Simultaneous analysis of aspartame and its hydrolysis products of Coca-Cola Zero by on-line postcolumn derivation fluorescence detection and ultraviolet detection coupled two-dimensional high-performance liquid chromatography

Cheng, Cheanyeh; Wu, Shing-Chen

doi:10.1016/j.chroma.2011.03.033

Cited by 26 publications

(20 citation statements)

References 46 publications

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“…The Th LOD and limit of quantitation (LOQ) for ASP were 1.3 and 4.3 μg/mL, respectively, with a linear range spanning 0-50 μg/mL. The LODs and Th LOQs for L-and D-aspartic acid were 0.16 and 0.17 μg/mL and for L-and D-phenylalanine were 0.52 and 0.55 μg/mL, respectively [40].…”

Section: Hplc-uv-vis/dad/elsd Detectionmentioning

confidence: 95%

See 1 more Smart Citation

Recent Analytical Methods for the Analysis of Sweeteners in Food: A Regulatory Perspective

Shah

Jager

2016

Food Safety

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Section: Hplc-uv-vis/dad/elsd Detectionmentioning

confidence: 95%

“…A novel technique was reported by Cheng and Wu [40] for the determination of ASP and its hydrolysis products in Coca-Cola Zero. The authors Th described a two-dimensional HPLC-UV method using a C8 RP column for the first dimension and determination of ASP.…”

Section: Hplc-uv-vis/dad/elsd Detectionmentioning

confidence: 99%

Recent Analytical Methods for the Analysis of Sweeteners in Food: A Regulatory Perspective

Shah

Jager

2016

Food Safety

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“…Most widely-used detection protocols for aspartame employ capillary electrophoreses [16][17][18] and high performance liquid chromatography (HPLC) techniques [19]; however, these techniques require highly sophisticated equipment and time-consuming preparatory and pretreatment steps [20]. Other reports involve the co-immobilization of enzymes such as alcohol oxidase (AOX) and carboxyl esterase (CaE) on screen printed electrodes using various crosslinking chemistries [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Detection of aspartame via microsphere-patterned and molecularly imprinted polymer arrays

Tiu

Pernites

Tiu

et al. 2016

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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A colloidal sphere-patterned polyterthiophene thin film sensor with high binding affinity and selectivity towards aspartame was fabricated using a technique combining molecular imprinting and colloidal sphere lithography (CSL). The successful imprinting of aspartame into electropolymerized molecularly imprinted polymer generated artificial recognition sites capable of rebinding aspartame into the microporous film, which was sensitively detected using quartz crystal microbalance measurements. The resulting sensor exhibited a good linear response after exposure to aspartame concentrations ranging from 12.5 μM to 200 μM and limit of detection of ~31 μM. It also demonstrated a high selectivity towards aspartame as compared to other peptidebased analogs including alanine-phenylalanine (Ala-Phe), alanine-glutamine (Ala-Gln), glycylglycine (Gly-Gly), and arginylglycylaspartic acid (RGD). The formation of the highly ordered micropatterned surface was induced and monitored in situ by electrochemical quartz crystal microbalance and atomic force microscopy. Analyte imprinting and removal were characterized using X-ray photoelectron spectroscopy. Based on molecular modeling (semiempirical AM1 quantum calculations), the formation of a stable pre-polymerization complex due to the strong hydrogen bonding interactions between the terthiophene monomer and aspartame played a key role in the effective aspartame imprinting and detection.

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“…The most widely used detection method for the additives in colas and juices is high-performance liquid chromatography (HPLC) 10 and synchronous fluorescence spectroscopy. 11 However, to the best of our knowledge, there is no report concerning additive measurements by matrix-assisted laser desorption ionization mass spectrometry (MALDI MS), although MALDI is advantageous for detecting molecules in many impurities.…”

Section: Introductionmentioning

confidence: 99%

Detection and Quantification of 4-Methyliniidazole in Cola by Matrix-assisted Laser Desorption Ionization Mass Spectrometry with Fe2O3 Nanoparticles on Zeolite

et al. 2018

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Food additives generally used in carbonated drinks, such as 4-methylimidazole (4MI), caffeine (Caf ), citric acid (CA), and aspartame (Apm), were measured by matrix-assisted laser desorption ionization mass spectrometry (MALDI MS) using nanometer-sized particles of iron oxide (Fe2O3 NPs). The quantification of 4MI in Coca Cola (C-cola) was carried out. In order to improve the reproducibility of the peak intensities, Fe2O3 NPs loaded on ZSM5 zeolite were used as the matrix for quantification. By using 2-ethylimidazole (2EI) as the internal standard, the amount of 4MI in C-cola was determined to range from 88 to 65 μg/355 mL. The results agree with the published value (approx. 72 μg/355 mL). It was found that MALDI using Fe2O3 was applicable to the quantification of 4MI in C-cola.

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Simultaneous analysis of aspartame and its hydrolysis products of Coca-Cola Zero by on-line postcolumn derivation fluorescence detection and ultraviolet detection coupled two-dimensional high-performance liquid chromatography

Cited by 26 publications

References 46 publications

Recent Analytical Methods for the Analysis of Sweeteners in Food: A Regulatory Perspective

Recent Analytical Methods for the Analysis of Sweeteners in Food: A Regulatory Perspective

Detection of aspartame via microsphere-patterned and molecularly imprinted polymer arrays

Detection and Quantification of 4-Methyliniidazole in Cola by Matrix-assisted Laser Desorption Ionization Mass Spectrometry with Fe2O3 Nanoparticles on Zeolite

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