Serum Lipids, Postheparin Plasma Lipase Activities and Glucose Tolerance in Patients With Prolactinoma

Pelkonen, Risto; Nikkilä, Esko A.; Grahne, Bertel

doi:10.1111/j.1365-2265.1982.tb00731.x

Cited by 41 publications

(33 citation statements)

References 32 publications

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“…In agreement with the results of other reported studies [1][2][3], fasting plasma glucose concentrations were not increased in hyperprolactinemic women. Premeal and postprandial glucose values were not significantly higher in these patients than in normal women.…”

Section: Commentsupporting

confidence: 83%

“…Premeal and postprandial glucose values were not significantly higher in these patients than in normal women. The findings differ from previous reports describing a reduced glucose tolerance in hyperprolactinemic patients [1][2][3]. How ever, Katz et al [4] found a normal intravenous glucose tolerance in patients with prolactinoma.…”

Section: Commentcontrasting

confidence: 56%

“…Various at tempts have been made to determine the 'diabetogenic effect' of PRL by analyzing plasma glucose and insulin relationships in response to acute glucose loading [1][2][3]. In one study, glucose and insulin responses to the physi ologic stimulus of mixed meals were evaluated in hyper prolactinemic women [4].…”

Section: Introductionmentioning

confidence: 99%

“…Chronic hyperprolactinemia is associated with re duced glucose tolerance [1][2][3], and therefore prolactin (PRL) may be a diabetogenic hormone. Various at tempts have been made to determine the 'diabetogenic effect' of PRL by analyzing plasma glucose and insulin relationships in response to acute glucose loading [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

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Levels of Glucose and Insulin during Twenty-Four Hours in Hyperprolactinemic Women with Pituitary Microadenoma

Seki¹,

Nagata²

1991

Gynecol Obstet Invest

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Excursions of plasma glucose and insulin throughout the 24-hour metabolic clock were evaluated in hyperprolactinemic women with pituitary microadenoma. The glucose response to food intake and 24-hour excursion of plasma glucose were not altered in hyperprolactinemic women compared to normal women. Premeal and 24-hour insulin levels were significantly increased in hyperprolactinemic women, though fasting insulin levels were not. Postprandial insulin increments appeared to be more sustained in these patients compared to normal women, though the difference was not statistically significant. And therefore the increased 24-hour concentration of insulin in hyperprolactinemic women appears to be due to the sustained insulin response to meals and increased premeal insulin levels. A slight resistance to insulin was observed in hyperprolactinemic women. That the 24-hour excursion of plasma glucose is not altered in hyperprolactinemic women in the face of decreased sensitivity to insulin may be accounted for by the increased insulin secretion.

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Section: Commentsupporting

confidence: 83%

Section: Commentcontrasting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Levels of Glucose and Insulin during Twenty-Four Hours in Hyperprolactinemic Women with Pituitary Microadenoma

Seki¹,

Nagata²

1991

Gynecol Obstet Invest

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“…In rats and humans, PRL increases β-cell proliferation, insulin gene transcription and glucose-dependent insulin secretion [73,74,75,76]. In men and women with chronic hyperprolactinemia, post-prandial hyperinsulinemia and exaggerated insulin secretory response to glucose have been demonstrated [77,78,79]. Interestingly, pancreatic β cells also express dopamine receptors and treatment with the selective D 2 R agonist quinpirole causes the inhibition of glucose-stimulated insulin secretion [80].…”

Section: Discussionmentioning

confidence: 99%

Effect of Cabergoline on Metabolism in Prolactinomas

Auriemma¹,

Granieri²,

Galdiero³

et al. 2013

Neuroendocrinology

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Introduction: Hyperprolactinemia has been implicated in the pathogenesis of obesity and glucose intolerance and is reportedly associated with an impaired metabolic profile. The current study aimed at investigating the effects of 12- and 60-month treatment with cabergoline (CAB) on metabolic syndrome (MetS) in patients with prolactinomas. Patients and Methods: 61 patients with prolactinomas (13 men, 48 women, 41 with microadenoma, 20 with macroadenoma), aged 34.4 ± 10.3 years, entered the study. In all patients, prolactin (PRL) and metabolic parameters were assessed at diagnosis and after 12 and 60 months of continuous CAB treatment. MetS was diagnosed according to NCEP-ATP III criteria. Results: Compared to baseline, CAB induced a significant decrease in PRL with complete normalization in 93% of patients after the 60-month treatment. At baseline, MetS prevalence was significantly higher in patients with PRL above (34.5%) than in those with PRL lower (12.5%) than the median (129 μg/l, p = 0.03). MetS prevalence significantly decreased after 12 (11.5%, p = 0.039) and 60 (5.0%, p = 0.001) months compared to baseline (28.0%). At both evaluations the lipid profile significantly improved compared to baseline. Fasting insulin and homeostatic model assessment of insulin resistance significantly decreased after 1 year of CAB (p = 0.012 and p = 0.002, respectively) and further improved after 60 months (p = 0.000). The visceral adiposity index significantly decreased after the 60-month treatment (p = 0.000) compared to baseline. At the 5-year evaluation CAB dose was the best predictor of percent decrease in fasting insulin (t = 2.35, p = 0.022). Conclusions: CAB significantly reduces MetS prevalence and improves the adipose tissue dysfunction index. The improvement in PRL, insulin sensitivity and other metabolic parameters might reflect the direct effect of CAB.

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Chronic hyperprolactinemia and plasma lipids in women

1987

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Plasma total cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C) were studied in 15 hyperprolactinemic women who had a prolactin (PRL) adenoma, in comparison to 15 age-matched control women. In the hyperprolactinemic group, plasma lipids were also correlated to age, excess body weight (EBW), plasma PRL, and estradiol-17 beta (E2). Plasma TC, TG, and LDL-C were similar in both hyperprolactinemic and control women, while plasma HDL-C was significantly lower (P less than 0.01) in the hyperprolactinemic group. The correlation study showed a significant negative correlation between HDL-C and EBW (r = -0.64; P less than 0.02) and a slightly significant positive correlation between TG and PRL (r = 0.54; P less than 0.05). The direct effect of PRL on plasma lipids is difficult to establish since many factors influencing lipid metabolism are altered during hyperprolactinemia.

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Serum Lipids, Postheparin Plasma Lipase Activities and Glucose Tolerance in Patients With Prolactinoma

Abstract: prolactinoma is associated with metabolic abnormalities characterized by hyperlipidaemia, low plasma LPL activity and insulin resistance.

Cited by 41 publications

References 32 publications

Levels of Glucose and Insulin during Twenty-Four Hours in Hyperprolactinemic Women with Pituitary Microadenoma

Levels of Glucose and Insulin during Twenty-Four Hours in Hyperprolactinemic Women with Pituitary Microadenoma

Effect of Cabergoline on Metabolism in Prolactinomas

Chronic hyperprolactinemia and plasma lipids in women

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