Serum electrolytes and lipid profiles in non-insulin dependent diabetes mellitus patients

Abstract

Background: Diabetes mellitus and hyperlipidemia are the most common metabolic disorder affecting the people all over the world. Hyperglycemia is considered a primary cause of diabetic vascular complications and is associated with impaired electrolytes in some of the metabolic dysfunctions is not clear. Aim: The purpose of this study was conducted to investigate the relationship among diabetes mellitus, lipid profiles and electrolytes (Na+, K+ and Cl-). Methods: In the sera of 85 non insulin-dependent diabetes mellitus NIDDM, 45 with hyperlipidemia, 40 without hyperlipidemia, 50 samples of hyperlipidemia without NIDDM, and 50 non diabetic healthy control subjects. The mean age of the diabetic patients was similar to that of control. The mean duration of the disease was (10.2±5.9) years (2-23) years. From the results, it was discovered that there was a significant decrease in Na+ and Cl- in patients with NIDDM without high level of lipid profile (group I), but our results show that the concentration of K+ not changed significantly. The plasma levels of Na+ and Cl- ions were show significant change in patient with hyperlipidemia without NIDDM (group II), while plasma K+ not changed significantly in this group as compared with control. The mean value of Na+ and Cl- show high significant change in NIDDM patients with high level of lipids profile (group III),were plasma K+ not changed significantly as compared with control group. Conclusion: These finding may explain the role of impaired electrolytes status in NIDDM and hyperlipidemia subjects. DOI: http://dx.doi.org/10.3126/ajms.v6i3.11088Asian Journal of Medical Sciences Vol.6(3) 2015 38-41

Dyselectrolytemia in hyperglycaemic crisis patients with uncontrolled non-insulin dependent diabetes mellitus

“…In present study we have found significantly increased levels of Sodium in Case group (Table 1). Similar findings are reported by Kavelaars et al and Danowsky TS et al 10,11 However, contradictory findings, i.e., hyponatraemia in diabetes mellitus, are reported by Namama Talabani, McNair P et al and George Liamis et al 4,12,13 Poorly controlled DM may lead to the development of hypernatremia. 5 Depending upon the balance between the hyperglycemiainduced water movement out of the cells lowering sodium, and the glucosuria-induced osmotic diuresis increasing sodium, serum sodium concentration is variable in patients with uncontrolled DM.…”

“…3 Diabetes mellitus (DM) is amongst those diseases which show frequent disturbances of electrolytes and acid -base relations, especially in patients with deranged renal function and other end-organ injury, mal-absorption syndromes, acid-base imbalances and multiple drug regimens and medications for diabetes management. [4][5][6][7] The knowledge and insight of the disease process and its management, would create the way for 'pathophysiologydirected therapy', leading to prevention of the several adverse effects associated with acid-base and electrolyte disorders and their management.…”

Electrolyte disturbances in diabetic patients in Cotonou, Benin

“…The study of Wang in China revealed significantly higher proportion of hyperkalemia and hypokalemia among the diabetics in contrary to our results which showed no difference between the proportions of hypokalemia in comparison to the control population. 16 Talabani found no differences in the mean level of potassium, 26 whereas geographically closer to our country Ugwuja in Nigeria and Oyewole in SierraLeone reported lower mean level of potassium in diabetics than in control subjects. 14,27 In our study, the rate of hyponatremia among diabetic patients was similarly high as that of hyperkalemia (45.33% versus 48%).…”

“…14,24,26,27 Among the diabetic population, the observed alterations in the electrolytes levels were not correlated with the plasma glucose level. However the highest kalemia value was found in the group of glycaemia >2g/L (group III), the group with glycaemia between 1.2-2g/L (group II) exhibited a lower mean value of potassium than the group of glycaemia <1.2 g/L (group I).…”

“…7,8 Several studies revealed lower sodium mean level in diabetic population. [23][24][25][26][27] Hyponatremia occurs frequently in diabetes but hypernatremia can also be observed in the development of the disease. Shahid reported increased sodium mean level among the diabetics group but his findings of potassium level were similar to our results and others investigations.…”