Sex disparity of cerebral white matter hyperintensity in the hypertensive elderly: The <scp>Shanghai Changfeng</scp> study

Wang, Liangqi; Lin, Hung-Ching; Zhao, Zehua; Chen, Lingyan; Wu, Li; Liu, Ting; Li, Jing; Huang, Chu-Chung; Peng, Yifeng; Lo, Chun-Yi Zac; Gao, Xin

doi:10.1002/hbm.26196

Cited by 5 publications

(1 citation statement)

References 38 publications

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“…In atherosclerosis/age-related CSVD, the density of smooth muscle in the intima-media decreases, leading to the narrowing of the arterial lumen due to brous-hyaline deposits. This type of disease is closely associated with systemic vascular disease and shares common risk factors, such as age-related diabetes mellitus and hypertension 35 . Hypertension also damages the small blood vessels of the brain and triggers the expression of hypoxia-sensitive genes (HIF-1α, etc.)…”

Section: Discussionmentioning

confidence: 99%

A Novel Logistic Model for Predicting Risk Factors and Contribution of Cerebral Small Vessel Disease

Liu,

Xu,

Liang

et al. 2023

Preprint

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Background: Cerebral small vessel disease (CSVD) results in pathological alterations in the small arteries or veins of the brain, thereby significantly impairing brain functionality. This study aimed to examine the causative factors of small vessel disease and ultimately determined the proportion of each risk factor for CSVD by constructing a multivariate model based on stepwise regression. Methods: A total of 164 hospitalized patients were involved in this study. The study period was from January 2022 to March 2023.The patients were analyzed for the presence of CSVD by magnetic resonance imaging (MRI). The presence of CSVD in patients was determined by magnetic resonance imaging, and history, coagulation indices, renal function related to CSVD, and serum biochemistry and Hcy results were analyzed. Results: 164 patients were included in the safety analysis set, 73 ( 44.5% ) cases with CSVD and 91 ( 55.5% ) cases with no. of patients, and the median age of the patients was 66 ( 49 - 86 ) years.. The results of multivariate logistic model showed that yes of hypertension ( OR = 10.94%, 95% CI: 3.80% ~ 35.57%, P ＜0.001 ), HbA1c ( OR = 3.05%, 95% CI: 1.54% ~ 7.51%, P = 0.005 ), HCY ( OR = 1.45%, 95% CI: 1.22% ~ 1.82%, P ＜ 0.001 ), CRP ( OR = 2.21%, 95% CI: 1.25% ~ 4.10%, P = 0.008 ), TG ( OR = 3.80%, 95% CI: 1.62% ~ 10.00%, P = 0.004 ), and TC ( OR = 1.90%, 95% CI: 1.17% ~ 3.25%, P = 0.013 ) were risk factors for CSVD morbidity. The marginal R-squared ( R 2 M ) was 0.467. Among all the determinants, the weight of HCY ( 60.60% ) was maximum, followed by HbA1c ( 27.84% ).The quasi-curves plotted by using bootstrap method (999 times) showed a good agreement between the predictive model and the actual observations. Conclusion: Hypertension, HbA1c, HCY, CRP, TG and TC were risk factors for CSVD morbidity, and controlling the above indicators within a reasonable range will help to reduce the incidence of CSVD.

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Section: Discussionmentioning

confidence: 99%

A Novel Logistic Model for Predicting Risk Factors and Contribution of Cerebral Small Vessel Disease

Liu,

Xu,

Liang

et al. 2023

Preprint

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Sex disparity of cerebral white matter hyperintensity in the hypertensive elderly: The Shanghai Changfeng study

Wang

Lin

Zhao

et al. 2022

Human Brain Mapping

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White matter hyperintensity (WMH) is associated with vascular hemodynamic alterations and reflects white matter injury. To date, the sex difference of tract‐specific WMH and the relationship between high blood pressure (BP) and tract‐specific WMH remain unclear. We recruited 515 subjects from the Shanghai Changfeng study (range 53–89 years, mean age 67.33 years). Systolic and diastolic blood pressure (SBP and DBP) were collected and used to calculate pulse pressure (PP). Magnetic resonance T1 and T2 FLAIR images were acquired to measure WMH and calculate WMH index. The ANCOVA test was performed to test the difference between sexes, and the linear regression model was used to examine the associations between BP and WMH index. Men showed higher WMH index than women in all white matter tracts (p < .001, respectively) except for the bilateral superior longitudinal fasciculus (SLF) and its left temporal part (tSLF). High SBP and PP was associated with a lower WMH index on the left corticospinal tract (CST), SLF, tSLF and right cingulum in hippocampus (p ≤ .001, respectively) in women, while high DBP was associated with a higher WMH index on the bilateral CST (left p < .001; right p = .001), left inferior longitudinal fasciculus (p < .001) and inferior fronto‐occipital fasciculus (p = .002) in men. Men tend to have more WMH compared to women. A high SBP/PP relates to a lower WMH burden in women. This suggests that women could benefit from higher blood pressure in older age.

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Common protein-altering variant in GFAP is associated with white matter lesions in the older Japanese population

Furuta,

Akiyama,

Hirabayashi

et al. 2024

npj Genom. Med.

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The genetic architecture of white matter lesions (WMLs) in Asian populations has not been well-characterized. Here, we performed a genome-wide association study (GWAS) to identify loci associated with the WML volume. Brain MRI and DNA samples were collected from 9479 participants in the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD). The GWAS confirmed three known WML-associated loci ( SH3PXD2A , GFAP , and TRIM47 ). The lead variant of GFAP was a common missense variant (p.D295N) in East Asians. Meta-GWAS using the publicly available summary statistics of UK Biobank identified one previously unreported locus 6q23.2 ( SLC2A12 ). Integration with expression quantitative trait locus data implied the newly identified locus affects SLC2A12 expression. The effect sizes of 20 lead variants at the WML-associated loci were moderately correlated between JPSC-AD and UK Biobank. These results indicate that the alteration in GFAP protein caused by the common missense variant in East Asians influences the WML volume.

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Sex disparity of cerebral white matter hyperintensity in the hypertensive elderly: The Shanghai Changfeng study

Cited by 5 publications

References 38 publications

A Novel Logistic Model for Predicting Risk Factors and Contribution of Cerebral Small Vessel Disease

A Novel Logistic Model for Predicting Risk Factors and Contribution of Cerebral Small Vessel Disease

Sex disparity of cerebral white matter hyperintensity in the hypertensive elderly: The Shanghai Changfeng study

Common protein-altering variant in GFAP is associated with white matter lesions in the older Japanese population

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