Single dose pharmacokinetic study of flofenicol in tilapia (Oreochromis niloticus×O. aureus) held in freshwater at 22 °C

Feng, Jingbin; Jia, Xiaoping

doi:10.1016/j.aquaculture.2008.12.023

Cited by 53 publications

(52 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These values therefore show that, following recommended medication with florfenicol (10 mg kg −1 daily for 10 consecutive days), the mean concentrations in plasma will exceed the MIC value of 0.5 µg ml −1 by a good margin for the entire medication period and have the potential of providing a therapeutic effect (Samuelsen et al 2003b). In comparison, a single dose of 10 mg kg −1 florfenicol to tilapia (Oreochromis niloticus × O. aureus) gave C max concentrations of 4.46 µg ml −1 in plasma, 6.88 µg g −1 in muscle and 5.87 µg g −1 in liver and faster elimination with t 1/2 β values of 10 h in plasma, 11 h in muscle and 14 h in liver (Feng & Jia 2009), which is considerably lower than the values found in cod. However, according to Bowser et al (2009) resulted in plasma and tissue concentrations in tilapia similar to or higher than those found in cod by Samuelsen & Bergh (2004).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial susceptibility of Francisella noatunensis subsp. noatunensis strains isolated from Atlantic cod Gadus morhua in Norway

Isachsen

Vågnes²,

Jakobsen³

et al. 2012

Dis. Aquat. Org.

View full text Add to dashboard Cite

A total of 30 isolates of Francisella noatunensis subsp. noatunensis isolated from Atlantic cod Gadus morhua L. were tested for susceptibility, in the form of minimal inhibitory concentration (MIC) values, against the following antibacterial agents: flumequine, oxolinic acid, ciprofloxacin, florfenicol, oxytetracycline, erythromycin, streptomycin sulphate, trimetoprim/ sulphadiazine and rifampin. All the isolates had a low susceptibility to oxytetracycline, trimetoprim/sulphadiazine (Tribrissen ® ), erythromycin, ciprofloxacin and streptomycin with MIC values of 64, 64 to 128, 16, 8 and 32 to 128 µg ml Dis Aquat Org 98: [57][58][59][60][61][62] 2012 markedly more active against oxolinic-acid-resistant isolates of Aeromonas salmonicida (Lewin & Hastings 1990). F. noatunensis subsp. noatunensis is a slowgrowing bacterium, and rifampin, erythromycin and streptomycin sulphate are all antibacterial agents that are used in human medicine in the treatment of Mycobacterium tuberculosis, another slow-growing bacterium. Erythromycin is also occasionally used against bacterial kidney disease (BKD) in salmonids.The aim of the present study was to test the susceptibility, in the form of MIC values, to a number of isolates of Francisella noatunensis subsp. noatunensis against the selected group of antibacterial agents. MATERIALS AND METHODS Bacterial strainsA total of 30 isolates of Francisella noatunensis subsp. noatunensis from Atlantic cod Gadus morhua L. were analysed. Of these, 28 isolates were provided by the Norwegian Veterinary Institute (Norway) and 2 isolates, GM2212/LMG 24256 (Nylund et al. 2006, Ottem et al. 2007) and EK-4b, were provided by the Institute of Marine Research (Norway). All isolates originate from farmed cod, except EK-4b, which was isolated from a wild cod. The strains were previously identified as F. noatunensis subsp. noatunensis using the methods described by Ottem et al. (2008). ChemicalsFlumequine, oxolinic acid, oxytetracycline, florfenicol, Tribrissen (trimethoprim/sulfadiazine), erythromycin, ciprofloxacin, streptomycin sulphate and rifampin were all obtained from Norwegian Medical Depot (Bergen, Norway). Stock solutions of antibacterial agents were prepared at a concentration of 1.0 mg ml −1 in methanol (florfenicol, Tribrissen, rifampin), in water (oxytetracycline, erythromycin, streptomycin sulphate), 0.03 M NaOH (flumequine, oxolic acid) and 0.03 M NaOH/methanol (1:1) (ciprofloxacin). MIC determinationIn order to meet the demands of Francisella noatunensis subsp. noatunensis for specific growth factors, the method of choice in the present work was a modified agar dilution test for the determinations of MIC values (Alderman & Smith 2001). Briefly, F. noatunensis subsp. noatunensis isolates were grown on modified Mueller-Hinton agar (MMHA) supplemented with 3% foetal bovine serum (FBS) (PAA Laboratories), 0.8% glucose (Merck), 0.4% L-cystein (Sigma) and 4% Yeastolate Ultrafiltrate (Gibco) and containing 2-fold dilutions of the antibacterial agents tested. All supplements and a...

show abstract

Section: Discussionmentioning

confidence: 99%

Antimicrobial susceptibility of Francisella noatunensis subsp. noatunensis strains isolated from Atlantic cod Gadus morhua in Norway

Isachsen

Vågnes²,

Jakobsen³

et al. 2012

Dis. Aquat. Org.

View full text Add to dashboard Cite

show abstract

“…, 2003), red pacu (Lewbart et al. , 2005), and tilapia (Feng & Jia, 2009). However, its pharmacokinetic properties were not investigated in olive flounder (bastard halibut), Paralichthys olivaceus , although olive flounder is one of the most important cultured fish species in coastal areas of Korea, Japan, and China.…”

Section: Pharmacokinetic Parameters Of Florfenicol Following Intravementioning

confidence: 99%

Pharmacokinetics of florfenicol following intramuscular and intravenous administration in olive flounder (Paralichthys olivaceus)

Lim

Kim

Hwang

et al. 2010

Vet Pharm & Therapeutics

View full text Add to dashboard Cite

“…Florfenicol, the latest generation of amphenicols, has been specifically developed for veterinary use. Florfenicol has been approved for use in export eel in China (Feng & Jia ), in catfish and freshwater‐reared salmonids in USA (Carty et al . ) and in Norwegian aquaculture (Samuelsen, Bergh & Ervik ).…”

Section: Introductionmentioning

confidence: 99%

“…), Korean catfish (Park et al . ), tilapia (Feng & Jia ), olive flounder (Lim et al . ), crucian carp (Zhao et al .…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of florfenicol and behaviour of its metabolite florfenicol amine in orange‐spotted grouper (Epinephelus coioides) after oral administration

Dr²,

Zhong

et al. 2015

Journal of Fish Diseases

View full text Add to dashboard Cite

Pharmacokinetics and elimination of florfenicol and florfenicol amine in grouper held in sea water at 23.3 AE 0.8°C were studied using HPLC method after they were given a single peroral dose of florfenicol at 24 mg kg À1 body weight. Florfenicol was rapidly absorbed from intestine and distributed extensively to all the tissues examined. The maximum concentrations (C max , lg g À1 or lg mL À1 ) in plasma and tissues were observed at 2-6 h (the time to reach maximum concentration, T max ) except for bile (T max = 24 h) and were in the order of intestine (52.02 AE 25.07) > bile (49.41 AE 28.16) > gill (45.12 AE 11.10) > plasma (28.28 AE 5.43) > liver (21.97 AE 12.08) > muscle (21.63 AE 6.12) > kidney (20.88 AE 11.28) > skin (19.10 AE 5.88). The drug distribution level was higher in plasma than in extravascular tissues except for bile, based on the ratios of the area under concentration-time curve between tissue and plasma (AUC tissue/plasma ). The elimination of florfenicol was rapid in fish, and the corresponding half-lives (T 1/2b ) in the order of magnitude were bile (13.92 h) > muscle or liver (12.31 h) > skin (11.77 h) > plasma (11.57) > gill (11.04 h) > intestine (10.55 h) > kidney (10.05 h). The delayed T max , lower C max and longer T 1/2b for florfenicol amine compared with florfenicol were measured in grouper.

show abstract

Single dose pharmacokinetic study of flofenicol in tilapia (Oreochromis niloticus×O. aureus) held in freshwater at 22 °C

Cited by 53 publications

References 22 publications

Antimicrobial susceptibility of Francisella noatunensis subsp. noatunensis strains isolated from Atlantic cod Gadus morhua in Norway

Antimicrobial susceptibility of Francisella noatunensis subsp. noatunensis strains isolated from Atlantic cod Gadus morhua in Norway

Pharmacokinetics of florfenicol following intramuscular and intravenous administration in olive flounder (Paralichthys olivaceus)

Pharmacokinetics of florfenicol and behaviour of its metabolite florfenicol amine in orange‐spotted grouper (Epinephelus coioides) after oral administration

Contact Info

Product

Resources

About