Sodium Butyrate Downregulates Implant-Induced Inflammation in Mice

Lazari, Marcela Guimarães Takahashi de; Pereira, Luciana Xavier; Orellano, Laura Alejandra Ariza; Scheuermann, Karina; Machado, Clara Tolentino; Vasconcelos, A.C.; Andrade, Sílvia Passos; Campos, Paula Peixoto

doi:10.1007/s10753-020-01205-0

Cited by 12 publications

(24 citation statements)

References 29 publications

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“…The results showed that after administration of sodium butyrate, indicators such as heart size were relieved. The expression level of TGF-β was decreased after butyrate administration, consistent with the results of some previous articles ( 49 – 52 ). However, some articles have suggested that butyrate has a synergistic effect with TGF-β and that butyrate administration increases the level of TGF-β expression ( 53 – 55 ).…”

Section: Discussionsupporting

confidence: 92%

Clostridium butyricum and Bifidobacterium pseudolongum Attenuate the Development of Cardiac Fibrosis in Mice

Wang

Chen

et al. 2022

Microbiol Spectr

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Section: Discussionsupporting

confidence: 92%

Clostridium butyricum and Bifidobacterium pseudolongum Attenuate the Development of Cardiac Fibrosis in Mice

Wang

Chen

et al. 2022

Microbiol Spectr

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“…The data presented here demonstrate that oral administration of NaBu (100 mg/kg), a synthetic form of short-chain fatty acid, attenuated the inflammatory, angiogenic and fibrogenic components of in inflammatory sites and processes, including those in the sponge implant (Araújo et al, 2011;de Lazari et al, 2020;Marques et al, 2014;Mendes et al, 2007Mendes et al, , 2009. Myeloperoxidase activity, for example, was used as an inflammatory parameter to evaluate the effects of butyrate in a rat colitis model (Butzner et al, 1996;Simeoli et al, 2017).…”

Section: Discussionmentioning

confidence: 80%

Sodium butyrate attenuates peritoneal fibroproliferative process in mice

Lazari

Viana

Pereira

et al. 2022

Experimental Physiology

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The aim of this study was to identify the bio-efficacy of sodium butyrate (NaBu) on preventing the development of peritoneal fibrovascular tissue induced by implantation of a synthetic matrix in the abdominal cavity.Polyether-polyurethane sponge discs were implanted in the peritoneal cavity of mice, which were treated daily with oral administration of NaBu (100 mg/kg). Control animals received water (100 μl). After 7 days, the implants were removed for assessment of inflammatory, angiogenic and fibrogenic markers.Compared with control values, NaBu treatment decreased mast cell recruitment/ activation, inflammatory enzyme activities, levels of pro-inflammatory cytokines, and the proteins p65 and p50 of the nuclear factor-κB pathway. Angiogenesis, as determined by haemoglobin content, vascular endothelial growth factor levels and the number of blood vessels in the implant, was reduced by the treatment. In NaButreated animals, the predominant collagen present in the abdominal fibrovascular tissue was thin collagen, whereas in control implants it was thick collagen. Transforming growth factor-β1 levels were also lower in implants of treated animals.Sodium butyrate downregulated the inflammatory, angiogenesis and fibrogenesis axes of the fibroproliferative tissue induced by the intraperitoneal synthetic matrix. This compound has potential to control/regulate chronic inflammation and adverse healing processes in the abdominal cavity.

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“…Butyrate inhibits dimer formation by down-regulating p65 and by preventing its movement into the nucleus. As such, it interferes with the action of NF-κB, which also improves the stability of atherosclerotic plaque ( 115 – 117 ). When consumed orally, butyrate decreases the level of oxLDL in obese patients and decreases the inflammatory response of circulating monocytes ( 118 ).…”

Section: Discussionmentioning

confidence: 99%

Global research trends in atherosclerosis: A bibliometric and visualized study

Tian

Zhang

Wang

et al. 2022

Front. Cardiovasc. Med.

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BackgroundIncreasing evidence has spurred a considerable evolution of concepts related to atherosclerosis, prompting the need to provide a comprehensive view of the growing literature. By retrieving publications in the Web of Science Core Collection (WoSCC) of Clarivate Analytics, we conducted a bibliometric analysis of the scientific literature on atherosclerosis to describe the research landscape.MethodsA search was conducted of the WoSCC for articles and reviews serving exclusively as a source of information on atherosclerosis published between 2012 and 2022. Microsoft Excel 2019 was used to chart the annual productivity of research relevant to atherosclerosis. Through CiteSpace and VOSviewer, the most prolific countries or regions, authors, journals, and resource-, intellectual-, and knowledge-sharing in atherosclerosis research, as well as co-citation analysis of references and keywords, were analyzed.ResultsA total of 20,014 publications were retrieved. In terms of publications, the United States remains the most productive country (6,390, 31,93%). The most publications have been contributed by Johns Hopkins Univ (730, 3.65%). ALVARO ALONSO produced the most published works (171, 0.85%). With a betweenness centrality of 0.17, ERIN D MICHOS was the most influential author. The most prolific journal was identified as Atherosclerosis (893, 4.46%). Circulation received the most co-citations (14,939, 2.79%). Keywords with the ongoing strong citation bursts were “nucleotide-binding oligomerization (NOD), Leucine-rich repeat (LRR)-containing protein (NLRP3) inflammasome,” “short-chain fatty acids (SCFAs),” “exosome,” and “homeostasis,” etc.ConclusionThe research on atherosclerosis is driven mostly by North America and Europe. Intensive research has focused on the link between inflammation and atherosclerosis, as well as its complications. Specifically, the NLRP3 inflammasome, interleukin-1β, gut microbiota and SCFAs, exosome, long non-coding RNAs, autophagy, and cellular senescence were described to be hot issues in the field.

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Sodium Butyrate Downregulates Implant-Induced Inflammation in Mice

Cited by 12 publications

References 29 publications

Clostridium butyricum and Bifidobacterium pseudolongum Attenuate the Development of Cardiac Fibrosis in Mice

Clostridium butyricum and Bifidobacterium pseudolongum Attenuate the Development of Cardiac Fibrosis in Mice

Sodium butyrate attenuates peritoneal fibroproliferative process in mice

Global research trends in atherosclerosis: A bibliometric and visualized study

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