Simultaneous preconcentration and determination of sulfonamide antibiotics in milk and yoghurt by dynamic pH junction focusing coupled with capillary electrophoresis

Semail, Nadhiratul-Farihin; Keyon, Aemi Syazwani Abdul; Saad, Bahruddin; Sijam, Kamaruzaman; Zain, Nur Nadhirah Mohamad; Lim, Vuanghao; Miskam, Mazidatulakmam; Abdullah, Wan Nazwanie Wan; Yahaya, Noorfatimah; Chen, David D. Y.

doi:10.1016/j.talanta.2021.122833

Cited by 49 publications

(22 citation statements)

References 31 publications

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“…At the same time, the HMIPIS can effectively extract SAs in an aqueous solution, avoiding the use of organic reagents. Compared with the methods established by other groups for the detection of sulfonamides (Table ), − the limits of detection and quantification of this method show certain limitations. However, this method can fully meet the requirements of the maximum residue limits (MRLs) of sulfonamide in honey samples of various countries.…”

Section: Resultsmentioning

confidence: 92%

Sulfonamide-Selective Ambient Mass Spectrometry Ion Source Obtained by Modification of an Iron Sheet with a Hydrophilic Molecularly Imprinted Polymer

Yang

Wang

et al. 2021

J. Agric. Food Chem.

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We have described a sulfonamide-selective ambient ion source coupled with electrospray ionization mass spectrometry (ESI-MS) for selective extraction and determination of trace sulfonamide antibiotics. It is obtained by modifying an iron sheet with a sulfadiazine-templated hydrophilic molecularly imprinted polymer (SF-HMIP). It behaves as both an online extractor and a MS ion source. Five sulfonamide antibiotics, including sulfamethoxazole (SMZ), sulfamerazine (SMR), sulfisoxazole (SIZ), sulfathiazole (ST), and sulfameter (SMD), were chosen to evaluate SF-HMIP coupled with ESI-MS, which showed good linearity in the range of 0.2–1000 ng/mL with correlation coefficient values (R 2) over 0.9946. The limits of detection (LODs) for analysis of pure water and honey were in the range of 0.1–0.2 and 0.2–1.5 ng/mL, respectively. Limits of quantitation (LOQs) for analysis of pure water and honey were in the range of 0.3–0.5 and 1.0–5.0 ng/mL, respectively. The results demonstrated that SF-HMIP combined with ESI-MS could be applied for the direct analysis of five trace sulfonamide compounds in honey and pure water with recoveries ranging from 76 to 129%.

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Section: Resultsmentioning

confidence: 92%

Sulfonamide-Selective Ambient Mass Spectrometry Ion Source Obtained by Modification of an Iron Sheet with a Hydrophilic Molecularly Imprinted Polymer

Yang

Wang

et al. 2021

J. Agric. Food Chem.

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“…For the separation of sulphonamides, most analysis methods focused on adding buffer additives such as β‐cyclodextrin, sodium dodecyl sulfate, etc., (Table S1)[53, 54]. In this research, we have used the Azo‐Co‐PSS@column prepared for the separation of five sulfonamides.…”

Section: Resultsmentioning

confidence: 99%

“…Also, the effect of the addition of ACN and voltage was optimized for the optimum resolution and analysis time under 5 min (Figure S5). For the separation of sulphonamides, most analysis methods focused on adding buffer additives such as β-cyclodextrin, sodium dodecyl sulfate, etc., (Table S1) [53,54]. In this research, we have used the Azo-Co-PSS@column prepared for the separation of five sulfonamides.…”

Section: 21mentioning

confidence: 99%

Preparation of open tubular capillary column covalently coated with polystyrene sulfonate with 4,4′‐Azobis(4‐cyanopentanoyl chloride) as polymerization initiator for electrochromatographic separation of alkaloids, sulfonamides, and peptides

Naithani

Cheddah

Yang

et al. 2023

J of Separation Science

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An open tubular capillary electrochromatography column covalently bonded with polystyrene sulfonate was prepared via in situ polymerization using functionalized Azo-initiator 4,4′-Azobis(4-cyanopentanoyl chloride). Scanning electron, fluorescence, and atomic force microscopy techniques showed the formation of a relatively rough layer of polymer. In addition, -CN and C = O stretching vibrations from infrared spectroscopy proved the successful immobilization of the azo-initiator through covalent bonding and X-ray photoelectron spectroscopy confirmed the elemental composition of the formed polymer layer. The prepared column was found to be appropriate for small and medium-sized molecules separation. Compared to bare fused silica capillary column higher selectivity and resolution were obtained for the separation of alkaloids, sulfonamides, and peptides as a result of the electrostatic and pi-pi stacking interactions between the small organic molecules and the coated column without compromising the electroosmotic flow mobility. Separation efficiency was also increased compared to the bare capillary for the separation of alkaloids (about 1.5 times). Moreover, intraday, inter-day, intra-batch, and inter-batch relative standard deviation values of retention time and peak area of peptides were within 2% and 10%, respectively, indicating good repeatability of the column preparation procedure. The developed method for the covalent bonding of polymers through a functionalized azo-initiator could represent a promising stable method for the preparation of an open tubular column.

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“…This dictates the need for its simultaneous determination with other members of this class. The techniques of HPLC liquid chromatography [5], thin layer chromatography [5], capillary electrochromatography [6], electrophoresis [7,8], and spectrophotometry [9] are used for the determination of 4-aminobenzenesulfonic acid derivatives. For the analysis of media with complex matrixes, including those containing several 4-aminobenzenesulfonic acid derivatives, hybrid methods combining extraction and chromatography with tandem mass-spectrometric [10][11][12] Polymers 2022, 14, 2545 2 of 21 or UV-detectors [13], extraction and electrophoresis with UV-detection [14], extraction and UV-Visible spectrometry [15,16] are commonly used.…”

Section: Introductionmentioning

confidence: 99%

Multisensory Systems Based on Perfluorosulfonic Acid Membranes Modified with Polyaniline and PEDOT for Multicomponent Analysis of Sulfacetamide Pharmaceuticals

et al. 2022

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The degradation of sulfacetamide with the formation of sulfanilamide leads to a deterioration in the quality of pharmaceuticals. In this work, potentiometric sensors for the simultaneous determination of sulfanilamide, sulfacetamide and inorganic ions, and for assessing the degradation of pharmaceuticals were developed. A multisensory approach was used for this purpose. The sensor cross-sensitivity to related analytes was achieved using perfluorosulfonic acid membranes with poly(3,4-ethylenedioxythiophene) or polyaniline as dopants. The composite membranes were prepared by oxidative polymerization and characterized using FTIR and UV-Vis spectroscopy, and SEM. The influence of the preparation procedure and the dopant concentration on the membrane hydrophilicity, ion-exchange capacity, water uptake, and transport properties was investigated. The characteristics of the potentiometric sensors in aqueous solutions containing sulfanilamide, sulfacetamide and alkali metals ions in a wide pH range were established. The introduction of proton-acceptor groups and π-conjugated moieties into the perfluorosulfonic acid membranes increased the sensor sensitivity to organic analytes. The relative errors of sulfacetamide and sulfanilamide determination in the UV-degraded eye drops were 1.2 to 1.4 and 1.7 to 4%, respectively, at relative standard deviation of 6 to 9%.

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Simultaneous preconcentration and determination of sulfonamide antibiotics in milk and yoghurt by dynamic pH junction focusing coupled with capillary electrophoresis

Cited by 49 publications

References 31 publications

Sulfonamide-Selective Ambient Mass Spectrometry Ion Source Obtained by Modification of an Iron Sheet with a Hydrophilic Molecularly Imprinted Polymer

Sulfonamide-Selective Ambient Mass Spectrometry Ion Source Obtained by Modification of an Iron Sheet with a Hydrophilic Molecularly Imprinted Polymer

Preparation of open tubular capillary column covalently coated with polystyrene sulfonate with 4,4′‐Azobis(4‐cyanopentanoyl chloride) as polymerization initiator for electrochromatographic separation of alkaloids, sulfonamides, and peptides

Multisensory Systems Based on Perfluorosulfonic Acid Membranes Modified with Polyaniline and PEDOT for Multicomponent Analysis of Sulfacetamide Pharmaceuticals

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