Sodium Dodecyl Sulfate-assisted Synthesis of 1-(Benzothiazolylamino)methyl-2-naphthols in Water

Abstract

An efficient synthesis of 1‐(benzothiazolylamino)methyl‐2‐naphthols has been developed in water by one‐pot condensation of 2‐naphthol, aldehydes and 2‐aminobenzothiazole catalyzed by sodium dodecyl sulfate. Advantages of the methodology include a very short reaction time, excellent yields and catalytic use of the sodium dodecyl sulfate.

3-Substitued indoles: One-pot synthesis and evaluation of anticancer and Src kinase inhibitory activities

“…20 A number of small molecule inhibitors 21−22 have shown potential biological activity as both antiproliferative and anti-invasive agents in preclinical studies in different solid tumor types. 23−26 In continuation of our efforts towards the development of organic transformations catalyzed by metal triflates 27 and synthesis of small molecules as anticancer agents and/or c-Src kinase inhibitors, 15,28 herein we report an expeditious one-pot synthesis of 3substituted indoles by three component condensation catalyzed by Yb(OTf) 3 −SiO 2 (Scheme 1) and evaluation of their anticancer and c-Src kinase inhibitory activity. , using Yb(OTf) 3 −SiO 2 as a catalyst.…”

Recent advances in the synthesis and synthetic applications of Betti base (aminoalkylnaphthol) and bis-Betti base derivatives

“…It served as a highly efficient ligand for the asymmetric catalytic phenyl transfer to aromatic aldehydes and a variety of chiral diarylmethanols was prepared in toluene at À15 C for 15 h with high ee values (ee up to 99%) and in 87-95% yields (Scheme 22). 31 Total syntheses of enantiopure alkaloidal natural products (2S,6R)-dihydropinidine (as hydrochloride) and (2S,6R)-isosolenopsins (as hydrochlorides) (45) were achieved in four steps and in 80-82% total yields by using a synthetic strategy involving the formation and cleavage of 1,3-oxazinane. (S)-Betti base proved to be an excellent chiral auxiliary and a novel Pd/C-catalyzed N-debenzylation straightforwardly to amine hydrochloride in the presence of CH 2 Cl 2 was developed (Scheme 23).…”

Agar: a novel, efficient, and biodegradable catalyst for the one-pot three-component and green synthesis of 2,3-dihydroquinazolin-4(1H)-one, 4H-pyrimidobenzothiazole and 2-aminobenzothiazolomethylnaphthol derivatives

“…The crude product was recrystallized from ethanol to afford the pure 1-((benzo[d]thiazol-2-ylamino)(aryl)-methyl)naphthalen-2-ol derivatives. The desired pure products were characterized by comparison of their physical data (melting points, IR and 1 H NMR) with those of known compounds in the literature [37][38][39].…”