Sister chromatid exchanges and micronuclei analysis in lymphocytes of men exposed to simazine through drinking water

Suárez, Sonia; Rubio, Arantxa; Sueiro, Rosa Ana; Garrido, Joaquı́n

doi:10.1016/s1383-5718(03)00080-9

Cited by 10 publications

(6 citation statements)

References 32 publications

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“…They also determined an increased rate of SCE in alcohol consuming and cigarette smoking people. An increased rate of SCE frequency was also reported in some people drinking water which contained toxic agents such as arsenic or simazine 31,32 . There are some reports of increased SCE values during psoralen plus ultraviolet A (PUVA) treatment of patients with psoriasis vulgaris.…”

Section: Discussionmentioning

confidence: 98%

“…DNA damage and repair mechanism defects may play an important role in SCE mechanisms. Behavioral stress, some drugs, dietary habits, smoking, occupational exposure and some chemical agents have been demonstrated to increase SCE frequency 13–16,27–32 . In some reports, the SCE rate was found to be higher in cigarette smokers than in non‐smokers 28–30 .…”

Section: Discussionmentioning

confidence: 99%

“…Behavioral stress, some drugs, dietary habits, smoking, occupational exposure and some chemical agents have been demonstrated to increase SCE frequency. [13][14][15][16][27][28][29][30][31][32] In some reports, the SCE rate was found to be higher in cigarette smokers than in non-smokers. 28 -30 They also determined an increased rate of SCE in alcohol consuming and cigarette smoking people.…”

Section: Discussionmentioning

confidence: 99%

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Chromosome and sister chromatid exchange studies in Behcet's patients

Öztaş

Güllülü

Tatar

et al. 2006

The Journal of Dermatology

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Behcet's disease is a chronic multisystemic disease of unknown pathogenesis characterized by four major symptoms: oral aphthous ulcers, skin lesions, ocular symptoms and genital ulcerations. The disease is spread throughout the world, but it is most frequent in Turkey, Japan, Korea and China. Although HLA-Bw51 has been found to predominate in Behcet's cases, the genetic etiology has not yet been clarified. In this study, we investigated the chromosomal abnormalities and sister chromatid exchange rates in patients with Behcet's diseases. Thirty-eight patients with Behcet's disease (diagnosed for the first time) and 30 healthy subjects (as controls) were included in this study. Although numerical and structural chromosomal abnormalities were not detected in our patients, we found an increased rate of sister chromatid exchange in patients over the control groups (P < 0.01). On the basis of these results, we discuss the genetic etiology of Behcet's disease.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Chromosome and sister chromatid exchange studies in Behcet's patients

Öztaş

Güllülü

Tatar

et al. 2006

The Journal of Dermatology

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“…We conducted the sensitivity analysis and found that the study including Bauchinger et al (1982), Carbonell et al (1993), Costa et al (2006), Gomez-Arroyo et al (1992), Hoyos et al (1996), Joksic et al (1997), Kourakis et al (1996), Lander et al (1995), Linnaimaa (1983), Pasquini et al (1996), Scarpato et al (1996), Steenland et al (1997) and Suarez et al (2003) was homogenous for SCE among total population, and the Q value for test of heterogeneity was 18.67 (df=12, p=0.097) (Figure 3). …”

Section: Sensitivity Analysismentioning

confidence: 99%

“…Sister chromatid exchange (SCE) in human peripheral blood lymphocytes is one of the most extensively studied biomarkers of cytogenetic damage. However, the results from epidemiological studies remained inconsistent and controversial (Bauchinger et al, 1982;Linnainmaa, 1983;Rupa et al, 1988;Jablonicka et al, 1989;De Ferrari et al, 1991;Rupa et al, 1991;Gomez-Arroyo et al, 1992;Carbonell et al, 1993;Lander et al, 1995;Hoyos et al, 1996;Kourakis et al, 1996;Pasquini et al, 1996;Scarpato et al, 1996;Joksic et al, 1997;Steenland et al, 1997;Gomez-Arroyo et al, 2000;Hatjian et al, 2000;Padmavathi et al, 2000;Shaham et al, 2001;Zeljezic et al, 2002;Suarez et al, 2003;Costa et al, 2006;Ergene et al, 2007;Rowland et al, 2007;Martinez-Valenzuela et al, 2009). In order to obtain a precise estimate of the association of SCE frequency with pesticide exposure, we collected published data to evaluate the validation of SCE in human peripheral blood lymphocytes as a cytogenetic biomarker of pesticideexposed population.…”

Section: Introductionmentioning

confidence: 99%

Increased Sister Chromatid Exchange in Peripheral Blood Lymphocytes from Humans Exposed to Pesticide: Evidence Based on a Meta-analysis

Yang¹,

Liu²,

Yang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Sister chromatid exchange (SCE) in human peripheral blood lymphocytes is one of the most extensively studied biomarkers employed to evaluate genetic damage subsequent to pesticide exposure. Objective: To estimate the pooled levels of SCE in human peripheral blood lymphocytes among population exposed to pesticide. Materials and Methods: Meta-analysis on the association between SCE frequency and pesticide exposure was performed with STATA 10.0 software package and Review Manager 5.0.24 in this study. Results: The overall means of SCE were 7.88 [95% confidence intervals (95%CI): 6.71-9.04] for exposure group and 6.05 (95%CI: 5.13-6.95) for controls, respectively. There was statistically significant difference in the SCE frequency in human peripheral blood lymphocytes between pesticide-exposed groups and control groups, and the summary estimate of weighted mean difference was 1.69 (95%CI: 1.01-2.38). We also observed that pesticide-exposed population had significantly higher SCE frequency than control groups among smokers, nonsmokers, pesticide applicator, pesticide producer, other exposure population and Asian population in stratified analyses. Conclusions: Data indicate that the SCE frequency in human peripheral blood lymphocytes might be an indicator of early genetic effects for pesticide-exposed populations. s Keywords: Sister chromatid exchange -pesticide -peripheral blood lymphocytes -meta-analysis

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Alkylpyridines and Miscellaneous Organic Nitrogen Compounds

Peterson

2023

Patty's Toxicology

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This chapter provides a broad overview of topics related to the occupational use and exposure to a variety of miscellaneous nitrogen‐containing compounds. Topics addressed include chemical/physical properties, uses, exposure assessment, and toxic effects, as well as standards, regulations, and guidelines for exposure. Some of the chemicals and classes represented in this chapter include pyridine, alkylpyridines, vinylpyridines, aminopyridines, aminopicolines, pyridinethione compounds (pyrithiones), nicotine, the substituted uracils, quaternary herbicides, s ‐triazine herbicides, propazine, cyanazine, ametryn, prometryn, simazine, hexazinone, azides, and hydrazine and its derivatives.

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Sister chromatid exchanges and micronuclei analysis in lymphocytes of men exposed to simazine through drinking water

Cited by 10 publications

References 32 publications

Chromosome and sister chromatid exchange studies in Behcet's patients

Chromosome and sister chromatid exchange studies in Behcet's patients

Increased Sister Chromatid Exchange in Peripheral Blood Lymphocytes from Humans Exposed to Pesticide: Evidence Based on a Meta-analysis

Alkylpyridines and Miscellaneous Organic Nitrogen Compounds

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