Simple markers for subclinical inflammation in the different phases of bipolar affective disorder

Yıldız, Mesut; Batmaz, Sedat; Songur, Emrah; Sahin, Şevki; Demir, Osman

doi:10.1590/0101-60830000000101

Cited by 7 publications

(11 citation statements)

References 31 publications

(41 reference statements)

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“…In a study with a similar method by Yıldız et al, PLR was found not to be different in all patient groups compared to the control group in consistent with our results. It has also been reported that NLR was higher only in patients with the euthymic and manic phase and there was no difference between the depressive group and control group in terms of NLR [33]. Including only drug-free patients for at least 1 month in the current study may lead to different results in the patients with depressive phase in terms of NLR.…”

Section: Discussionmentioning

confidence: 70%

“…Studies in which inflammatory mechanisms play a role in the aetiology of BD are becoming increasingly important. According to our knowledge, three studies have investigated the association between NLR or PLR and BD to date [31][32][33]. However, the results of these studies vary according to different episodes of BD.…”

Section: Discussionmentioning

confidence: 99%

“…In another study, patients with BD demonstrated increased NLR compared to controls [32]. In a study by Yildiz et al [33], NLR has been found to be higher in manic and euthymic patients, while depressive patients did not differ from controls in terms of NLR.…”

Section: Introductionmentioning

confidence: 95%

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Neutrophil/lymphocyte and platelet/lymphocyte ratios in all mood states of bipolar disorder

Ayhan¹,

Çiçek²,

İnanlı³

et al. 2017

Psychiatry and Clinical Psychopharmacology

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Objectives: This study aims at researching the inflammatory cells and their ratios as inflammation markers in different phases of patients with bipolar disorder (BD). Methods: In this retrospective study, 79 manic, 61 depressed, 59 euthymic drug-naive patients with BD, and 86 control subjects have been evaluated for their complete blood count. Results: Neutrophil/lymphocyte ratio (NLR) was found to be significantly higher in manic, euthymic, and depressed patients with BD compared to control group. However, no difference was found between all patient and control groups regarding platelet/lymphocyte ratio (PLR). There was no difference among different phases of patient groups in terms of NLR and PLR. Conclusions: Our findings suggest that inflammatory process may have a role in all mood episodes of BD and NLR may be a useful trait inflammation marker for BD independent of mood episodes. However, further studies need to be conducted on the effect of inflammatory mechanisms on mood states of BD. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

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Neutrophil/lymphocyte and platelet/lymphocyte ratios in all mood states of bipolar disorder

Ayhan¹,

Çiçek²,

İnanlı³

et al. 2017

Psychiatry and Clinical Psychopharmacology

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“…Many researchers have investigated the PLT levels in psychiatric disorders. In many studies, the differences between BD and UD patients and control groups were not statistically significant [5,8,20,22,23]. Kalelioğlu et al found higher PLT counts in the control group than among BD patients [21].…”

Section: Discussionmentioning

confidence: 99%

PDW and RDW are new parameters for bipolar episodes and unipolar depression

Gündoğmuş¹,

Algül²,

Karagöz³

et al. 2018

Psychiatry and Clinical Psychopharmacology

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INTRODUCTION: Bipolar disorder (BD) and unipolar depression (UD) are complex and multifactorial mental disorders characterized by mood swings, disability, and impaired quality of life. In the present study, we researched the roles of inflammatory cells and their value as inflammation markers in BD and UD. OBJECTIVE: Sixty-nine manic, 60 euthymic, and 70 UD patients and 60 sex-matched healthy volunteers (control group) were retrospectively analysed. Platelet (PLT), platelet distribution width (PDW), and red cell distribution width (RDW) levels were measured in four groups. The aim of this study was to evaluate PLT, PDW, and RDW levels patient with UD and two different phases of BD: euthymic and manic. RESULTS: In our study, 199 patients and 60 controls were included. There were no differences between the patients and the healthy control group participants in terms of age and sex. The bipolar episodes and the UD patient group were statistically significantly different from the healthy controls in terms of PLT, PDW, and RDW. CONCLUSION: Our study is the first in the literature to compare blood PLT, PDW, and RDW levels in bipolar episodes, UD patients, and healthy control groups. We believe that the levels of PLT, PDW, and RDW can be used as novel markers of bipolar episodes and UD. More detailed and larger prospective clinical studies are required to confirm these findings.

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“…On the other hand, several hemogram parameters have been investigated to evaluate the inflammatory states in both organic (27,28) and psychiatric disorders in recent publications. There are several studies investigating the hemogram parameters of adult patients with a major depressive disorder (29,30), bipolar disorder (31) and schizophrenia (32). Basic points in the investigation of these parameters are based on the ease of use and economical in daily practice.…”

mentioning

confidence: 99%

Simple Peripheral Markers for Inflammation in Drug-Naive, Comorbidity-Free Adolescents with Obsessive–Compulsive Disorder

Uçar¹,

Murat²,

Eray³

2019

Eastern J Med

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Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder with recurrent obsessions and/or compulsions that cause distress, time-consuming and/or significant disruption (1). The prevalence of OCD is %1-3 (2). OCD is divided into 2 groups according to the age of onset; early onset (12-14 years) and late onset (20-22 years) (3,4). Childhood-onset OCD is suggested to be distinguished with late-onset OCD by different etiopathogenic mechanisms (4,5). The pathophysiology of OCD is still unknown, recent studies have focused primarily on neurotransmitters, such as serotonin, dopamine, and glutamate (6,7). The previous studies have focused on environmental factors such as psychosocial stressors, trauma, and other infectious and their effects on inflammatory process. The inflammatory processes alter gene expression in a way that influences the serotoninergic and dopaminergic systems, catecholamine modulation, and glutamate pathways (8,9). Although the etiopathology is still unclear, these changes in the paths that process corticostriatal information are thought to be because of epigenetic mechanisms and have a causative role in OCD symptoms (10). Studies regarding the pathophysiology of OCD have emphasized the importance of immunological mechanisms (10-12). The relation between Group A β-hemolytic streptococcus infections and OCD onset or exacerbation in some children also show that immunological factors play a role in the etiology of OCD (13). Besides to streptococcus infection, other infectious diseases such as Borrelia burgdorferi, mycoplasma, Toxoplasma gondii, or Borna disease virus have been related with OCD (11,14).

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Simple markers for subclinical inflammation in the different phases of bipolar affective disorder

Cited by 7 publications

References 31 publications

Neutrophil/lymphocyte and platelet/lymphocyte ratios in all mood states of bipolar disorder

Neutrophil/lymphocyte and platelet/lymphocyte ratios in all mood states of bipolar disorder

PDW and RDW are new parameters for bipolar episodes and unipolar depression

Simple Peripheral Markers for Inflammation in Drug-Naive, Comorbidity-Free Adolescents with Obsessive–Compulsive Disorder

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