Six Weeks of Fluoroquinolone Antibiotic Therapy for Patients With Elevated Serum Prostate-specific Antigen Is Not Clinically Beneficial: A Randomized Controlled Clinical Trial

The Relationship Between Prostate Biopsy Results and PSA and Free PSA Ratio Changes in Elevated Serum PSA Patients with and without Antibiotherapy

“…If pathological results of treatment and control groups would be evaluated in terms of PSA changes; although Sarıbacak et al, (2014) reported that the PSA decrease in the group receiving antibiotics and with pathology results reported as BPH was found statistically significant as compared to the control group, similarly to many other studies in literature, there was no significant relationship between pathological results and PSA changes while taking the cut off values 5% and %10 in this study (Shtricker et al, 2009;Stopiglia et al, 2010;Heldwein et al, 2011;Eggener et al, 2013;Toktas et al, 2013;Fandella et al, 2014;Greiman et al, 2016).…”

“…In literature, there are some studies that significant decreases in PSA were observed following the antibiotherapy (Guercio et al, 2004;Kyung et al, 2010;Tang et al, 2010;Torky et al, 2011). In contrast, there are also studies reporting no significant PSA decreases Beside the studies reporting that there are no significant differences between the control PSA levels of cases who had received antibiotic therapy and the control PSA levels left to the natural course as reported in this study (Shtricker et al, 2009;Stopiglia et al, 2010;Heldwein et al, 2011;Eggener et al, 2013;Toktas et al, 2013;Fandella et al, 2014;Yang et al, 2015;Greiman et al, 2016), there are also contradicting studies (Erol et al, 2006;Saribacak et al, 2014;Topac et al, 2016).…”

Oral administration of cernitin pollen extract (Cernilton®) for 30 days might be useful to avoid unnecessary biopsy in prostate biopsy candidates: A preliminary study

“…[18][19][20] Also, several studies have reported that an unnecessary prostate biopsy procedure can be avoided when a decline in serum PSA level is observed after administration of fluoroquinolone for 2-4 weeks in candidates for the procedure. [21][22][23] Furthermore, quinolone-resistant Escherichia coli bacterial infection induced by a long-term administration of fluoroquinolone has been reported to be a risk factor for sepsis after a prostate biopsy, indicating that antimicrobials should not be routinely administered to candidates for that procedure. [21][22][23] Furthermore, quinolone-resistant Escherichia coli bacterial infection induced by a long-term administration of fluoroquinolone has been reported to be a risk factor for sepsis after a prostate biopsy, indicating that antimicrobials should not be routinely administered to candidates for that procedure.…”

“…[4][5][6][7] In contrast, others found no such effect from antimicrobial administration in their patients with a PSA level considered to be in the so-called gray zone. [21][22][23] Furthermore, quinolone-resistant Escherichia coli bacterial infection induced by a long-term administration of fluoroquinolone has been reported to be a risk factor for sepsis after a prostate biopsy, indicating that antimicrobials should not be routinely administered to candidates for that procedure. 24,25 Cernitin pollen extract is considered to be therapeutically effective for chronic prostatitis.…”

“…4,6,7,21 Furthermore, the mean change in serum PSA level from the baseline for all of our patients was À0.6 AE 1.4 ng/mL, with similar findings (À0.68 to À2.97 ng/mL) reported after antimicrobial administration. 5,7,21,23 All patients (n = 78) Subjects analyzed (n = 61)…”