Serum Noradrenaline Response to Standing Up in Patients with Parkinson’s Disease&lt;sup&gt;1&lt;/sup&gt;

Turkka, Jukka; Juujärvi, K.; Lapinlampi, Tuomo; Myllylä, V.V.

doi:10.1159/000116034

Cited by 30 publications

(25 citation statements)

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“…Stud ies prior to 1989 which include figures for prevalence of autonomic symptomatology [2,3] either offer no infor mation on sexual dysfunction or involve only a small number of patients [2], The only study that mentions sex ual impotence as a symptom specifically investigated is the report by Aminoff and Wilcox [4] who reported none in 4 of his male PD patients. Lipe et al [8] discussed sex ual dysfunction in PD men and age-matched men af fected with arthritis.…”

Section: Discussionmentioning

confidence: 99%

“…Autonomic dysfunction in association with Parkin son's disease (PD) has been described before in a number of reports including James Parkinson's original mono graph [1], There are very' few studies which address the prevalence of diverse autonomic symptomatology in PD [2,3], and they do not include data for the prevalence of certain symptoms such as erectile dysfunction (ED) and other sexual dysfunctions, dysphagia or heartburn. These reports tend to characterize these symptoms collectively as disturbances of micturition or symptoms of bowel dys function.…”

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confidence: 99%

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Autonomic Dysfunction in Men with Parkinson’s Disease

1992

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Forty-eight men with Parkinson’s disease (PD) were interviewed utilizing a questionnaire which evaluated autonomic function. The study population included PD patients (mean age: 65.8 years, mean duration of PD: 8 years) and 32 elderly healthy nonparkinsonian males (mean age: 70.4 years). We found a significantly higher prevalence of the following symptoms of autonomic dysfunction in the parkinsonian patients: erectile dysfunction (60.4 vs. 37.5%), sensation of incomplete bladder emptying (41.6 vs. 15.6%), urgency (45.8 vs. 3.125%), constipation (43.9 vs. 6.25%), dysphagia (22.9 vs. 6.25%) and orthostatic dizziness (21.95 vs. 0%). Eighty-nine percent of parkinsonian patients had at least one of these autonomic symptoms, compared to 43% of control subjects (p < 0.05). This study is the first comprehensive survey of autonomic symptomatology in PD compared to elderly healthy controls and confirms that autonomic nervous system dysfunction is a pervasive problem in PD. Erectile dysfunction is a significant problem in this patient group and contributes to deterioration in the quality of life.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Autonomic Dysfunction in Men with Parkinson’s Disease

1992

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“…[13] Turkka et al measured the serum noradrenalin and found no significant difference in baseline serum noradrenaline between patients with PD and healthy individuals. [14] Mehagnoul-Schipper et al also found similar resting HR and BP between patients with PD and control group. [15] A study by Barbic et al showed that in the supine position, patients with PD showed similar cardiovascular, neural modulation as in healthy age-matched controls.…”

Section: Discussionmentioning

confidence: 79%

Autonomic cardiovascular regulation in Parkinson's disease by head-up tilt test - A cross-sectional study

Jaipurkar¹,

Mohan²,

Tomar³

2018

Natl J Physiol Pharm Pharmacol

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Background: Autonomic failure is an integral component of Parkinson's disease (PD), and orthostatic hypotension (OH) is commonly observed in advanced cases of PD. OH may be the result of underlying cardiovascular autonomic dysfunction or adverse effect of antiparkinsonian drugs. Patients may be asymptomatic during the early stage of disease but may have underlying cardiovascular dysautonomia which becomes obvious on stress. Most of the earlier studies used morphological and functional methods to evaluate cardiovascular autonomic control but were unable to evaluate during dynamic conditions. Aims and Objectives: The aim of the study was to evaluate cardiovascular autonomic disturbances in patients with PD using head-up tilt table test (HUTT). The objective of the study was to compare the spectral profile of heart rate variability (HRV) and blood pressure (BP) to orthostatic challenges using HUTT in patients with PD with healthy individuals. Materials and Methods: In this cross-sectional study, we have recorded continuous lead II ECG along with BP every 2 min in patients with PD and control group during HUTT for 10 min in supine, 45 min in 70° tilt and again 10 min in supine position which were later analyzed using Biopac software for HRV. Results: Symptoms indicating autonomic nervous system dysfunction were present in 65% (20) patients with PD. Postural dizziness was present in 20% (6) patients. After 5 min of tilt-up, increase in HR in patients with PD was lower than in controls. There was no significant change in diastolic BP (DBP) on tilting-up in patients with PD while DBP significantly increased in controls on tilting-up from73 ± 9 mm Hg to 80±11 mm Hg (P < 0.00001). The low frequency (LF) was not significantly changed in patients with PD, and it increased significantly in controls from 3.05 (2.28 to 4.70) ms 2 to 3.73 (2.69-5.03) ms

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“…Many investigators have reported that the plasma norepinephrine concentration is lower in PD patients [24]. The plasma norepinephrine concentration during standing responses is low in PD patients [18,19,24,25]. Cardiac (123)I-metaiodobenzylguanidine (123I-MIBG) is a pharmacologically inactive analogue of norepinephrine, which is similarly metabolized in noradrenergic neurons.…”

Section: Discussionmentioning

confidence: 99%

Effect of Subthalamic Nucleus Deep Brain Stimulation on the Autonomic Nervous System in Parkinson’s Disease Patients Assessed by Spectral Analyses of R-R Interval Variability and Blood Pressure Variability

Sumi

Katayama²,

Otaka³

et al. 2012

Stereotact Funct Neurosurg

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Objective: Autonomic nervous system impairment is an untoward symptom that is typically observed in advanced Parkinson’s disease (PD) patients. However, details of the effects of subthalamic nucleus deep brain stimulation (STN-DBS) on the autonomic nervous system remain unclear. Methods: Twenty-eight patients with advanced PD (12 males and 16 females) who underwent bilateral STN-DBS and 13 age-matched healthy controls were included in this study. We analyzed the dynamic cardiovascular autonomic function regulating the R-R interval and blood pressure by spectral and transfer function analyses of cardiovascular variability before and after STN-DBS. Results: Vagally mediated arterial-cardiac baroreflex function improved after STN-DBS compared to that before STN-DBS (p < 0.05). However, there were no statistically significant differences in the results of the comparison of vagally mediated arterial-cardiac baroreflex function between on-stimulation and off-stimulation. Conclusions: The vagal component in cardiac autonomic dysfunction associated with PD is expected to improve after STN-DBS. We considered that the patients improved their lifestyle; in particular, increasing the amount of exercise by STN-DBS and the best pharmachological treatment may have positive effects on parasympathetic activities.

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Serum Noradrenaline Response to Standing Up in Patients with Parkinson’s Disease<sup>1</sup>

Cited by 30 publications

References 0 publications

Autonomic Dysfunction in Men with Parkinson’s Disease

Autonomic Dysfunction in Men with Parkinson’s Disease

Autonomic cardiovascular regulation in Parkinson's disease by head-up tilt test - A cross-sectional study

Effect of Subthalamic Nucleus Deep Brain Stimulation on the Autonomic Nervous System in Parkinson’s Disease Patients Assessed by Spectral Analyses of R-R Interval Variability and Blood Pressure Variability

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