The ever increasing cases of microbial resistance pose a major threat to the scientific community and therefore the need for discovery and development of newer antimicrobial agents with novel mode of action is becoming critical. One of the ways to tackle this herculean problem is to generate hybrid molecules by combining two or more bioactive heterocyclic moieties in a single molecular platform. The review here describes published results of our research group's endeavors towards development of potential new and safe antimicrobial agents with better effectiveness by using the hybrid approach. In the present review article the landscaping of heterocycles like 4-thiazolidinones, benzimidazole and quinoline are described. Compounds displaying two of more fold antimicrobial activity are included in the review.

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An efficient synthesis of 1‐(benzothiazolylamino)methyl‐2‐naphthols has been developed in water by one‐pot condensation of 2‐naphthol, aldehydes and 2‐aminobenzothiazole catalyzed by sodium dodecyl sulfate. Advantages of the methodology include a very short reaction time, excellent yields and catalytic use of the sodium dodecyl sulfate.

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in Wiley Online Library (wileyonlinelibrary.com).Isomerization of 2 0 -hydroxychalcone and 2 0 -aminochalcone have been investigated using ytterbium(III) trifluromethanesulfonate {Yb(OTf) 3 } (30 mol %) as Lewis acid catalyst in [bmim] [BF 4 ] ionic liquid. The effect of different metal triflates as Lewis acid, catalyst loading and reaction media was studied for this isomerization reaction. Advantages of the methodology include short reaction time, excellent yields, catalytic use of Lewis acid, and recovery and reuse of the catalyst.Scheme 2. A plasible mechanism for isomerization of 2 0 -hydroxychalcones and 2 0 -aminochalcones. 1358Vol 48