SNR-Adaptive OCT Angiography Enabled by Statistical Characterization of Intensity and Decorrelation With Multi-Variate Time Series Model

Huang, Luzhe; Fu, Yiming; Chen, Ruixiang; Yang, Shanshan; Qiu, Haixia; Wu, Xining; Zhao, Shiyong; Gu, Ying; Li, Peng

doi:10.1109/tmi.2019.2910871

Cited by 33 publications

(24 citation statements)

References 38 publications

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“…These signals are observed in the inner choroidal layers in healthy eyes, and they may change in the lesions from a variety of chorioretinal diseases. 14 , 15 In the two cases described herein, the decorrelation signals were not observed inside the MCM. We raise two conjectures for the absence of decorrelation signals inside the abnormal choroidal vessel.…”

Section: Discussionmentioning

confidence: 68%

En-face OCT and OCT angiography analysis of macular choroidal macrovessel

Neto¹,

Lima

Zett

et al. 2021

American Journal of Ophthalmology Case Reports

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Section: Discussionmentioning

confidence: 68%

En-face OCT and OCT angiography analysis of macular choroidal macrovessel

Neto¹,

Lima

Zett

et al. 2021

American Journal of Ophthalmology Case Reports

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“…OCTA is the functional extension of OCT to obtain blood vessels map without contrast agents. [70][71][72] Because our electrode is transparent, OCTA image showed the vessels beneath the electrode without any obstruction (Figure 5b). The region of interest for detecting the relative change in deoxy-Hb in blood vessels was selected near the microelectrode (Figure S26, Supporting Information).…”

Section: Resultsmentioning

confidence: 97%

A Stretchable and Transparent Electrode Based on PEGylated Silk Fibroin for In Vivo Dual‐Modal Neural‐Vascular Activity Probing

Cui

Zhang²,

Chen

et al. 2021

Advanced Materials

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Transparent electrodes that form seamless contact and enable optical interrogation at the electrode–brain interface are potentially of high significance for neuroscience studies. Silk hydrogels can offer an ideal platform for transparent neural interfaces owing to their superior biocompatibility. However, conventional silk hydrogels are too weak and have difficulties integrating with highly conductive and stretchable electronics. Here, a transparent and stretchable hydrogel electrode based on poly(3,4‐ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) and PEGylated silk protein is reported. PEGylated silk protein with poly(ethylene glycol) diglycidyl ether (PEGDE) improves the Young's modulus to 1.51–10.73 MPa and the stretchability to ≈400% from conventional silk hydrogels (<10 kPa). The PEGylated silk also helps form a robust interface with PEDOT:PSS thin film, making the hydrogel electrode synergistically incorporate superior stretchability (≈260%), stable electrical performance (≈4 months), and a low sheet resistance (≈160 ± 56 Ω sq−1). Finally, the electrode facilitates efficient electrical recording, and stimulation with unobstructed optical interrogation and rat‐brain imaging are demonstrated. The highly transparent and stretchable hydrogel electrode offers a practical tool for neuroscience and paves the way for a harmonized tissue–electrode interface.

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“…2(a) and 2(b) to emphasize blood flow by mathematically analyzing the temporal dynamics induced by moving red blood cells (RBCs). 49 The cross-sectional angiogram was binarized to generate an avascular mask for each frame in one trial, where the vessel area was set to be zero and the surrounding tissue was one. The intersection of all single-frame avascular masks was taken as the final vascular mask, as showed in Fig.…”

Section: Discussionmentioning

confidence: 99%

“…To see the hemodynamic response to INS, the RBCs-induced interframe decorrelation value of OCTA was used as the velocity index of blood flow. 49 OISI and OCT were spatially coregistered using pial blood vessels as rough landmarks and shifting the ROI until Pearson's correlation coefficient of OISI image (540-nm green LED illumination) and projection view of OCT reached the maximum. Accordingly, the functional OISI signals were calculated in a similar way yet without masks.…”

Section: Discussionmentioning

confidence: 99%

INS-fOCT: a label-free, all-optical method for simultaneously manipulating and mapping brain function

et al. 2020

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Significance: Current approaches to stimulating and recording from the brain have combined electrical or optogenetic stimulation with recording approaches, such as two-photon, electrophysiology (EP), and optical intrinsic signal imaging (OISI). However, we lack a label-free, all-optical approach with high spatial and temporal resolution. Aim: To develop a label-free, all-optical method that simultaneously manipulates and images brain function using pulsed near-infrared light (INS) and functional optical coherence tomography (fOCT), respectively. Approach: We built a coregistered INS, fOCT, and OISI system. OISI and EP recordings were employed to validate the fOCT signals. Results: The fOCT signal was reliable and regional, and the area of fOCT signal corresponded with the INS-activated region. The fOCT signal was in synchrony with the INS onset time with a delay of ∼30 ms. The magnitude of fOCT signal exhibited a linear correlation with the INS radiant exposure. The significant correlation between the fOCT signal and INS was further supported by OISI and EP recordings. Conclusions: The proposed fiber-based, all-optical INS-fOCT method allows simultaneous stimulation and mapping without the risk of interchannel cross-talk and the requirement of contrast injection and viral transfection and offers a deep penetration depth and high resolution.

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SNR-Adaptive OCT Angiography Enabled by Statistical Characterization of Intensity and Decorrelation With Multi-Variate Time Series Model

Cited by 33 publications

References 38 publications

En-face OCT and OCT angiography analysis of macular choroidal macrovessel

En-face OCT and OCT angiography analysis of macular choroidal macrovessel

A Stretchable and Transparent Electrode Based on PEGylated Silk Fibroin for In Vivo Dual‐Modal Neural‐Vascular Activity Probing

INS-fOCT: a label-free, all-optical method for simultaneously manipulating and mapping brain function

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