Serum copper and zinc concentrations in serum from patients with cancer and cardiovascular disease

Present study reports changes in serum copper levels (SCL) in various neoplastic diseases undergoing radiotherapy. We estimated SCLs in 140 individuals comprising of 90 previously untreated patients with various malignancies and 50 healthy controls. Patients received radiation in doses of 40-70 Gy in 4-7 weeks. SCLs were again estimated in patients following irradiation, the mean SCL was significantly higher (P<0.001) in cancer patients as compared to healthy controls. It declined significantly (P<0.001) following irradiation. However, it remained significantly higher as compared to healthy controls (P<0.01). Highest fall in SCL was seen in complete clinical responders and least in non-responders to radiation treatment. Serial estimation of SCLs may be useful in the treatment monitoring of the neoplasms undergoing radiation treatment.

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“…(5) did not find significant elevation in mean SCLs in cancer patients as compared to controls. Jacobs et.al.…”

Section: Author For Correspondencecontrasting

confidence: 53%

Changes in serum copper levels in patients with malignant diseases undergoing radiotherapy

Mali

Siddiqui

Garg

et al. 1998

Indian J Clin Biochem

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“…The mechanism by which Zinc interferes with gastric carcinogenesis has not been clarified (Martin-Lagos et al, 1997;Lamson and Brignall, 2001;Abnet et al, 2005;Zarghami et al, 2005;Khorasani et al, 2008;Sadat et al, 2008). Zinc may bring contribute to some cause to the host defense mechanism by maintaining the structure and function of the membrane barrier (Newberne, 1987;Finamore et al, 2008), that is especially important in the gastro-intestine tract, which is continuously exposed to plenty of pathogens and noxious agents.…”

Section: Discussionmentioning

confidence: 99%

Serum Zinc Status and Helicobacter Pylori Infection in Gastric Disease Patients

Zhang¹,

Wu²,

Niu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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The role of Helicobacter pylori status and serum zinc value in gastric disease patients and healthy controls were investigated. Cases used in this work were 45 gastric cancer patients, 44 with peptic ulcers, 52 suffering gastritis and 64 healthy controls, all diagnosed histologically with the controls undergoing medical checkups. Helicobacter pylori status and serum levels of Zn were determined by 13C-urea breath test and flame atomic absorption spectrophotometer, respectively. Our study showed that Helicobacter pylori infection has no change in gastritis, peptic ulcer and gastric cancer group, on the contrast, serum levels of Zn were significantly reduced in gastritis, peptic ulcer and gastric cancer group, compared with healthy controls, and the higher the Zn levels are, the more increased risk of gastric cancer. Helicobacter pylori infection is a cause of gastritis, peptic ulcers and even gastric cancer, while serum zinc level is an indicator of protection of gastric membranes against damage.

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“…(n=19), (3) non-human studies (n=69), and (4) articles not providing Zn levels for both subjects with MI and healthy controls (n=3). Overall, thirteen eligible articles with 2886 subjects from 41 case-control studies were considered in the analysis [11][12][13][14][15][16][17][18][19][20][21][22][23]. A flow diagram of the study selection process is presented in Fig 1. …”

Section: Literature Searchmentioning

confidence: 99%

“…Some clinical studies found that there was a significant relationship between Zn deficiency and MI risk [11][12][13][14]. However, some studies suggest that there is no correlation between Zn levels and MI risk [15][16][17]. Although Zn deficiency is plausibly linked to an increase risk of MI, the inconsistency among the findings of previous studies precludes definitive recommendations at present.…”

Section: Introductionmentioning

confidence: 99%

Deficient Zinc Levels and Myocardial Infarction

Liu¹,

Cai

Zhou³

2015

Biol Trace Elem Res

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The purpose of this study is to clarify the association between Zn levels and myocardial infarction (MI) using a meta-analysis approach. We searched articles in the PubMed, OVID, and ScienceDirect published as of November 2014. Thirteen eligible articles with 2886 subjects from 41 case-control studies were identified. Overall, pooled analysis indicated that subjects with MI had lower Zn levels than healthy controls (standardized mean difference (SMD) = -1.848, 95 % confidence interval (CI) = [-2.365, -1.331]). Further subgroup analysis found that subjects with MI had lower Zn levels than healthy controls in serum (SMD = -1.764, 95 % CI = [-2.417, -1.112]) and hair (SMD = -3.326, 95 % CI = [-4.616, -2.036]), but not in toenail (SMD = -0.396, 95 % CI = [-1.114, 0.322]). The subgroup analysis stratified by type of Zn measurement found a similar pattern in inductively coupled plasma-atomic absorption spectrometry (ICP-AAS) (SMD = -2.442, 95 % CI = [-3.092, -1.753]), but not in neutron activation analysis (NAA) (SMD = -0.449, 95 % CI = [-1.127, 0.230]). Lower Zn levels in MI patients were found both in male (SMD = -3.350, 95 % CI = [-4.531, -2.169]) and female (SMD = -2.681, 95 % CI = [-3.440, -1.922]). And the difference of Zn levels according to MI in Asia (SMD = -2.555, 95 % CI = [-3.267, -1.844]) was greater to that among the population in Europe (SMD = -0.745, 95 % CI = [-1.386, -0.104]), but no difference was found in Oceania (SMD = -0.255, 95 % CI = [-0.600, 0.089]). In conclusion, this meta-analysis indicates that there is a significant association between Zn deficiency and MI. We suggest that a community-based, long-term observation in a cohort design should be performed to obtain better understanding of causal relationships between Zn and MI, through measuring hair Zn at baseline to investigate whether the highest zinc category versus lowest was associated with MI risk.

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Serum copper and zinc concentrations in serum from patients with cancer and cardiovascular disease

Cited by 48 publications

References 28 publications

Changes in serum copper levels in patients with malignant diseases undergoing radiotherapy

Changes in serum copper levels in patients with malignant diseases undergoing radiotherapy

Serum Zinc Status and Helicobacter Pylori Infection in Gastric Disease Patients

Deficient Zinc Levels and Myocardial Infarction

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