Serum Prolactin Levels and Behçet Disease

Proença, Hugo Manuel; Ferreira, Cristina; Miranda, María Adelaide; Castanheira–Dinis, A.; Monteiro-Grillo, Manuel

doi:10.1177/112067210701700322

Cited by 17 publications

(14 citation statements)

References 9 publications

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“…The relationship between BD and PRL had also been studied (5)(6)(7)(8)(9) and were found to be related to disease activity in some of the reports (5, 6), but the results are conflicting. None of these studies categorized the patients considering their sex, making it impossible to compare the difference of PRL levels between female and male patients.…”

Section: Discussionmentioning

confidence: 99%

“…There are little data on serum hormone concentrations of female patients with BD and most of these studies are about possible relationship of prolactin on BD pathogenesis or disease activity (5)(6)(7)(8)(9). Although some of these studies suggest a possible role for this immunoregulatory hormone in the disease expression and pathogenesis (5,6), no such correlation has been found in several others (7)(8)(9).…”

mentioning

confidence: 92%

“…Although some of these studies suggest a possible role for this immunoregulatory hormone in the disease expression and pathogenesis (5,6), no such correlation has been found in several others (7)(8)(9).…”

mentioning

confidence: 99%

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Assesment of ovarian stromal artery Doppler characteristics and serum hormone levels in patients with Behçet's Disease

Cıl

Karabulut²,

Koçak³

2009

Diagn Interv Radiol

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 92%

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Assesment of ovarian stromal artery Doppler characteristics and serum hormone levels in patients with Behçet's Disease

Cıl

Karabulut²,

Koçak³

2009

Diagn Interv Radiol

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“…[11] In some studies, it has been suggested that there is a correlation between high serum prolactin levels and BD activity. [5,12] The elevated levels of prolactin may contribute to disease activity by augmenting immune processes. Proença et al [12] suggested that prolactin can play a role in BD pathogenesis and disease expression, especially in complete-type BD.…”

Section: Discussionmentioning

confidence: 99%

An Evaluation of Hormone Levels in Behçet’s Disease

et al. 2012

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Amaç: Bu çalışmada, Behçet hastalığında (BH) hipofizyal, tiroidal, adrenal ve gonadal hormonların bazal serum düzeyleri ile bu hormonların hastalık aktivitesi arasındaki ilişkileri değerlendirildi. Hastalar ve yöntemler:Kırk üç hasta (22 erkek, 21 kadın; ort. yaş 34 yıl; dağılım 21-46 yıl), hastalık aktivitesi ve oküler tutulum varlığına göre dört gruba ayrılarak değerlendirildi: Aktif BH (n=27), inaktif BH (n=16); oküler tutulum (n=14) ve oküler tutulum olmayanlar (n=29). Negatif kontrol grubu olarak benzer yaş ve cinsiyette 40 sağlıklı birey (18 erkek, 22 kadın) değerlendirmeye alındı. Pozitif kontrol grubuna ise 16 (2 erkek, 14 kadın) sistemik lupus eritematozus hastası dahil edildi. Çalışmaya alınan tüm bireylerde triiyodotironin, tiroksin, tiroid stimüle edici hormon, follikül stimüle edici hormon, lüteinize edici hormon, büyüme hormonu (GH), dihidroepiandrosteron sülfat (DHEAS), östradiol, testosteron, bazal kortizol, prolaktin (PRL) ve adrenokortikotropik hormon düzeyleri değerlendirildi. Bulgular:Negatif kontrol grubu ile BH grupları arasında, hipofizyal, tiroidal, adrenal ve gonadal hormonların bazal serum düzeylerine göre klinik bulgularda herhangi bir anlamlı değişiklik saptanmadı. Hormon düzeyleri ile hastalık aktivitesi ve oküler tutulum ilişkisine bakıldığında ise, oküler tutulumu olan her iki cinsiyetteki BH hastalarında PRL ve GH değerlerinin anlamlı yüksek, kadın hastalarda ise DHEAS seviyelerinin anlamlı düşük olduğu bulundu. Sonuç:Vaskülitik bir hastalık olmasına karşın BH'nin endokrinolojik sisteme majör bir etkisi olmadığı söylenebilir. Bununla birlikte, PRL, GH ve DHEAS düzeyleri ile oküler tutulumu olan BH arasında saptanmış olan ilişkinin irdelenmesi için geniş ölçekli çalışmalara gereksinim vardır.Anahtar sözcükler: Behçet hastalığı; hastalık aktivitesi; hormon düzeyleri; oküler tutulum; vaskülit.Objectives: This study aims to evaluate the basal serum levels of the hypophysial, thyroidal, adrenal, and gonadal hormones and the disease activity in patients with Behçet's disease (BD). Patients and methods:Forty-three patients (22 males, 21 females; mean age 34 years; range 21 to 46 years) were divided into the following four groups according to the disease activity and presence of ocular involvement: Active BD (n=27), inactive BD (n=16), those with ocular involvement (n=14), and those without ocular involvement (n=29). A group of 40 (18 male, 22 female) healthy subjects matched according to age and gender were used as the negative control group. A positive control group (two males and 14 females) consisted of 16 patients with systemic lupus erythematosus. Triiodothyronin, thyroxin, the thyroid-stimulating hormone, the folliclestimulating hormone, the luteinizing hormone, the growth hormone (GH), dihydroepiandrosterone sulphate (DHEAS), estradiol, testosterone, basal cortisol, prolactin (PRL), and the adrenocorticotropic hormone were evaluated in all subjects. Results:No clinically significant differences were found between the BD groups and negative control group in terms of the basal serum...

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“…In one of these studies Çil et al found no significant difference in terms of hormone levels between the Behcet and control groups [10]. However in another study, Proençha et al reported that serum prolactin levels were significantly higher in BD patients versus controls [11]. Another study by Atasoy et al also had declared that patients with active BD had higher serum prolactin levels than the inactive and control groups.…”

Section: Behcet's Disease and Hypophysismentioning

confidence: 99%

Behcet's Disease and Endocrine System

Özhan

Sezer

2012

Pathology Research International

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Behcet's disease (BD) is a chronic disease which is characterized by recurrent oral apthous ulcerations, recurrent genital ulcerations, skin eruptions, ocular involvements and other various systemic manifestations as well as systemic vasculitis. Endocrine involvement in BD regarding various systems can be seen. Hypophysis is one of the best and dense vascularized organs of the body, thus it is likely that it can be affected by BD. Not only anterior hypophysis functions, but posterior hypophysis functions as well can be affected. As BD is a disease of autoimmune process, it may be possible that adrenal insufficiency or alterations in the cortisol levels could be expected. Another concern is whether or not there is insulin resistance in patients with BD. The avaliable data suggests that there is an increased susceptibility to insulin resistance in patients with BD.

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Serum Prolactin Levels and Behçet Disease

Abstract: Results suggest the role of prolactin in BD pathogenesis and its association with disease expression, especially in complete-type BD.

Cited by 17 publications

References 9 publications

Assesment of ovarian stromal artery Doppler characteristics and serum hormone levels in patients with Behçet's Disease

Assesment of ovarian stromal artery Doppler characteristics and serum hormone levels in patients with Behçet's Disease

An Evaluation of Hormone Levels in Behçet’s Disease

Behcet's Disease and Endocrine System

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