Simulation of pulmonary ventilation and its control by negative feedback

Dolenšek, Janez; Runovc, Franc; Kordaš, M.

doi:10.1016/j.compbiomed.2004.02.002

Cited by 10 publications

(4 citation statements)

References 14 publications

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“…However, as we know, respiratory dynamics cannot be measured directly. Consequently, people usually adopt the modeling and simulation of ventilated respiratory system …”

Section: Introductionmentioning

confidence: 99%

“…Consequently, people usually adopt the modeling and simulation of ventilated respiratory system. [7][8][9] According to most researches having been performed so far, it is assumed that human beings have only 1 lung, not 2 lungs (namely, left lung and right lung) as we should have. [10][11][12] Then, the influence of parameters of each lung on the dynamics of the entire respiratory system cannot be obtained, which is essential to analyze the dynamics of the entire respiratory system.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Numerical simulation of volume‐controlled mechanical ventilated respiratory system with 2 different lungs

Shi

Cai

Zhang

2016

Numer Methods Biomed Eng

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Mechanical ventilation is a key therapy for patients who cannot breathe adequately by themselves, and dynamics of mechanical ventilation system is of great significance for life support of patients. Recently, models of mechanical ventilated respiratory system with 1 lung are used to simulate the respiratory system of patients. However, humans have 2 lungs. When the respiratory characteristics of 2 lungs are different, a single-lung model cannot reflect real respiratory system. In this paper, to illustrate dynamic characteristics of mechanical ventilated respiratory system with 2 different lungs, we propose a mathematical model of mechanical ventilated respiratory system with 2 different lungs and conduct experiments to verify the model. Furthermore, we study the dynamics of mechanical ventilated respiratory system with 2 different lungs. This research study can be used for improving the efficiency and safety of volume-controlled mechanical ventilation system.

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“…However, as we know, respiratory dynamics cannot be measured directly. Consequently, people usually adopt the modeling and simulation of ventilated respiratory system …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Numerical simulation of volume‐controlled mechanical ventilated respiratory system with 2 different lungs

Shi

Cai

Zhang

2016

Numer Methods Biomed Eng

View full text Add to dashboard Cite

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“…Nowadays, dynamic characteristics of respiratory system and models of different medical conditions are referred to in pulmonary diagnostics and treatments [21–29]. However, mechanical respiratory properties cannot be measured directly; therefore, they are generally represented by means of lumped parameters, such as the overall breathing resistance, R , and compliance, C [30].…”

Section: Introductionmentioning

confidence: 99%

Pressure Dynamic Characteristics of Pressure Controlled Ventilation System of a Lung Simulator

Shi

Ren

Cai

et al. 2014

Computational and Mathematical Methods in Medicine

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Mechanical ventilation is an important life support treatment of critically ill patients, and air pressure dynamics of human lung affect ventilation treatment effects. In this paper, in order to obtain the influences of seven key parameters of mechanical ventilation system on the pressure dynamics of human lung, firstly, mechanical ventilation system was considered as a pure pneumatic system, and then its mathematical model was set up. Furthermore, to verify the mathematical model, a prototype mechanical ventilation system of a lung simulator was proposed for experimental study. Last, simulation and experimental studies on the air flow dynamic of the mechanical ventilation system were done, and then the pressure dynamic characteristics of the mechanical system were obtained. The study can be referred to in the pulmonary diagnostics, treatment, and design of various medical devices or diagnostic systems.

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“…However, in analog modelling physical electrical models have been replaced by computer analysis of electronic analog circuitry. Then they have been applied to various physiological systems (Bošnjak & Kordaš, 2002;Dolenšek et al, 2005), to study also cardiovascular physiology (Rupnik et al, 2002), including mechanisms of compensation (Podnar et al, 2002) and principles of homeostasis, i. e. negative feedback mechanisms (Podnar et al, 2004). Recently, the equivalent circuit simulating the cardiovascular system was further upgraded to simulate, as close as possible, conditions in man in vivo.…”

Section: Introductionmentioning

confidence: 99%