Sign of Leser-Trélat in association with laryngeal carcinoma

Nyati, Asha; Kalwaniya, Sarita; Jain, Suresh; Soni, Bajrang

doi:10.4103/0378-6323.164222

Cited by 4 publications

(4 citation statements)

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“…The commonest associated malignancy with SLT is gastrointestinal adenocarcinomas and lymphoproliferative disorders [2,5] . Only five cases of LTS in head and neck have been reported in literature (Table 1) with four cases of SCC of the larynx and one of the nasopharyngx [6][7][8][9] . Thus, the current case is the fifth case of LTS with laryngeal SCC and sixth in head and neck SCC.…”

Section: Discussionmentioning

confidence: 99%

Leser-Trélat syndrome associated with cancer larynx : A case report

Ahmed

Abdelfattah

et al. 2018

Egyptian Journal of Ear, Nose, Throat and Allied Sciences

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Leser-Trélat syndrome (LTS) is a rare cutaneous paraneoplastic syndrome that barely affects patients with head and neck cancer. Here we present a case of 58-years old male presented with skin manifestation consistent with a sign of Leser-Trélat. A close investigation of the patient revealed that he had a recurrent laryngeal squamous cell carcinoma. The described case is the fifth case of a Leser-Trélat syndrome with squamous cell carcinoma of the larynx and the sixth to be reported in the head and neck squamous cell carcinoma. Thus sudden development of paraneoplastic dermatoses is recurrently a forewarning progression of the malignancy.

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Section: Discussionmentioning

confidence: 99%

Leser-Trélat syndrome associated with cancer larynx : A case report

Ahmed

Abdelfattah

et al. 2018

Egyptian Journal of Ear, Nose, Throat and Allied Sciences

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“…The most frequently reported malignancies associated with the Leser-Trélat sign are stomach cancer, lymphoma, and gastrointestinal adenocarcinoma. There are also reports of occurrence in cases of laryngeal cancer [40].…”

Section: Leser-trélatmentioning

confidence: 99%

Paraneoplastic Syndromes Associated with Laryngeal Cancer

et al. 2019

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Objectives: Paraneoplastic syndromes occur rarely in association with laryngeal cancer. When present, the syndrome may be the first sign of the malignancy. The aim of the present study was to review and report on all published cases in the international literature. Methods: A search of PubMed was conducted for ''paraneoplastic syndromes in laryngeal cancer'' without any restrictions on language or publication year. The full texts of all relevant articles were reviewed and all cases of paraneoplastic syndromes associated with any type of laryngeal cancer were extracted and analyzed. Results: We identified 59 cases of paraneoplastic syndromes related to laryngeal cancer in the literature published from 1963 until recently. There were 46 squamous cell carcinomas and 10 neuroendocrine carcinomas. Twenty-two of the paraneoplastic syndromes involved the endocrine system, 21 were dermatologic or cutaneous, 8 neurologic, 5 osteoarticular or rheumatologic, 1 ocular, 1 muscular, and 1 hematologic. Treatment strategies included surgery, radiotherapy, chemotherapy, and often multimodal therapy, depending on the histology and stage of the laryngeal cancer. Conclusions: Because of their rarity, paraneoplastic syndromes associated with laryngeal cancer are difficult to diagnose. By presenting and systematically reviewing all published cases in the international literature, the present review may help clinicians to recognize them and to suspect the diagnosis of laryngeal cancer at an earlier stage than otherwise might be possible.

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“…Leser-Trélat sign (TLS) is a rare paraneoplastic syndrome characterized by the sudden eruption of multiple seborrheic keratoses (QS) in patients with underlying malignancy [1][2][3][4][5][6][7][8][9][10][11][12][13] hidden or known 14 . These benign skin lesions rapidly increase in number and size over a period of weeks to months.…”

Section: Introductionmentioning

confidence: 99%

Leser-Trelat Sign and Its Main Features: A Systematic Literature Review

Leles¹,

Capop²,

Crispim³

2021

JHS

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Leser-Trélat sign (TLS) is a rare paraneoplastic syndrome characterized by the sudden onset of multiple seborrheic keratoses (QS), indicating an underlying malignancy. The cancers most associated with TLS occur in the gastrointestinal tract and, as they are more common in elderly people, some authors question its legitimacy as a predictor of malignancy. So, this study aimed to compile all case reports published in the last ten years, to analyze their common characteristics, such as the sex and age of the people affected, as well as the main associated malignancies, the evolution of skin lesions and its relationship with the onset of cancer. A bibliographic search was carried out in the databases: Medical Literature Analysis and Retrieval System Online (Medline) via PubMed, Scientific Electronic Library Online (SciELO) and Latin American and Caribbean Literature in Health Sciences (LILACS), using the term: Leser-Trelat. Based on the selection criteria, 13 articles were included in this study and it was found that the disease is more common in the elderly, with no sex predilection. The most common location of QS was on the back and chest, with sudden onset and with a higher occurrence of gastric and hepatocellular adenocarcinoma, in addition to cutaneous T lymphoma. Despite the need for more studies to improve the understanding of the disease, it is concluded that TLS must indeed be considered a paraneoplastic syndrome and, therefore, an omen for screening for hidden malignancies.

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Sign of Leser-Trélat in association with laryngeal carcinoma

Cited by 4 publications

References 0 publications

Leser-Trélat syndrome associated with cancer larynx : A case report

Leser-Trélat syndrome associated with cancer larynx : A case report

Paraneoplastic Syndromes Associated with Laryngeal Cancer

Leser-Trelat Sign and Its Main Features: A Systematic Literature Review

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