Severe vitamin D deficiency in chronic renal failure patients on peritoneal dialysis

Taşkapan, Hülya; Ersoy, Fevzi; Passadakis, Ploumis; Tam, Paul; Memmos, D E; Katopodis, Konstantinos P.; Özener, Çeti̇n; Akçiçek, Fehmi; Çamsarı, Taner; Ateş, Kenan; Ataman, Rezzan; Vlachojannis, John G.; Dombros, Nicholas; Utaş, Cengiz; Tekin, Mustafa; Bozfakioğlu, Semra; Wu, Gengze; Karayaylalı, İbrahim; Arinsoy, T; Stathakis, Charalampos; Yavuz, Mahmut; Tsakiris, Dimitrios; Dimitriades, Athanasios; Yılmaz, Mehmet Emin; Gültekin, Meral; Oreopoulos, Dimitrios G.

doi:10.5414/cnp66247

Cited by 49 publications

(38 citation statements)

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“…In haemodialysis patients, similarly, it has been demonstrated that some patients may remain vitamin D deficient despite even IV vitamin D replacement therapy [30]. Similar findings have been published for peritoneal dialysis patients remaining in calcitriol and/or calcidiol deficient despite replacement therapy [31]. These findings may be due to increased rate of consumption or insufficient dosage but we believe that further studies certainly are needed to clarify the underlying mechanism.…”

Section: Discussionsupporting

confidence: 60%

FGF-23, α-Klotho Gene Polymorphism and Their Relationship with the Markers of Bone Metabolism in Chronic Peritoneal Dialysis Patients

et al. 2015

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Objective: The aim of the present study was to evaluate the variations of some major bone metabolism markers with reference to klotho gene polymorphism (KGP) and bone mineral density (BMD) values in patients on chronic peritoneal dialysis (CPD). Materials and Methods:In 51 CPD patients and 40 healthy persons, assays for intact parathormone (iPTH), fibroblast growth factor 23 (FGF-23), osteoprotegerin (OPG), osteocalcin (OC), procollagen type-1 N terminal propeptide (PINP), beta-crosslaps (beta CTx ), tartrate resistant acid phosphatase (TRAP5b), bone alkaline phosphatase (BAP), 1,25(OH)D3, and 25(OH)D3 and a-klotho gene mutations were performed. Results:In CPD patients, 1,25(OH)D3 and 25(OH)D3 deficiency rates were 96% and 94% respectively. iPTH (249 pg/mL vs 39 pg/mL) and FGF-23 (1089 RU/mL vs 153 RU/mL), OPG, OC, PINP, beta CTx, TRAP5b levels were significantly higher in patients. iPTH levels and wholebody BMD values were negatively correlated in patients. The rate of KGP was similar in all groups. Conclusion:In CPD patients, besides vitamin D deficiency, high levels of OPG, OC, PINP, beta CTx, TRAP5b were evident. Positive correlation between iPTH levels and BAP and PINP levels suggested a diagnostic value for those markers during the management of CKD MBD. On the other hand, high serum TRAP5b concentrations did not seem to be affected by neither calcitriol treatment nor the severity of hyperparathyroidism. iPTH and FGF-23 levels and whole-body BMD values showed a significant negative correlation. We were unable to show any correlation between KGP and any of the CKD-MBD parameters measured in this study.Keywords: Peritoneal dialysis, fibroblast growth factor 23, klotho gene polymorphism, bone mineral density, beta CTx Özet Amaç: Çalışmamızda kronik periton diyalizi (KPD) hastalarında klotho gen polimorfizmi (KGP) ve kemik mineral yoğunluğu (KMY) ile bazı major kemik metabolizma belirteçleri arasındaki ilişkinin araş-tırılması amaçlanmıştır. Gereç ve Yöntem:Çalışmaya dahil edilen 51 KPD hastası ve 40 sağ-lıklı kontrol grubunda intakt parathormon (iPTH), fibroblast büyüme faktör (FGF-23), osteoprotogerin (OPG), osteokalsin (OK), prokollajen tip-1 N terminal propeptid (PINP), beta-crosslaps (beta KTx), tartarate resistan asid fosfataz (TRAF5b), kemik alkalen fosfataz (KAF), 1,25(OH)D3, 25(OH)D3 ve a-klotho gen mutasyonları ölçüldü.Bulgular: 51 KPD hastasında 1,25(OH)D3 ve 25(OH)D3 eksikliği oranı sırasıyla %96 ve %94 olarak tespit edildi. iPTH (249 pg/mL ve 39 pg/mL) ve FGF-23 (1089 RU/mL ve 153 RU/mL), OPG, OK, PINP, beta CTx, TRAP5b seviyeleri hastalarda istatistiksel olarak anlamlı derecede daha yüksek bulundu. Hastalarda iPTH seviyeleri ve tüm vücut KMY arasında negatif korelasyon tespit edildi. KGP oranı gruplar arasında benzer bulundu.Sonuç: Kronik periton diyalizi hastalarında D vitamin eksikliğine ek olarak, OPG, OK, PINP, beta CTx, TRAP5b düzeyleri yüksek saptandı. iPTH seviyeleri ile KAF ve PINP arasındaki pozitif korelasyon bu belirteçlerin kronik böbrek hastalarındaki (KBH) kemik mineral hast...

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Section: Discussionsupporting

confidence: 60%

FGF-23, α-Klotho Gene Polymorphism and Their Relationship with the Markers of Bone Metabolism in Chronic Peritoneal Dialysis Patients

et al. 2015

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“…This has been demonstrated in a number of studies, including predialysis [9], hemodialysis (HD) [10], and peritoneal dialysis (PD) patients [11]. Taskapan et al [12] evaluated 25(OH)D3 levels in 273 chronic PD patients by a cross-sectional, multicenter study, which is the most comprehensive study in the literature and has been supported by other studies showing low 25(OH)D3 levels in PD patients [12][13][14][15].…”

Section: Introductionmentioning

confidence: 93%

Loss via peritoneal fluid as a factor for low 25(OH)D3 level in peritoneal dialysis patients

et al. 2009

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“…In the study by Dobnig et al 2 which excluded patients with chronic kidney disease, mean PTH levels were 36% higher in the group with the lowest 25-hydroxy-vitamin D levels. 19,20 Similarly, no correlation was detected in our analyses evaluating PTH and vitamin D level. Vitamin D defi ciency has been associated with low bone mineral density and an increased risk for fracture.…”

Section: Discussionmentioning

confidence: 46%

“…Studies conducted in dialysis patients have also yielded confl icting results. 13,19 In our analyses of dialysis patients, we were able to detect a weak positive association between albumin and vitamin D level.…”

Section: Discussionmentioning

confidence: 79%

Vitamin D deficiency in dialysis patients and its effect on various disease markers

Korkor¹,

Bretzmann²,

Eastwood

2009

Dialysis & Transplantation

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Longitudinal linkages between intentional exposure to x‐rated material and sexually aggressive behavior were examined among youth 10–15 year olds surveyed nationally in the United States. At Wave 1 in 2006, participants (n = 1,588) were queried about these exposures and outcomes in the preceding 12 months. Wave 2 data (n = 1,206) were collected approximately 12 months after Wave 1 and Wave 3 data (n = 1,159) were collected approximately 24 months after Wave 1. Thus, data for this project represent a 36‐month time frame. A marginal model with generalized estimating equations was used to represent the population‐average odds of sexually aggressive behavior over the 36 months as a function of exposure to x‐rated material over the same time and to account for clustering in the data within person over time. An average of 5% of youth reported perpetrating sexually aggressive behavior and 23% of youth reported intentional exposure to x‐rated material. After adjusting for other potentially influential proximal (i.e., sexual aggression victimization) and distal characteristics (e.g., substance use), we found that intentional exposure to violent x‐rated material over time predicted an almost 6‐fold increase in the odds of self‐reported sexually aggressive behavior (aOR: 5.8, 95% CI: 3.2, 10.5), whereas exposure to nonviolent x‐rated material was not statistically significantly related (aOR: 1.7, 95% CI: 0.94, 2.9). Associations were similar for boys and girls (boys nonviolent x‐rated material aOR = 2.0, 95% CI: 0.8, 4.7; violent x‐rated material aOR = 6.5, 95% CI: 2.7, 15.3; girls nonviolent x‐rated material aOR = 1.2, 95% CI: 0.5, 3.2; violet x‐rated material aOR = 6.1, 95% CI: 2.5, 14.8). Aggr. Behav. 37:1–18, 2011. © 2010 Wiley‐Liss, Inc.

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Severe vitamin D deficiency in chronic renal failure patients on peritoneal dialysis

Cited by 49 publications

References 0 publications

FGF-23, α-Klotho Gene Polymorphism and Their Relationship with the Markers of Bone Metabolism in Chronic Peritoneal Dialysis Patients

FGF-23, α-Klotho Gene Polymorphism and Their Relationship with the Markers of Bone Metabolism in Chronic Peritoneal Dialysis Patients

Loss via peritoneal fluid as a factor for low 25(OH)D3 level in peritoneal dialysis patients

Vitamin D deficiency in dialysis patients and its effect on various disease markers

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