Serum lipids and oxidized low density lipoprotein levels in sickle cell disease: Assessment and pathobiological significance

Diatta, Ampa Dogui; Ciss, Fatou; Guye, Tall Fatou; Diallo, Fatoumata; Tour, Fall Awa Oumar; Sarr, Gaston Ndn; Lopez, Sall Philomne; Sall, Niama Diop; Tour, Mssa

doi:10.5897/ajbr12.095

Cited by 6 publications

(5 citation statements)

References 30 publications

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“…These results are in keeping with values in adult African -American SCA patients reported in 2003 in which there was a higher than normal reference in plasma triglyceride but lower values of total cholesterol, high density lipoprotein (HDL) and low density lipoprotein (LDL) [39]. The findings are also in keeping with data of Indians in 2016 [40] and Senegalese in 2014 [41]. By implication, hypocholesterolemia, low LDL and HDL and higher values of TG and VLDL reported severally in SCA patients may not be related to age, race, socio-economic status or diet but may be genetic and related to the pathophysiology of the disease.…”

Section: Discussionsupporting

confidence: 90%

On artherogenic index of plasma in sickle cell anaemia patients

Akinbami¹,

Uche²,

Suleiman³

et al. 2019

Pan Afr Med J

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Introduction Sickle cell anaemia (SCA) is an inherited abnormality of haemoglobin associated with reduced life expectancy. Patients' complications include dyslipideamia. This study was aimed at determining the artherogenic index of plasma (AIP) in sickle cell anaemia patients and compares the value to HbAA controls value. A high AIP is strongly predictive of elevated cardiovascular risk. Methods A comparative study was conducted among SCA patients attending the haematology clinic, Lagos State University Teaching Hospital (LASUTH) and HbAA Phenotype controls. A total of 304 participants were recruited consisting of equal numbers of SCA and HbAA controls. Single lipid profiles were done; logarithms of triglycerides/high density lipoprotein were calculated to obtain AIP and lipid profile ratios established for all participants. Results There were lower mean values of Total Cholesterol (TC), High Density Lipoprotein(HDL) and Low Density Lipoprotein (LDL) amongst SCD participants than controls and higher mean values of triglycerides (TG) and Very Low Density Lipoprotein (VLDL) in SCD p < 0.05. The AIP in SCD ranges from -0.62 to 1.32 while that of controls ranges from -0.56 to 0.61.The mean AIP were 0.14 ± 0.29 and -0.009 ± 0.26 in SCD and controls respectively. P value = 0.002. Conclusion AIP value is higher in sickle cell anaemia than controls, the former have lower mean values of TC, HDL and LDL and higher mean values of TG and VLDL.

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Section: Discussionsupporting

confidence: 90%

On artherogenic index of plasma in sickle cell anaemia patients

Akinbami¹,

Uche²,

Suleiman³

et al. 2019

Pan Afr Med J

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“…COA Carboxylase and reduced the activity of cholesterol Acyltransferase and lecithin and inhibiting the activity of lipoprotein lipase and liver lipase activity that led to increased synthesis of vL DLc and decreased the concentration of HDL-C [21]. In this study found a strong significant effect between ox-LDL and total cholesterol ratio and known that HDL levels are associated with age in women, HDLcholesterol levels increase progressively to the fifth decade and then decrease with menopause, the mechanism may influence the data on HDL-C concentration [22]. One of the more prominent markers of oxidative stress in DM is ox-LDL ; increased production of free oxygen radicals, higher ox-LDL along with stimulation of ox-LDL uptake by macrophages and the ensuing promotion of early atherosclerotic changes might be contributed by insulin resistance (IR);hyperglycemia is associated by increased inflammatory burden and increased lipid peroxidation ,all leading to inhanced macrophage foam cell formation , low density lipoprotein (LDL) oxidation by macrophages was increased due to the activation of several pro-oxidant systems as well as the depletion of antioxidants [23] ox-LDL and oxidation ratio of LDL (ox-LDL/TC, ox-LDL/HDL-C, and ox-LDL/LDL-C) are closely related with CHD and they are better biomarkers for discrimination between patients with coronary heart disease and healthy [24].…”

Section: Resultssupporting

confidence: 49%

Oxidized LDL and Risk of Coronary Heart Disease

Baker¹

2023

Tikrit J. Pure Sci.

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Oxidized LDL cholesterol (ox-LDL) is considered to be a key factor of initiating and accelerating coronary heart disease CHD and diabetes Mellitus DM , is associated with several mechanisms one of them Oxidative stress. The aim of this study was to find the association between ox- LDL ,HDL-C , TG , LDL-C and arylesterase , with CHD risk in different age groups in males and females , the difference in these risk factors can explain the sex difference and how much the changes in the risk factors levels in CHD and CHD with DM patients between age groups. Methods: determination biochemical parameters of serum blood of ox-LDL , TG , TC , HDL-c , LDL-c , S. Glucose and arylesterase activity were measured in cases male and females were carried CHD and CHD with DM .The cases divided in different the age groups (40-49) , (50-59) and (60-69) years and compered the result with control groups . Results: mean Value of ox-LDL and oxidation ratio of LDL show significantly higher at (p<0.05) in CHD and (p<0.001) in CHD with DM patient for females in the age group (40-49) years but in the males show the results significant decrease and different significant in others groups ,beside to effect Sex and age some the studied biochemistry parameters levels and signification decrease in HDL-C and arylesterase levels as antioxidant enzymes in females and male patient selected compared with control groups.

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“…Prior in vitro studies have indicated that lipoproteins contribute significantly to the consumption of plasma heme and lipid oxidation (30). Chronic hemolysis and episodic increases in hemolytic rate occur in SCD in the setting of depleted scavenger proteins (Hp and Hpx), which likely renders lipoproteins more prone to oxidative modification and contributes to a higher ratio of oxidized to reduced lipids in the plasma of patients with SCD (1,4).…”

Section: Discussionmentioning

confidence: 99%

Depletion of haptoglobin and hemopexin promote hemoglobin-mediated lipoprotein oxidation in sickle cell disease

Yalamanoglu

Deuel

Hunt

et al. 2018

American Journal of Physiology-Lung Cellular and Molecular Phys

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Intravascular sickling and lysis of red blood cells (RBC), a hallmark feature of sickle cell disease (SCD), releases hemoglobin into the circulation. Increased cell-free Hb has been linked to vasculopathy and in vitro lipid oxidation. Scavenger plasma proteins haptoglobin (Hp) and hemopexin (Hpx) can attenuate cell-free Hb and total plasma heme lipid-oxidative capacity but are depleted in SCD. Here, we isolated lipids from BERK-SS mice, Guinea pigs (GP) infused with heme-albumin and SCD patients undergoing regular exchange transfusion therapy and evaluated the level of lipid oxidation. Malondialdehyde (MDA) formation, an end product of lipid peroxidation, was increased in BERK-SS mice, purified lipid fractions of the heme-albumin infused GP and SCD patients compared to controls. In humans the extent of lipid oxidation was associated with the absence of Hp as well as decreased Hpx in plasma samples. Post-mortem pulmonary tissue obtained from SCD patients demonstrated oxidized LDL deposition in the pulmonary artery. The relationship between no Hp and low Hpx levels with greater LDL and HDL oxidation demonstrates the loss of protection against cell-free Hb and total plasma heme mediated lipid oxidation and tissue injury in SCD. Strategies to protect against plasma lipid oxidation by cell-free Hb and total plasma heme (e.g. therapeutic Hp and Hpx replacement) may diminish the deleterious effects of cell-free Hb and total plasma heme towards the vascular system in SCD.

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Serum lipids and oxidized low density lipoprotein levels in sickle cell disease: Assessment and pathobiological significance

Cited by 6 publications

References 30 publications

On artherogenic index of plasma in sickle cell anaemia patients

On artherogenic index of plasma in sickle cell anaemia patients

Oxidized LDL and Risk of Coronary Heart Disease

Depletion of haptoglobin and hemopexin promote hemoglobin-mediated lipoprotein oxidation in sickle cell disease

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