Solidagenone from Solidago chilensis Meyen inhibits skin inflammation in experimental models

Abstract

Skin conditions such as psoriasis, atopic dermatitis and even cancer can trigger inflammatory mechanisms and may become chronic if left untreated. 1 Involving various cellular types such as nerve endings, keratinocytes, fibroblasts, mast cells, endothelial cells, macrophages and inflammatory cells (neutrophils, eosinophils, monocytes and lymphocytes), these dysfunctions represent a complex mobilization of defence systems, which release chemical mediators responsible for inflammation. 1,2 For example, histamine releases from mast cells and basophils increases blood supply, evoking hyperaemia that promotes vascular permeability and attracts inflammatory cells to the lesion site. Macrophages

The protective effect of solidagenone from Solidago chilensis Meyen in a mouse model of airway inflammation

“…The bioactive diterpene solidagenone was obtained from Solidago chilensis inflorescences using the methodology previously described by our group 6,7 . The plant material was cultivated in PAF‐FIOCRUZ (Agroecological Platform of Phytomedicines of Pharmaceutical Technology Institute; RJ, Brazil) (22.9407°S, 43.4046°W), confirmed and authenticated by Marcelo Neto Galvão, and one voucher specimen was deposited at HFV (Herbal Green Pharmacies), under number HFV 646.…”

“…All solvents and chemicals were of analytical grade. The structure and identification of SIS were evaluated by TLC, FTIR and UV spectroscopy and confirmed by MS and NMR analyses as described before 6,7 …”

Anti‐Inflammatory Activity and Chemical Analysis of Different Fractions from Solidago chilensis Inflorescence

“…Solidago chilensis Meyen (= Solidago microglossa) is a member of the Compositae family widely used in Brazilian folk medicine, as well as in other South American countries such as Chile, Argentina, Bolivia, and Paraguay. S. chilensis, popularly known as "Brazilian arnica," can exert multiple biological effects and is used as an antidepressant, gastroprotective, diuretic, burn treatment, skin diseases, anticancer, antiedematogenic, and anti-inflammatory [1][2][3][4][5][6][7][8][9].…”

“…chilensis is part of the Brazilian National List of Medicinal Plants of Interest to Unified National Health System, and extracts obtained from rhizomes and inflorescences have been produced for anti-inflammatory use [13]. Although the activity of S. chilensis is evidenced in the literature, there are few studies with enriched/characterized fractions or isolated compounds, especially concerning extracts obtained from the inflorescences, relating them to the anti-inflammatory and antinociceptive activities already well described in this plant species [9,14]. The generation of this knowledge can help in the identification of phytochemical markers that can be used in the future in the quality control of S. chilensis-based products.…”

Comparison of the use of Solidago chilensis (Arnica) and low-level laser therapy for the prevention of oral mucositis in patients submitted of head and neck radiotherapy and/or high toxicity chemotherapy

“…The use of medicinal plants in dentistry has increased significantly in recent years, because herbal medicines applied in the oral cavity have several important mechanisms of action (Baharvand et al, 2017). S. chilensis has been studied in its chemical and pharmacological properties, as well as used in folk medicine mainly in the treatment of inflammatory reactions such as rheumatism, pain and local edema, in addition to gastrointestinal stimulant, healing, antiseptic and burn treatment (Valverde-Soares et al, 2012;Valverde et al, 2021). This genus is known for its landscape and ornamental importance, in addition to presenting species with medicinal, aromatic potential, production of essential oils used in modern and popular medicine, manufacture of cosmetics, medicines, beverages and also antibacterial and anti-inflammatory properties (Sung et al, 1999).…”