SOFT CORAL (Sinularia sp.) EXTRACTS WITH ANTIBACTERIAL ACTIVITY

Abstract

There is a growing need for new antibacterial agents, in particular because many antibiotics are becoming ineffective due to the emergence of resistant bacterial strains. Soft corals of the Genus Sinularia, Family Alcyoniidae, have potential as a source of terpenoid and steroid compounds with antibacterial activity. These corals may vary in external morphology (shape, colour, size).The aim of this research was to identify extracted fractions with high antibacterial activity. Sinularia sp. specimens were extracted, fractionated based on solvent polarity, and tested for antibacterial bioactivity against pathogenic bacteria (Escherichia coli and Staphylococcus aureus). Antibacterial activity of the three fractions varied in strength. The dichloromethane fraction showed strong antibacterial activity, inhibiting S. aureus and E. coli growth at a concentration of 1 mg ml-1, while the ethyl acetate and ethanol fractions were effective at 10 mg ml-1 and 100 mg ml-1, respectively.

Anti-Trypanosomal Potential of The Red Sea Soft Coral Nephthea Mollis Supported by Metabolomic Profiling and Molecular Docking Studies

“…Similarly, the mass ion peak at m/z 240.172 for the predicted molecular formula C 14 H 24 O 3 , was dereplicated as the sesquiterpenes; chabranol (19), which was formerly characterized from Nephthea chabrolii [23]. Moreover, the mass ion peak at m/z 250.193 in agreement with the molecular formula C 16 H 26 O 2 was dereplicated as the sesquiterpenes; Methoxycolorenone (20) and/or 2-deoxy-7-O-methyllemnacarnol (21), the former was previously reported from Nephthea chabrolii [27], while the other was previously reported from Nephthea sp. [28].…”

Potensi dan Karakteristik Bakteri Simbion Karang Lunak Sinularia sp. sebagai Anti Bakteri Escherichia coli dari Perairan Pulau Gili Labak Madura Indonesia

“…Karang lunak Sinularia sp. yang diekstrak menggunakan fraksi ethanol juga mampu menghambat aktivitas bakteri Escherichia coli dengan membetuk diameter zona hambat sebesar 1,763±1,74 cm dan bakteri Staphylococcus aureus sebesar 1,743±2,29 cm Tanod et al, (2018). Beberapa hasil penelitian sebelumnya ini menunjukkan bahwa pemanfaatan ekstrak Sinularia sp.…”

AKTIVITAS ANTIBAKTERI EKSTRAK KARANG LUNAK Sinularia sp. DENGAN METODE BROTH-DILUTION

“…tumbuh dan berkembang optimal pada perairan bersuhu rata-rata tahunan 23-25°C, namun juga dapat mentoleransi suhu sampai 36-40°C dan salinitas sebesar 32-35 ‰. Habitat karang lunak umumnya dijumpai berada pada ekosistem terumbu karang (Tanod et al, 2018).…”

“…Konsentrasi hambat minimum dan konsentrasi bunuh minimum ditentukan dengan regresi linier berdasarkan metode Bloomfield (1991). Konsentrasi hambat minimum merupakan konsentrasi minimum yang diperlukan suatu agen antibakteri untuk menghambat pertumbuhan bakteri, sedangkan konsentrasi bunuh minimum merupakan konsentrasi minimum yang diperlukan suatu agen antibakteri untuk membunuh bakteri tersebut (Tanod et al, 2018). Dari hasil pengujian aktivitas antibakteri dibuat suatu persamaan garis linier antara konsentrasi ekstrak Sinularia sp.…”