Single and combination nonhormonal chemotherapy in breast cancer

Carter, Stephen K.

doi:10.1002/1097-0142(197212)30:6<1543::aid-cncr2820300621>3.0.co;2-v

Cited by 138 publications

(22 citation statements)

References 25 publications

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“…The Eastern Co-Operative Oncology Group has demonstrated clearly the superiority of a combination of cyclophosphamide, methotrexate and 5-fluorouracil over L-phenylalanine mustard used singly (Canellos et al, 1974b). However, the response rate of 20% to L-phenylalanine mustard in this trial was inferior to the responses expected from any of the other agentF if they had been used singly (Carter, 1972), and so the trial did not prove that combinations are superior to single agents.…”

Section: Discussionmentioning

confidence: 64%

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Chemotherapy of advanced breast cancer: a controlled randomized trial of cyclophosphamide versus a four-drug combination

Rubens¹,

Knight²,

Hayward³

1975

Br J Cancer

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Summary.-Ninety-nine patients with advanced breast cancer were randomized to receive either cyclophosphamide continuously or a combination of cyclophosphamide, methotrexate, 5 -fluorouracil and vinblastine given intermittently. The number and duration of objective responses were greater in patients receiving the combination but the differences between the two treatments did not achieve formal significance. The combination was logistically easier to manage and produced less toxicity.

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Section: Discussionmentioning

confidence: 64%

“…5-fluorouracil, methotrexate and the vinca-alkaloids in breast cancer (Carter, 1972). Vinblastine was chosen rather than vincristine (which has been used more often) in order to avoid neurotoxicity during an anticipated long period of treatment.…”

Section: Methodsmentioning

confidence: 99%

Chemotherapy of advanced breast cancer: a controlled randomized trial of cyclophosphamide versus a four-drug combination

Rubens¹,

Knight²,

Hayward³

1975

Br J Cancer

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“…The anti-neoplastic activity of EC is thought to be mostly attributable to epirubicin because the response rate of metastatic breast cancers to EC is similar to that to epirubicin monotherapy (Ormrod et al 1999) and because the action of cyclophosphamide monotherapy is reported to be generally very low (Carter 1972). Anthracyclines including epirubicin exert their anti-neoplastic eVect through formation of a complex with DNA by intercalating the DNA strands and inhibiting the function of topoisomerase II-alpha, which leads to the induction of DNA damage and, Wnally, the inhibition of DNA replication (Capranico et al 1990).…”

Section: Discussionmentioning

confidence: 99%

Low LATS2 mRNA level can predict favorable response to epirubicin plus cyclophosphamide, but not to docetaxel, in breast cancers

Miyoshi

Taguchi

Tamaki

et al. 2007

J Cancer Res Clin Oncol

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“…4,5) Kalpaamruthaa is a Siddha formulation, which has been formulated in our laboratory. They contain Semecarpus anacardium LINN.…”

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confidence: 99%

Anticancer Effect of Kalpaamruthaa on Mammary Carcinoma in Rats with Reference to Glycoprotein Components, Lysosomal and Marker Enzymes

Veena

Shanthi

Sachdanandam

2006

Biological & Pharmaceutical Bulletin

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Cancer accounts for high morbidity and high mortality rate throughout the world. Cancer of breast is common in women in developed countries and more than 40% of all breast cancer cases are found in developing countries.1) Cancer is based on genetic and epigenetic alterations that affect the regulation and function of genes. These pathologic changes are selected during progression to yield cells that multiply aggressively beyond the limits normally set by their intrinsic proliferative capacity, neighboring cells, limited mitogens, and blood supply. It is expected that the cataloging of specific changes in gene expression will provide diagnostic markers for any given type. Furthermore, proteins encoded by specific genes could potentially serve as targets for therapeutic intervention. 2)In addition to the therapeutic strategies already known, some recent reports indicate new areas for the development of target selective drugs for the treatment of metastatic breast cancer.3) The earliest adjuvant chemotherapy, with singleagent alkylating and anti-metabolic drugs, was soon replaced by combination therapy, as it was demonstrated that simultaneous combination of two or more agents provided better results. 4,5) Kalpaamruthaa is a Siddha formulation, which has been formulated in our laboratory. They contain Semecarpus anacardium LINN. (SA), Emblica officinalis and honey with different ratio. Kalpaamruthaa (KA) is a Siddha preparation which has been formulated in our laboratory, the components studies of this drug reveals the presence of flavonoids, ascorbic acid, polyphenols, tannins, sugars and sterols. Flavonoids are seemingly more widely dispersed in the food supply and are of more varied composition than are isoflavones. For these reason, their absorption and metabolism have been less completely characterized. Cameron and Pauling 6) believed that ascorbic acid combats cancer by promoting collagen synthesis and thus prevents tumors from invading other tissues. Flavonoids are polyphenols widely distributed and known to possess biological and pharmacological activities, including anti-inflammatory action against free radicals. 7)Isoflavonoids are members of the broad class of plant polyphenols that have been shown in vivo to have benefit in the treatment of a wide variety of chronic diseases, including cancer. Another important consideration in vivo is the localized metabolism of isoflavones that may occur in the vicinity of tumor cells. Many experiments to verify the association between isoflavone intake and disease prevention have been reported. 8)The biochemical evaluation of glycoprotein components, marker enzymes and lysosomal enzymes of liver, kidney and blood of control and experimental rats was carried out to study the therapeutic efficacy of KA on 7,12-dimethylbenz-(a)anthracene (DMBA) induced mammary carcinoma bearing rats (Sprague-Dawley strain). This study was undertaken to arrive at the effective dose of KA in mammary carcinoma condition in rats. MATERIALS AND METHODS MaterialsMammary carcinoma was induced ...

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Single and combination nonhormonal chemotherapy in breast cancer

Cited by 138 publications

References 25 publications

Chemotherapy of advanced breast cancer: a controlled randomized trial of cyclophosphamide versus a four-drug combination

Chemotherapy of advanced breast cancer: a controlled randomized trial of cyclophosphamide versus a four-drug combination

Low LATS2 mRNA level can predict favorable response to epirubicin plus cyclophosphamide, but not to docetaxel, in breast cancers

Anticancer Effect of Kalpaamruthaa on Mammary Carcinoma in Rats with Reference to Glycoprotein Components, Lysosomal and Marker Enzymes

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