Soil erosion occurs throughout the world and is a very serious problem especially in dry land areas of Ethiopia. Rural inhabitants try to develop some erosion control measures to reduce the negative impacts; however, the role of the women is not known and deserves to be studied to understand how land degradation processes are mitigated. Hence, the main goal of this study is to identify the determinant variables of women’s participation in soil and water conservation (SWC) practices in Shebel Berenta Woreda of Amhara Region in Ethiopia as a study case. Mixed-research method with sequential explanatory research design was employed through survey questionnaire, interview, key informant interview, focus group discussion, and field observation as data collection methods since 2019. Descriptive statistics and a binary logistic regression model were used to analyze the collected quantitative data. The result showed a significant number of respondents (86.4%) frequently participate in SWC, while 14.6% do not. Among those participated in SWC, 55.6%, 18.85 %, and 42.8% were highly involved in terracing, vegetation cover, and compost preparation as a part of SWC practices, respectively. In addition, 50.4% has participated in decision making about SWC, while 49.6% had not any involvement. The binary logistic regression model analysis shows widowed women (adjusted odds ratio [AOR] = 0.23, 95% confidence interval [CI] = 0.001, 0.814, P = .038); are able to read and write (AOR = 0.164, 95% CI = 0.027, 0.995, P = .049); have secondary education and higher levels (AOR = 0.139, 95% CI = 0.022, 0.874, P = .035). Similarly, those who do not have farm land (AOR = 0.263, 95% CI = 0.072, 0.964, P = .044); their lands do not show soil erosion (AOR = .043, 95% CI = 0.006, 0.296, P = .001); have not discussions about SWC (AOR = 0.142, 95% CI = 0.021, 0.952, P = .044); not receiving any advice to apply them (AOR = 0.145, 95% CI = 0.030, 0.694, P = .016) were variables that determine women’s participation in SWC. Therefore, the local government should work on awareness transference, providing new technologies, and building complete infrastructures to achieve better results of SWC.