Sheet-like Janus hemostatic dressings with synergistic effects of cardanol hemostasis and quaternary ammonium salt antibacterial action

Zhang, Yuxia; Lu, Xiaoyu; Chi, Chongyi; Zheng, Yanyan; Chen, Qinhui

doi:10.1039/d2tb02082c

Cited by 6 publications

(1 citation statement)

References 37 publications

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“…As shown in Figure 4f, the adhesion strength of the ColTA (RBC) adhesive was significantly larger than that of the ColTA (blood), ColTA (plasma), and ColTA (PRP) adhesives, suggesting the dominant rule of RBCs in the blood-enhanced adhesion performance. The phenol hydroxyl groups and amino groups on the ColTA adhesive polymers can absorb RBCs (especially membrane protein) through electrostatic interactions, [6,[43][44][45][46] subsequently leading to the aggregation of the polymer chains with RBCs. During the lapshear teats, the RBCs trapped and coagulated within the adhesive polymers can resist deformation (Figure 4g), thereby contributing to higher adhesion strength.…”

Section: Blood-enhanced Adhesion Properties Of the Colta Adhesivementioning

confidence: 99%

Hydro‐Sensitive, In Situ Ultrafast Physical Self‐Gelatinizing, and Red Blood Cells Strengthened Hemostatic Adhesive Powder with Antibiosis and Immunoregulation for Wound Repair

Shang,

Yan,

et al. 2023

Advanced Science

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Immediate and effective hemostatic treatments for complex bleeding wounds are an urgent clinical demand. Hemostatic materials with characteristics of adhesion, sealing, anti‐infection, and concrescence promotion have drawn growing concerns. However, pure natural multifunctional hemostatic materials with in situ ultrafast self‐gelation are rarely reported. In this study, a hydro‐sensitive collagen/tannic acid (ColTA) natural hemostatic powder is developed that can in situ self‐gel to form adhesive by the non‐covalent crosslinking between tannic acid (TA) and collagen (Col) in liquids. The physical interactions endow ColTA adhesive with the characteristics of instantaneous formation and high adhesion at various substrate surfaces. Crucially, ColTA powder adhesive shows an enhanced adhesion performance in the presence of blood due to the electrostatic interactions between ColTA adhesive and red blood cells, conducive to effective in situ sealing and rapid hemostasis. The biocompatible and hemocompatible ColTA adhesive can effectively control bleeding and seal the wounds of the caudal vein, liver, heart, and femoral arteries in rats. Furthermore, the low‐cost and ready‐to‐use ColTA adhesive powder also possesses good antibacterial and inhibiting biofilm formation ability, and can efficiently regulate immune response by the NF‐κB pathway to promote wound repair, making it a highly promising hemostatic material with great potential for biomedical applications.

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Section: Blood-enhanced Adhesion Properties Of the Colta Adhesivementioning

confidence: 99%

Hydro‐Sensitive, In Situ Ultrafast Physical Self‐Gelatinizing, and Red Blood Cells Strengthened Hemostatic Adhesive Powder with Antibiosis and Immunoregulation for Wound Repair

Shang,

Yan,

et al. 2023

Advanced Science

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Quaternary Ammonium Compounds and Their Composites in Antimicrobial Applications

Yao,

Ye,

Zhang

et al. 2024

Adv Materials Inter

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Quaternary ammonium compounds (QACs) are well‐known for their antimicrobial properties, but their widespread use is limited due to suboptimal antimicrobial efficiency and safety concerns. Recent progress in materials science has paved the way for the development of QAC‐based composites (QACCs). QACCs with diverse compositions have shown enhanced antimicrobial effectiveness and biosafety for various applications, such as food packaging, capacitive deionization, and household antimicrobials. This review provides a comprehensive summary of the synthesis approaches and different types of QACCs. Moreover, this review examines their antimicrobial applications, taking the underlying structure‐activity relationship into consideration. In addition, this perspectives are presented on the remaining challenges and future research directions for the further development of QACCs. It is expected that this review will provide a valuable reference for the design of next generation QACC‐based antimicrobial agents.

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Rapid hemostatic antibacterial self-gelling powder based on methacryloylsulfonyl betaine and quaternized carboxymethyl chitosan

Deng,

Wang,

Xing

2023

Journal of the Mechanical Behavior of Biomedical Materials

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Sheet-like Janus hemostatic dressings with synergistic effects of cardanol hemostasis and quaternary ammonium salt antibacterial action

Abstract: It is key important to stop bleeding and anti-infection for the people with trauma. Here, an anisotropic Janus mesoporous silica nanosheet (MSNS) with different functional groups were designed and prepared....

Cited by 6 publications

References 37 publications

Hydro‐Sensitive, In Situ Ultrafast Physical Self‐Gelatinizing, and Red Blood Cells Strengthened Hemostatic Adhesive Powder with Antibiosis and Immunoregulation for Wound Repair

Hydro‐Sensitive, In Situ Ultrafast Physical Self‐Gelatinizing, and Red Blood Cells Strengthened Hemostatic Adhesive Powder with Antibiosis and Immunoregulation for Wound Repair

Quaternary Ammonium Compounds and Their Composites in Antimicrobial Applications

Rapid hemostatic antibacterial self-gelling powder based on methacryloylsulfonyl betaine and quaternized carboxymethyl chitosan

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