Serum and Liver Cholesterol, Total Lipids and Lipid Phosphorus Levels of Rats under Various Dietary Regimens

Wilcox, Ethelwyn B.; Galloway, Leora S.

doi:10.1093/ajcn/9.2.236

Cited by 15 publications

(4 citation statements)

References 11 publications

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“…Several studies indicate that the ingestion of M. sativa reduces cholesterol absorption and atherosclerotic plaque formation in animals (Wilcox & Galloway, 1961;Malinow et al, 1977aMalinow et al, , 1981aCohen et al, 1990). M. sativa top (stem and leaves) saponins have been reported to decrease plasma cholesterol concentrations without changing high-density lipoprotein cholesterol concentrations, decrease intestinal absorption of cholesterol, increase excretion of neutral steroids and bile acids, prevent atherosclerosis and induce the regression of atherosclerosis (Malinow et al, 1982a).…”

Section: Pharmacological/clinical Reportsmentioning

confidence: 99%

Phytochemical and pharmacological potential ofMedicago sativa: A review

Bora¹,

Sharma²

2010

Pharmaceutical Biology

143

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Section: Pharmacological/clinical Reportsmentioning

confidence: 99%

Phytochemical and pharmacological potential ofMedicago sativa: A review

Bora¹,

Sharma²

2010

Pharmaceutical Biology

143

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“…In several studies, addition of alfalfa saponins to the rations of chickens, rats, and quails inhibited their growth [1‐4]; this inhibition was partially or completely reversed by incorporation of cholesterol into the diet [1, 4‐6]. Other toxic effects were not noted in these two‐ to three‐week experiments.…”

Section: Introductionmentioning

confidence: 92%

Lack of Toxicity of Alfalfa Saponins in Cynomolgus Macaques

Dc³

et al. 1982

J Med Primatol

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An extract from alfalfa meal, operationally defined as alfalfa saponins, was incorporated into the food of female cynomolgus macaques (Macaca fascicularis). Monkeys received diets with and without added cholesterol. No signs of toxicity were detected from records of survival and body weight, from multiple hematologic and serum parameters, or from macroscopic and microscopic examination of various organs and tissues. Since alfalfa saponins lower plasma cholesterol levels and decrease atherogenesis, they may be useful for treating patients with atherosclerosis associated with a disturbed cholesterol metabolism.

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“…Menurut Wilcox et al dan Malinow et al bahwa saponin berperan menghambat penyerapan kolesterol di usus. 13,14 Konsekuensi penghambatan penyerapan kolesterol adalah kolesterol dikeluarkan dari tubuh bersama feses yang merupakan lintasan utama untuk mengeluarkan kolesterol.…”

Section: Pembahasanunclassified

Efek ekstrak daun sirsak (Annona muricata Linn) terhadap profil lipid tikus putih jantan (Rattus Norvegicus)

Wurdianing

Nugraheni

Rahfiludin

2014

JGI

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Background: Lipid profile effects is a risk factor for Coronary Heart Disease. Soursop leaves (Annona muricata L) isa traditional medicine plant containing metabolic compounds that contribute to the improvement of the lipid profile.Objective: To determine the effects of soursop leaves extract on lipid profile (total cholesterol, LDL cholesterol, HDLcholesterol and triglyceride).Methods: An experimental study using randomized pre-posttest with control group design. Sample consisted of 28 maleWistar rats, were divided into four groups. The control group (K) was only given High Fat High Cholesterol (HFHC)diet and treatment groups (P1, P2, P3) were given a HFHC diet plus Annona muricata L extract with doses of 100, 200and 300 mg/kgBB per day for 28 days respectively. Data were analyzed by Wilcoxon test, Kruskal-Wallis and MannWhitney.Results: The mean total cholesterol level significantly decreased in the treatment group P1 (p = 0.028) from 60.7 mg/dl(47.6-75.3) to 45.5 mg/dl (38.4-62.4). Mean HDL cholesterol level significantly increased in the treatment group P2(p=0.043) from 26.0 mg/dl (19.7-35.3) to 27.9 mg/dl (18.8-38.0). The mean levels of LDL cholesterol and triglyceridedecreased but not significantly.Conclusion: The administration of Annona muricata L extract can decrease total cholesterol and increase HDLcholesterol significantly.

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Serum and Liver Cholesterol, Total Lipids and Lipid Phosphorus Levels of Rats under Various Dietary Regimens

Cited by 15 publications

References 11 publications

Phytochemical and pharmacological potential ofMedicago sativa: A review

Phytochemical and pharmacological potential ofMedicago sativa: A review

Lack of Toxicity of Alfalfa Saponins in Cynomolgus Macaques

Efek ekstrak daun sirsak (Annona muricata Linn) terhadap profil lipid tikus putih jantan (Rattus Norvegicus)

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