrum and milk, protect the neonate against infections until its own efficient specific immune protection is developed (figs.…”