Shoyu polysaccharides from soy sauce improve quality of life for patients with seasonal allergic rhinitis: A double-blind placebo-controlled clinical study

Promotive effect of Shoyu polysaccharides from soy sauce on iron absorption in animals and humans

“…For 4 weeks, each patient took 4 capsules daily (2 capsules each morning and evening). SPS were prepared from an ethanol precipitate of raw soy sauce as described previously (3)(4)(5)(6). SPS powder was encapsulated into gelatin capsules (hard type, size 3, dark caramel; Sankyo Co., Ltd., Fuji, Shizuoka, Japan).…”

“…Recently, we reported that SPS have strong anti-allergic activities (3) and enhance the functions of macrophages and lymphocytes (4) in vitro and in vivo. Furthermore, oral supplementation with SPS was an effective intervention for patients with allergic rhinitis in two double-blind placebo-controlled clinical studies (5,6). However, many of the ingredients of soy sauce are unknown and the biological activities of soy sauce itself remain to be elucidated.…”

Effects of Polysaccharide Derived from Black Currant on Relieving Clinical Symptoms of Japanese Cedar Pollinosis: A Randomized Double-Blind, Placebo-Controlled Trial

“…In addition, Xiao et al 14) have reported that yogurt supplement BB536 significantly inhibited ocular symptoms of Japanese cedar pollinosis. Kobayashi et al 7) have investigated the efficacy of shoyu polysaccharides in alleviating Japanese cedar pollinosis symptoms, and observed overall effects centered on nasal symptom, including sneezing and nasal obstruction.…”

Composition variability in soy-derived dietary supplements designated for menopausal symptom prevention

“…It has also been shown in vivo that a diet containing less than 22.4 g of stachyose/kg body weight and less than 2 g of raffinose/kg did not alter digestibility or increase flatulence, indicating that a low intake of soy oligosaccharides did not exert undesirable effects compared with a high intake [77]. In another recent study, patients with seasonal allergic rhinitis treated with 600 mg of soy sauce polysaccharides showed a significant reduction in the total symptom score [78]. Thus, the presence of raffinose and stachyose, even in low quantity in the dietary supplements may influence the biological effects attributed to isoflavones, or exert independent biological activity.…”