Simultaneous screening and quantitation of 18 antihistamine drugs in blood by liquid chromatography ionspray tandem mass spectrometry

Gergov, Merja; Robson, J.N.; Ojanperä, Ilkka; Heinonen, Olli-Pekka; Vuori, Erkki

doi:10.1016/s0379-0738(01)00460-1

Cited by 71 publications

(42 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In another forensic application, 18 antihistamine drugs were screened, confirmed and quantitated in autopsy blood samples using the same macro (Auto MS/MS Builder for automatic DDE and library search) as in the application 1 [20]. In this study, screening was performed with multiple reaction monitoring (MRM) because the data were also used for quantitation of very low concentrations of antihistamines.…”

Section: Applicationmentioning

confidence: 99%

MS/MS-libraries with triple quadrupole-tandem mass spectrometers for drug identification and drug screening

Weinmann¹,

Gergov²,

Goerner³

2000

Analusis

View full text Add to dashboard Cite

Two MS/MS libraries of drugs created by electrospray ionisation (ESI) and collision-induced dissociation (CID) of the quasimolecular ionshave been developed with triple-quadrupole ionspray mass spectrometers. For both libraries three and four different collision energies were used, respectively, to obtain a variety of CID spectra, which were all included separately into the MS/MS libraries. The MS/MS product ion spectra of more than 400 drugs were acquired in positive or negative mode in two laboratories independently. Recently, one of these MS/MS libraries was applied successfully for the identification of drug metabolites and the other has been used for qualitative analysis of drugs in urine samples with data dependent experiments (DDE). In this work, the reproducibility of CID spectra has been tested with three instruments (including two different instruments) in three laboratories. For comparison of CID-spectra, library searching with a combination of the two libraries was performed and fit values were compared. With regard to library fit values CID-spectra were found to be highly reproducible between the instruments, when similar CID gas pressure and collision energy were applied. In addition, the long-time reproducibility of CID over 30 months with the API 365 was demonstrated. Furthermore, comparisons of in-source CID and CID by MS/MS was given. It can be concluded, that both MS/MS libraries created with APIs 365 can be used with both types of triple-quadrupole instruments from Sciex (API 365 and 2000) for drug identification. Two applications of these MS/MS spectra libraries in combination with data dependent experiments are summarised.

show abstract

Section: Applicationmentioning

confidence: 99%

MS/MS-libraries with triple quadrupole-tandem mass spectrometers for drug identification and drug screening

Weinmann¹,

Gergov²,

Goerner³

2000

Analusis

View full text Add to dashboard Cite

show abstract

“…Official method uses non-aqueous titrations for assay of this drug. Literature survey revealed that determination of Ebastine has been reported by RP-HPLC method 3 , liquid chromatography ionspray tandem mass spectrometry 4,5 , in single and combined dosage forms. Stability indicating spectrofluorimetric estimation of Ebastine has been also established 6,7 .…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of Uv Spectrophotometric Estimation of Ebastine in Bulk and Tablet Dosage Form Using Area Under Curve Method

Dahivadkar¹,

Jain²,

Gujar³

2013

Int. Res. J. Pharm.

View full text Add to dashboard Cite

The aim of this work is to develop a simple, accurate, reproducible and cost effective spectrophotometric method for determination of Ebastine in bulk and pharmaceutical dosage form. This method is basedon area under curve (AUC) in wavelength range of 247-257nm and method has followed linearity in the concentration range of 5-30μg/ml. Methanol was used as a solvent. The developed analytical method was validated as per International Conference on Harmonization (ICH) guidelines. The value of correlation coefficient (R 2 ) was 0.999. Limit of Detection and Limit of Quantitation were calculated as 0.78µg/ml and 2.37µg/ml, respectively. Results of the recovery studies showed good accuracy of the method. Validation results suggest that the developed method can be used for routine quality control studies for assay of Ebastine in bulk and tablet dosage form.

show abstract

“…In pharmaceutical dosage forms, it was quantified by ion -complex reactions [3], capillary electrophoresis [4][5][6], anodic voltammetry [7], new polymeric membrane [8,9] and HPLC with ultraviolet detection [10][11][12]. In biological fluids, fexofenadine hydrochloride has been determined employing anodic voltammetry 7 as well as HPLC with different detections, including ultraviolet [13], mass spectrometry [14][15][16] fluorescence [17] and spectrophotometric method [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Utility of Extracted Colored Ion – Associate Complexes Formation Reaction for the Determination of Fexofenadine Hydrochloride in Pure Forms and in Dosage Forms

Amin¹,

Ahmed²,

Mohamed³

2010

J Chem Eng Process Technol

View full text Add to dashboard Cite

Simultaneous screening and quantitation of 18 antihistamine drugs in blood by liquid chromatography ionspray tandem mass spectrometry

Cited by 71 publications

References 15 publications

MS/MS-libraries with triple quadrupole-tandem mass spectrometers for drug identification and drug screening

MS/MS-libraries with triple quadrupole-tandem mass spectrometers for drug identification and drug screening

Development and Validation of Uv Spectrophotometric Estimation of Ebastine in Bulk and Tablet Dosage Form Using Area Under Curve Method

Utility of Extracted Colored Ion – Associate Complexes Formation Reaction for the Determination of Fexofenadine Hydrochloride in Pure Forms and in Dosage Forms

Contact Info

Product

Resources

About