Severe Impairment of Primary but Not Memory Responses to Influenza Viral Antigens in Aged Mice: Costimulation in Vivo Partially Reverses Impaired Primary Immune Responses

Sambhara, Suryaprakash; Kurichh, Anjna; Miranda, Renata Lima de; James, Olive; Underdown, Brian J.; Klein, Michel; Tartaglia, Jim; Burt, David S.

doi:10.1006/cimm.2001.1799

Cited by 33 publications

(18 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, it is possible that the DC-stimulating activity of influenza VLPs may augment the induction of antibody responses. In support of this, it has been shown that induction of antibody responses by influenza vaccines can be augmented through providing co-stimulation of DCs during immunization by using a co-polymer adjuvant (Katz et al, 2000), an immunostimulant patch containing bacterial heat-liable enterotoxin (Guebre-Xabier et al, 2004), a modified vaccinia virus expressing co-stimulatory molecules CD80 and CD86 (Sambhara et al, 2001), or immunostimulating complexes (Sambhara et al, 1998). As immunosenescence in the aged population is also manifested by reduced antigen presenting activity of DCs (Plowden et al, 2004; Sambhara et al, 2001), the DC-stimulating activity of influenza VLPs makes it particularly attractive for vaccination of elderly humans against influenza virus infection.…”

Section: Discussionmentioning

confidence: 99%

Immunization by influenza virus-like particles protects aged mice against lethal influenza virus challenge

Wen

Gao

et al. 2009

Antiviral Research

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Immunization by influenza virus-like particles protects aged mice against lethal influenza virus challenge

Wen

Gao

et al. 2009

Antiviral Research

View full text Add to dashboard Cite

show abstract

“…At the same time the ability to mount immune responses, in particular to neo-Ags, has been shown to be impaired and may result in decreased or inconsistent vaccine responses (45,46). Such impaired immune responsiveness is not due to reduced absolute numbers of lymphocytes, which are maintained at a remarkably constant level throughout life (3,4).…”

Section: Discussionmentioning

confidence: 99%

Direct Measurement of T Cell Subset Kinetics In Vivo in Elderly Men and Women

Wallace

Zhang

Ghattas

et al. 2004

The Journal of Immunology

103

View full text Add to dashboard Cite

The age-associated decline in immunocompetence is paralleled by changes in the proportions of PBL subpopulations. In turn, the size and composition of the peripheral lymphocyte pool is determined by input from the thymus and bone marrow and by the balance of proliferation and death in each lymphocyte subpopulation. We compared the kinetics of lymphocyte subtypes in young (seven of eight CMV seronegative) and healthy elderly human subjects (six of seven CMV seropositive), using deuterated glucose DNA labeling in vivo to measure rates of T cell proliferation and disappearance. For CD45RO+ cells of both CD4+ and CD8+ subtypes and for CD4+CD45RA+ cells the kinetics of proliferation and disappearance were remarkably similar between elderly and young subjects. In the young, the kinetics of CD8+CD45RA+ cells with a naive phenotype resembled those of CD4+CD45RA+ cells. However, CD8+CD45RA+ T cells from the elderly exhibited a predominantly primed phenotype, and for this subset, although the proliferation rate was similar to that of other CD45RA+ cells, the disappearance rate of labeled cells was greatly decreased compared with that of all other T cell subsets. Our data provide a direct demonstration that there are no substantial changes in in vivo kinetics for most T cell populations in healthy elderly compared with young subjects. However, primed CD8+CD45RA+ cells show unusual kinetic properties, indicating the persistence of these cells in the blood and dissociation of proliferation from disappearance.

show abstract

“…Antigen processing can occur in the endosome for both MHC class II [62] and class I presentation [63], possibly by the recently described cross-presentation pathway [64][65][66]. ISCOMs have been shown to elicit high titer long-lasting antibodies and strong helper and CTL responses in different models [67][68][69][70]. Protective immunity has been generated in a variety of experimental models of infection [71][72][73], including toxoplasmosis and Epstein-Barr virusinduced tumors.…”

Section: Saponins (Quil-a Iscom and Qs-21)mentioning

confidence: 99%