Sleep Disorders in Fibromyalgia Syndrome

Rizzi, Maurizio; Cristiano, Andrea; Frassanito, Francesca; Macaluso, Claudio; Airoldi, Andrea; Sarzi‐Puttini, Piercarlo

doi:10.4172/2167-0846.1000232

Cited by 5 publications

(4 citation statements)

References 57 publications

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“…The results obtained with this study presents evidence that the reduction of pain can lead to improvements in sleep quality, as well as the reduction of latency to start sleep and the time spent awake throughout the night. These data are in line with other studies that point to the impact of pain on the sleep macrostructure (Finan, 2018;Keskindag & Karaaziz, 2017;Rizzi et al, 2016;Roizenblatt et al, 2001). The actigraph did not record the data in 31% of the evaluations, and the participants did not correctly use the actigraph in 12%, totalizing 47% of the lost records.…”

Section: Discussionsupporting

confidence: 92%

“…The literature indicates an important correlation between intensity and inability of pain and changes in the macro and microstructure of sleep in people with FM (Bennett, Clark, Campbell, & Burckhardt, 1992;Keskindag & Karaaziz, 2017;Rizzi et al, 2016;Roizenblatt, Moldofsky, Benedito-Silva, & Tufik, 2001). Bennett et al (1992) observed that there was an increase in pain, fatigue, and pro-inflammatory cytokines in female patients with FM who had slow-wave sleep deprivation.…”

Section: Introductionmentioning

confidence: 99%

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Behavior-analytic intervention for women with fibromyalgia and insomnia: a single subject design

Kirchner

Reis

2021

Psicol. Refl. Crít.

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This study evaluated the effects in the pain and sleep, and the clinic significance after an analytic-behavioral intervention to manage the condition of the physical and interpersonal environment related to pain. Four women with fibromyalgia and insomnia participated in a study with intervention withdrawal multiple baseline design and initial, intermediate, final, and follow-up assessments. Self-report instruments were used to assess pain intensity and disability, sleep quality, and insomnia severity, besides the actigraphy. Data showed that the intervention (20 sessions) was effective in reducing the sleep and pain problems in all participants by shifting two participants from clinical to non-clinical status in sleep indicators. The gains were maintained or increased in follow-up measures. However, the results should take into consideration the clinical condition and other variables that may have individually impacted the results.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Behavior-analytic intervention for women with fibromyalgia and insomnia: a single subject design

Kirchner

Reis

2021

Psicol. Refl. Crít.

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“…Following the reserpine administration period, a clear switch in the EEG pattern and the sleep architecture took place. Briefly, the main changes included diminished REM sleep, which is a polysomnographic characteristic in FMS (Rizzi & Cristiano, ), together with abnormally long periods of NREM sleep. The increased muscular tone and muscle twitches still remained.…”

Section: Discussionmentioning

confidence: 99%

Hippocampal oscillatory dynamics and sleep atonia are altered in an animal model of fibromyalgia: Implications in the search for biomarkers

Blasco‐Serra

Alfosea‐Cuadrado

Cervera‐Ferri

et al. 2019

J of Comparative Neurology

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The pathogenesis of fibromyalgia is still unknown. Core symptoms include pain, depression, and sleep disturbances with high comorbidity, suggesting alterations in the monoaminergic system as a common origin of this disease. The reserpine‐induced myalgia (RIM) model lowers pain thresholds and produces depressive‐like symptoms. The present work aims to evaluate temporal dynamics in the oscillatory profiles and motor activity during sleep in this model and to evaluate if the model mimics the sleep disorders that occur in fibromyalgia patients. Hippocampal and electromyogram activity were recorded in chronically implanted rats. Following 3 days of basal recordings, reserpine was administered on three consecutive days to achieve the RIM. Postreserpine recordings were taken on alternate days for 21 days. Reserpine induced changes in the sleep architecture with more transitions between states, and a different pattern between the administration period and postreserpine weeks. Administration days were characterized by a larger amount of rapid eyes movement sleep with dominant theta waves without atonia. Following the reserpinization, theta oscillations were always more fragmented and with lower frequency. On the postreserpine days, sleep was dominated by slow‐wave sleep with fast intrusions and reduced hierarchical coupling with spindles and ripples. Simultaneous electromyography recordings also showed muscle twitches during sleep and the dissociation of theta activity and muscle atonia. Abnormally high slow waves, alpha/delta intrusions, frequent transitions, and muscle twitches are common traits in fibromyalgia. Therefore, our analyses support the validity of the RIM model to study sleep disorders in fibromyalgia, and provide new insights into the research of oscillographic biomarkers.

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“…Poor sleep quality is a prominent symptom, and the main sleep problems described for this condition include reduced sleep efficiency, long wake times after sleep onset, a decrease in the percentage of deep sleep, and an increased percentage of light sleep (Andrade et al, 2018; Lawson, 2020; Rizzi & Cristiano, 2016; Roth et al, 2016; Wu et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Sleeping is a nightmare: A qualitative study on the experience and management of poor sleep quality in women with fibromyalgia

Climent‐Sanz

Gea-Sánchez

Fernández‐Lago

et al. 2021

Journal of Advanced Nursing

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Sleep Disorders in Fibromyalgia Syndrome

Cited by 5 publications

References 57 publications

Behavior-analytic intervention for women with fibromyalgia and insomnia: a single subject design

Behavior-analytic intervention for women with fibromyalgia and insomnia: a single subject design

Hippocampal oscillatory dynamics and sleep atonia are altered in an animal model of fibromyalgia: Implications in the search for biomarkers

Sleeping is a nightmare: A qualitative study on the experience and management of poor sleep quality in women with fibromyalgia

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