Simulation of multipolar fiber selective neural stimulation using intrafascicular electrodes

Meier, J.H.; Rotten, W.L.C.; Zoutman, A.E.; Boom, H.B.K.; Bergveld, Piet

doi:10.1109/10.121643

Cited by 45 publications

(20 citation statements)

References 25 publications

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“…4 shows the nerve being placed inside a medium with low conductivity. As has been predicted [5], [9], [13], the potential values within this (nearly) insulated nerve are considerably higher than in the previous situation. Fig.…”

Section: A the Extracellular Potential Field Of An Activesupporting

confidence: 62%

“…The conductivities of the different tissues are given realistic values (for a detailed discussion on the conductivities; see [9]). The radii of the fascicle and the epineurium are given values as measured in histological sections of rat peroneal nerve.…”

Section: A Calculation Of the Extracellular Potential Field Of An Acmentioning

confidence: 99%

“…It has been shown that in case of electrical stimulation the highest degree of selectivity can be achieved with dense three-dimensional "lattices" of electrodes, placed inside the fascicles [9]- [11], [18], [19]. These intraneural stimulation electrodes, however, can also be used to monitor nerve signals, for example, to be used in future closed-loop control systems for rehabilitation.…”

mentioning

confidence: 99%

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Extracellular potentials from active myelinated fibers inside insulated and noninsulated peripheral nerve

Meier

Rutten

Boom

1998

IEEE Trans. Biomed. Eng.

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Abstract-A model is presented that calculates the singlefiber extracellular field and action potential (ap) of an active myelinated nerve fiber placed centrally or eccentrically inside a nerve with a cylindrical geometry, representing essentially a onefascicle nerve. This one-fascicle nerve has the dimensions and conductivities of the rat peroneal nerve branch. The results show a wide variety of wave shapes to be measured, depending on the position of the intraneural electrode with respect to the fiber axis and to the nodes of Ranvier and depending on the presence of an isolating cuff around the nerve. Action potential shapes may range from the "classical" quasi-biphasic one, to more triphasic, or even more complicated in the case of a short insulating cuff being present around the nerve. In the latter case, when measured bipolarly, ap-wave shapes become almost monophasic.Index Terms-Action potential (ap) recording, extracellular ap modeling, functional electric stimulation and recording, nerve cuff, selective recording.

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Section: A the Extracellular Potential Field Of An Activesupporting

confidence: 62%

Section: A Calculation Of the Extracellular Potential Field Of An Acmentioning

confidence: 99%

mentioning

confidence: 99%

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Extracellular potentials from active myelinated fibers inside insulated and noninsulated peripheral nerve

Meier

Rutten

Boom

1998

IEEE Trans. Biomed. Eng.

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“…These experiments employed direct stimulation where a metal loop and nerve cuff electrodes were placed around the nerve. Sev eral chronically implanted electrode designs have been proposed in the literature with the goal of nerve fascicle and spatial recruitment selectivity [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

The effect of stimulus current pulse width on nerve fiber size recruitment patterns

Szlavik

Bruin

1999

Medical Engineering & Physics

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There have been theoretical studies presented that postulate a change in the stimulus current amplitude required to recruit nerve fibers with different stimulus current pulse widths. Based on these theoretical predictions, it has been suggested that the stimulus pulse width parameter may be used to selectively recruit fibers of different sizes and that this selectivity should increase with increasing distance from the stimulus electrode. In this paper, a simulation study of the recruitment patterns of a population of motor nerve fibers with a histologically accurate fiber diameter distribution is presented. Nerve fiber excitation simulations coupled with a time varying field simulation suggest that, for surface stimulation, there is only a marginal selectivity achievable in the average nerve fiber diameter that is recruited across the range of commonly used stimulus pulse widths but this selectivity also increases with increased electrode distance. Experimental evidence consisting of estimates of nerve fiber diameter based on motor unit latency studies is also presented that is consistent with the predictions made by the electromagnetic field and nerve fiber excitation simulations.

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“…The potential fields are calculated by solving the homogeneous partial differential equations under appropriate boundary conditions. Solutions to this problem can be derived analytically when the volume geometry and electrode configuration are simple [27][28][29][30][31]. However, when realistic geometries are considered, numerical simulations are required, such as finite element (FE) or finite difference models [24,[32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

Effects of Microelectrode Array Configuration and Position on the Threshold in Electrical Extracellular Stimulation of Single Nerve Fiber：a Modeling Study

Zhao¹,

Wang²,

Lv³

2013

PIER B

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Abstract-A transient finite-element model has been presented to simulate extracellular potential stimulating in a neural tissue by a nonplanar microelectrode array (MEA). This model allows simulating the extracellular potential and transmembrane voltage by means of a single transient computation performed within single finite element (FE) software. The differential effects of the configuration and position of MEA in electrical extracellular stimulation are analyzed theoretically. 3-D models of single nerve fiber and different MEA are used for the computation of the stimulation induced field potential, whereas a cable model of a nerve fibre is used for the calculation of the transmembrane voltage of the nerve fiber. The position of MEA and the spacing of the microelectrodes are varied while mono-, bi-, tri-, and penta-polar MEAs are applied. The model predicts that the lowest stimulation voltage threshold is obtained in the stimulation with penta-polar MEA. Moreover, the relationships, which exist between the thresholds of the electrical extracellular stimulation and the parameters including position of the electrode array and the spacing of the microelectrodes in array, are studied and obtained.

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Simulation of multipolar fiber selective neural stimulation using intrafascicular electrodes

Cited by 45 publications

References 25 publications

Extracellular potentials from active myelinated fibers inside insulated and noninsulated peripheral nerve

Extracellular potentials from active myelinated fibers inside insulated and noninsulated peripheral nerve

The effect of stimulus current pulse width on nerve fiber size recruitment patterns

Effects of Microelectrode Array Configuration and Position on the Threshold in Electrical Extracellular Stimulation of Single Nerve Fiber：a Modeling Study

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