Serum Magnesium in Insulin-Dependent Diabetics and Healthy Subjects in Relation to Insulin Secretion and Glycemia during Glucose-Glucagon Test^*

Abstract

Certain RIS existed in 11 insulin-dependent diabetics, 12 were without any RIS (uncertain RIS in 10 patients). Glucose tolerance and daily glycemia differed significantly among the two groups. However, all diabetics were far from euglycemia, (3.3-9.3 mmol/l): Fasting plasma glucose 12.0 +/- 0.9 (certain RIS), 15.0 +/- 0.8 (no RIS), 13.9 +/- 1.8 (uncertain RIS). Serum magnesium was significantly lower in all diabetics, both before and during the test. There was no change during the OGTT-glucagon-test and no difference among the three groups of insulin-dependent diabetics. So, we conclude that a small RIS in our longterm insulin-dependent diabetics has no influence on the behaviour of serum magnesium. But, magnesium depletion can influence coronary blood flow, blood clotting, and atherogenesis. Therefore, it should be necessary to pay more attention to the hypomagnesemia in insulin-dependent diabetics.

Association between magnesium concentration and HbA1c in children and adolescents with type 1 diabetes mellitus (儿童与青少年1型糖尿病患者的镁浓度与HbA1c之间的关系)

“…It is well established that circulating magnesium levels tend to decrease in adults with either T1DM or T2DM, especially in poorly controlled patients with a long duration of diabetes, 20-30 independent of residual insulin secretory status. 31 Moreover, previous studies have reported significantly lower total serum or plasma magnesium levels in children with known or newly diagnosed insulindependent diabetes mellitus (IDDM) compared with their healthy peers, [8][9][10][11] although conflicting results have been published as well. [32][33][34][35] Furthermore, children with IDDM retained a significantly greater percentage of magnesium than controls during a magnesium tolerance test, thus confirming lower magnesium levels.…”

The Mammalian Stress Mechanism (MSM) Explains Radial Artery Spasm (RAS)

“…Drugs and chemicals that elevate Ca+ levels exaggerate thrombin generation, and vice-versa. Mg+ competitively inhibits Ca+ and mitigates thrombin generation [27,64,[78][79][80][81][82][83][84][85][86][87][88][89][90][91][92][93][94] . Magnesium sulfate is used to treat eclampsia, a treatment readily explained by its thrombin inhibition.…”

A Stress Repair Mechanism That Maintains Vertebrate Structure During Stress

“…Thrombin activity requires Ca + , and parathyroid glands regulate extracellular Ca + to optimize its activity [26,[66][67][68][69][70][71][72][73][74][75][76][77][78][79]. Mg + competitively inhibits Ca + and mitigates thrombin activity [66,75,[80][81][82][83][84][85][86][87][88][89][90][91][92][93][94][95][96].…”