Should Low-intensity Extracorporeal Shockwave Therapy Be the First-line Erectile Dysfunction Treatment for Nonresponders to Phosphodiesterase Type 5 Inhibition?

Patel, Premal; Fode, Mikkel; Lue, Tom F.; Ramasamy, Ranjith

doi:10.1016/j.euf.2019.02.004

Cited by 8 publications

(6 citation statements)

References 16 publications

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“…In general, a focused extracorporeal shock wave (fESW) is generated electrohydraulically, electromagnetically, or piezoelectrically, followed by converging it into a focal tissue zone (29). As an acoustic wave, fESW is characterized by its high pressure of more than 1,000 bar (100 MPa), an extremely short rise time (<10 ns), a short duration (<10 ms), and a broad frequency spectrum (16-20 MHz) (30)(31)(32). Unlike fESW, radial extracorporeal shock wave (rESW) does not possess the shock wave characteristics of a short rise time, a high peak pressure, and non-linearity.…”

Section: Principles Of Eswtmentioning

confidence: 99%

Application of extracorporeal shock wave therapy in nervous system diseases: A review

Guo

Hai

2022

Front. Neurol.

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Neurological disorders are one of the leading causes of morbidity and mortality worldwide, and their therapeutic options remain limited. Recent animal and clinical studies have shown the potential of extracorporeal shock wave therapy (ESWT) as an innovative, safe, and cost-effective option to treat neurological disorders. Moreover, the cellular and molecular mechanism of ESWT has been proposed to better understand the regeneration and repairment of neurological disorders by ESWT. In this review, we discuss the principles of ESWT, the animal and clinical studies involving the use of ESWT to treat central and peripheral nervous system diseases, and the proposed cellular and molecular mechanism of ESWT. We also discuss the challenges encountered when applying ESWT to the human brain and spinal cord and the new potential applications of ESWT in treating neurological disorders.

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Section: Principles Of Eswtmentioning

confidence: 99%

Application of extracorporeal shock wave therapy in nervous system diseases: A review

Guo

Hai

2022

Front. Neurol.

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“…18 Therefore, patients with moderate ED may be an ideal population for the application of regenerative treatment modalities in an attempt to delay ED progression. 19 Indeed, our findings indicate that patients with moderate ED may benefit from the regenerative properties of LiST. We also aimed to contextualize the magnitude of LiST efficacy in patients with moderate ED.…”

Section: Discussionmentioning

confidence: 65%

“…18 Therefore, patients with moderate ED may be an ideal population for the application of regenerative treatment modalities in an attempt to delay ED progression. 19…”

Section: Discussionmentioning

confidence: 99%

The Effect of Low-Intensity Shock Wave Therapy on Moderate Erectile Dysfunction: A Double-Blind, Randomized, Sham-Controlled Clinical Trial

et al. 2022

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“…As it is known, PDE5I are the first-line treatment for ED. Recently, ESWT has been used effectively in nonresponder PDE5I ED treatment [18].…”

Section: Discussionmentioning

confidence: 99%

“…Patel et al [18] determined that following parameters affected the biological reactions: Intensity of energy flow (mJ/mm 2 ); number of shock; frequency of device (Hz); frequency and interval of treatment; existing tissue/progenitor cell content (influenced by age and diseases); shape and focus of shockwaves; diameter of efficient therapeutic areas; and energy weakening; they reported that these parameters influenced efficiency of LI-ESWT in ED [18].…”

Section: Discussionmentioning

confidence: 99%

Comparison of focused and unfocused ESWT in treatment of erectile dysfunction

et al. 2019

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Recently, extracorporeal shock wave therapy (ESWT) is more commonly used in noninvasive treatment of erectile dysfunction (ED). There is no definitive treatment protocol on the use of ESWT. In this study, we aimed to compare focused and unfocused ESWT in ED. We created two groups, each including 20 patients with similar demographics. Focused ESWT is performed in one group, while unfocused ESWT is performed for the other group. Patients are assessed with IIEF-5 and EHS. Mean score of IIEF-5 was increased by 6.3 ± 3.3 (p < .05) from 9.6 ± 2.9 to 15.0 ± 5.0 in 3-month follow-up in the unfocused group. In the focused group, IIEF-5 score increased by 5.34 in average from 10.01 ± 2.5 to 15.4 ± 3.1. In conclusion, IIEF-5 score was significantly higher in the unfocused ESWT group than the focused ESWT group.

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Should Low-intensity Extracorporeal Shockwave Therapy Be the First-line Erectile Dysfunction Treatment for Nonresponders to Phosphodiesterase Type 5 Inhibition?

Cited by 8 publications

References 16 publications

Application of extracorporeal shock wave therapy in nervous system diseases: A review

Application of extracorporeal shock wave therapy in nervous system diseases: A review

The Effect of Low-Intensity Shock Wave Therapy on Moderate Erectile Dysfunction: A Double-Blind, Randomized, Sham-Controlled Clinical Trial

Comparison of focused and unfocused ESWT in treatment of erectile dysfunction

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