Short-wavelength cone-opponent retinal ganglion cells in mammals

Marshak, David; Mills, Steven

doi:10.1017/s095252381300031x

Cited by 34 publications

(38 citation statements)

References 87 publications

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“…4-6) was not predicted from BCs, which instead displayed an approximately balanced mix of blue-On and -Off circuits (Zimmermann et al, 2018). The near-complete absence of blue-On signals in zebrafish RGCs is also in stark contrast to the importance of multiple blue-On RGC circuits in mammals (Marshak and Mills, 2014;Mills et al, 2014) including in primates (Calkins et al, 1998;Dacey, 1996;Dacey and Lee, 1994). Next, while many of the dominant spectral opponencies observed in RGCs (Fig.…”

Section: Figure 11 | Putative 'Prey-capture-rgcs' Revealed Following mentioning

confidence: 91%

What the Zebrafish’s Eye Tells the Zebrafish’s Brain: Retinal Ganglion Cells for Prey Capture and Colour Vision

Zhou

Bear

Roberts

et al. 2020

Preprint

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In vertebrate vision, the tetrachromatic larval zebrafish permits non-invasive monitoring and manipulating of neural activity across the nervous system in vivo during ongoing behaviour. However, despite a perhaps unparalleled understanding of links between zebrafish brain circuits and visual behaviours, comparatively little is known about what their eyes send to the brain in the first place via retinal ganglion cells (RGCs). Major gaps in knowledge include any information on spectral coding, and information on potentially critical variations in RGC properties across the retinal surface to acknowledge asymmetries in the statistics of natural visual space and behavioural demands.Here, we use in vivo two photon (2P) imaging during hyperspectral visual stimulation as well as photolabeling of RGCs to provide the first eye-wide functional and anatomical census of RGCs in larval zebrafish.We find that RGCs' functional and structural properties differ across the eye and include a notable population of UV-responsive On-sustained RGCs that are only found in the acute zone, likely to support visual prey capture of UV-bright zooplankton. Next, approximately half of RGCs display diverse forms of colour opponency -long in excess of what would be required to satisfy traditional models of colour vision. However, most information on spectral contrast was intermixed with temporal information. To consolidate this series of unexpected findings, we propose that zebrafish may use a novel "dual-achromatic" strategy segregated by a spectrally intermediate background subtraction system. Specifically, our data is consistent with a model where traditional achromatic image-forming vision is mainly driven by longwavelength sensitive circuits, while in parallel UV-sensitive circuits serve a second achromatic system of foreground-vision that serves prey capture and, potentially, predator evasion.

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Section: Figure 11 | Putative 'Prey-capture-rgcs' Revealed Following mentioning

confidence: 91%

What the Zebrafish’s Eye Tells the Zebrafish’s Brain: Retinal Ganglion Cells for Prey Capture and Colour Vision

Zhou

Bear

Roberts

et al. 2020

Preprint

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“…45,46 Multi-electrode recordings in the macaque far peripheral retina find weak S-cone input to OFF midget RGCs, consistent with non-selective input from S-OFF and L/M-OFF midget bipolar cells; 32 however, pure S-cone center, OFF midget RGCs have remained elusive in single cell electrophysiology 20,48,69 and electroretinography. 43,44 The discrepancies in evidence for S-OFF midget RGCs may be due to differences in species, 52 retinal eccentricity and methodology, thus, here, we sought both anatomical and physiological confirmation in the macaque retina. Because color vision, 53 spatial acuity 71 and midget RGC response properties vary considerably with eccentricity, 65 we focused our efforts on the central retina where our research is most relevant to human visual perception.…”

Section: Introductionmentioning

confidence: 99%

An S-cone circuit for edge detection in the primate retina

Patterson

Kuchenbecker

Anderson

et al. 2019

Preprint

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Midget retinal ganglion cells (RGCs) are the most common RGC type in the primate retina. Their responses mediate both color and spatial vision, yet the specific links between midget RGC responses and visual perception are unclear. Previous research on the dual roles of midget RGCs has focused on those comparing long (L) vs. middle (M) wavelength sensitive cones. However, there is evidence for several other rare midget RGC subtypes receiving S-cone input, but their role in color and spatial vision is uncertain. Here, we confirm the existence of the single S-cone center OFF midget RGC circuit in the central retina of macaque monkey both structurally and functionally, by combining single cell electrophysiology with 3D electron microscopy reconstructions of the upstream circuitry. Like the well-studied L vs. M midget RGCs, the S-OFF midget RGCs have a centersurround receptive field consistent with a role in spatial vision. While spectral opponency in a primate RGC is classically assumed to contribute to hue perception, a role supporting edge detection is more consistent with the S-OFF midget RGC receptive field structure and studies of hue perception.

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“…One cone pigment has a peak sensitivity at about 510 nm, and the other is maximally sensitive in the ultraviolet with a peak at about 370 nm [29]. Color opponency as described above has also been found in mice [30]. …”

Section: Introductionmentioning

confidence: 99%

Gender differences in cerebral metabolism for color processing in mice: A PET/MRI Study

et al. 2017

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IntroductionColor processing is a central component of mammalian vision. Gender-related differences of color processing revealed by non-invasive functional transcranial Doppler ultrasound suggested right hemisphere pattern for blue/yellow chromatic opponency by men, and a left hemisphere pattern by women.Materials and MethodsThe present study measured the accumulation of [18F]fluorodeoxyglucose ([18F]FDG) in mouse brain using small animal positron emission tomography and magnetic resonance imaging (PET/MRI) with statistical parametric mapping (SPM) during light stimulation with blue and yellow filters compared to darkness condition.ResultsPET revealed a reverse pattern relative to dark condition compared to previous human studies: Male mice presented with left visual cortex dominance for blue through the right eye, while female mice presented with right visual cortex dominance for blue through the left eye. We applied statistical parametric mapping (SPM) to examine gender differences in activated architectonic areas within the orbital and medial prefrontal cortex and related cortical and sub-cortical areas that lead to the striatum, medial thalamus and other brain areas. The metabolic connectivity of the orbital and medial prefrontal cortex evoked by blue stimulation spread through a wide range of brain structures implicated in viscerosensory and visceromotor systems in the left intra-hemispheric regions in male, but in the right-to-left inter-hemispheric regions in female mice. Color functional ocular dominance plasticity was noted in the right eye in male mice but in the left eye in female mice.ConclusionsThis study of color processing in an animal model could be applied in the study of the role of gender differences in brain disease.

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Short-wavelength cone-opponent retinal ganglion cells in mammals

Cited by 34 publications

References 87 publications

What the Zebrafish’s Eye Tells the Zebrafish’s Brain: Retinal Ganglion Cells for Prey Capture and Colour Vision

What the Zebrafish’s Eye Tells the Zebrafish’s Brain: Retinal Ganglion Cells for Prey Capture and Colour Vision

An S-cone circuit for edge detection in the primate retina

Gender differences in cerebral metabolism for color processing in mice: A PET/MRI Study

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