Solubilisation of quercetin: Comparison of hyperbranched polymer and hydrogel

Althans, Daniel; Schrader, Philipp; Enders, Sabine

doi:10.1016/j.molliq.2014.03.028

Cited by 48 publications

(27 citation statements)

References 112 publications

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“…A value for the water-octanol partition coefficient of quercetin, log P(oct) = 2.06, is available [16], Althans et al [1] have determined the solubility in ethanol and Razmara et al [2] the solubility in methanol at 298 K. Then use of Cw allows log P(ethanol) and log P(methanol) to be deduced, and use of Kw allows log K values for gas to ethanol partition and gas to methanol partition to be deduced. In addition, we have equations on the lines of Eq.…”

Section: Resultsmentioning

confidence: 99%

“…Equations and coefficients for water-solvent and gas-solvent partitions, as log P and log K Althans et al [1] we chose not to use the these solubilities in our analysis but to predict the water-ethanol solubilities and then to compare the predictions with the experimental values. The required coefficients for partition between water and water-ethanol mixtures are in Table 2 [31].…”

Section: Tablementioning

confidence: 99%

“…Chebil et al [5] have also determined solubilities in a few nonaqueous solvents, but only at 323 K, and so we did not use these results, especially as Althans et al [1] have shown that quercetin in water decomposes at temperatures higher than 316 K..…”

Section: Tablementioning

confidence: 99%

“…Althans et al [1] have recently summarized the various measurements that have been made, and in Table 2 we list recorded solubilities in water at 298 K, as log Cw in units of mol/L. Although these determinations vary by more than three log units, it seems almost impossible to make a selection, especially given the very low solubility and the consequent experimental difficulty of the measurements.…”

Section: Introductionmentioning

confidence: 99%

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On the solubility of quercetin

Abraham

Acree

2014

Journal of Molecular Liquids

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There is considerable disagreement over the solubility of quercetin in water. Experimental values of log Cw with Cw in mol/L range from -2.52 to -5.89, a difference of over three log units. We have applied a methodology based on linear free energy equations for water-solvent and gassolvent partitions to study solubilities. These are related to partition coefficients through Ps = Cs/Cw where Cs and Cw are solubilities of a given solute in a solvent and in water. We find that known solubilities of quercetin in methanol and ethanol at 298 K and a known water-solvent partition coefficient can be accommodated in the same model if the water solubility at 298 K, as log Cw, is taken as -3.90, that is near to the middle of the range of experimental values. Our model successfully predicts solubilities of quercetin in water-ethanol mixtures near to the ethanol rich mixtures.

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Section: Resultsmentioning

confidence: 99%

Section: Tablementioning

confidence: 99%

Section: Tablementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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On the solubility of quercetin

Abraham

Acree

2014

Journal of Molecular Liquids

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“…28 Quercetin powder (Sigma-Aldrich, St. Louis, MO, USA) was directly added to 100% ethanol and water-bath heating at 37 C for 15 min to prepare four experimental primer solutions at concentrations of 0, 0.1, 0.5 and 1.0 wt%, respectively. The four primer solutions were designated as the following 4 groups and stored at 4 C for further investigation: Group 1: 100% ethanol (control group);…”

Section: Preparation Of Experimental Materialsmentioning

confidence: 99%

Quercetin as a simple but versatile primer in dentin bonding

Yang

Yan

et al. 2017

RSC Adv.

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Poor bonding stability remains the "Achilles' heel" of dentin bonding, a simple and effective approach to inhibit the activities of both exogenous collagenases and endogenous MMPs, and prevention of the growth of bacterial biofilm is therefore highly demanded. In the present study, a quercetin/ethanol solution was developed as a multifunctional primer to pretreat the dentin surface during adhesive restoration. The results showed that pretreatment with quercetin/ethanol solutions (0.5 and 1.0 wt%) on the dentin surface effectively preserved the bonding strength after one-month of collagenase aging (p < 0.05). Irrespective of aging, lower nanoleakage expression and less cohesive failure in dentin were observed in the quercetin-treated groups (p < 0.05). Compared with the control group, the in situ zymography test revealed that the 0.5 and 1.0 wt% quercetin-treated dentin effectively inhibited MMP activity, while their contact angles significantly increased. Live/dead bacterial staining and the MTT assay demonstrated that the 0.5 and 1.0 wt% quercetin groups exerted significant bactericidal effects while inhibiting biofilm growth of Streptococcus mutans (p < 0.05). We believe that a quercetin/ethanol solution might serve as a simple but versatile primer to provide dentists with a promising approach to obtain desirable bonding stability and to prevent secondary caries, thereby preventing the frequent replacement of resin-based restorations.

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Preparation and Physicochemical Properties of a Cysteine Derivative‐Loaded Deformable Liposomes in Hydrogel for Enhancing Whitening Effects

Jeong

Kim

et al. 2018

Euro J Lipid Sci & Tech

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Whitening materials cannot easily cross the skin barrier (stratum corneum) to reach melanocytes in the basal layer for inhibiting melanin production. This study aims to construct a novel deformable liposome using polyglyceryl‐3‐methylglucose distearate as an edge activator and a hydrogel containing hyaluronic acid (HA) and hydroxyethyl cellulose (HEC), as well as to investigate the synergistic effect of this system on the delivery of a cysteine derivative, methyl‐2‐acetylamino‐3‐(4‐hydroxyl‐3,5‐dimethoxybenzoylthio)propanoate (MP) as a whitening agent. The optimized deformable liposome (DL2) contains 10% edge activator and has a particle size of 78.2 ± 2.7 nm, a zeta potential of −29.9 ± 1.8 mV, a polydispersity index of 0.248, and an entrapment efficiency of 90.7 ± 1.7%. MP‐loaded DL2 has higher stability and deformability than DL2 without MP, as well as exerting a higher whitening effect than that observe with MP alone. In addition, MP‐loaded DL2 is incorporated into a hydrogel in a dual drug‐delivery system and the stability after hydrogel incorporation is evaluated. In Franz cells, the MP‐loaded deformable liposome‐hydrogel complex shows the highest skin permeation and penetration of MP. Practical Applications: In general, it is very difficult for whitening agents to penetrate a skin layer for reducing skin pigmentation. It is important to transfer whitening agents to the basal layer without causing physical damage to the skin. Deformable liposomes containing 10% polyglyceryl‐3‐methylglucose distearate in a hydrogel complex maximize the skin permeation of a cysteine derivative as a whitening agent. This finding indicates that the deformable liposome‐hydrogel complex is a potential delivery system for treatment of skin hyperpigmentation. The penetration mechanism of drugs in the skin by deformable liposome‐hydrogel complexes is as follows: Hydrogel hydrates stratum corneum to secure the route of drugs or nanocarrier permeation. polyglyceryl‐3‐methylglucose distearate as an edge activator enhances the fluidity of the stratum corneum lipid layer and the deformability of liposome. The edge activator‐based deformable liposomes pass through the stratum corneum stably.

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Solubilisation of quercetin: Comparison of hyperbranched polymer and hydrogel

Cited by 48 publications

References 112 publications

On the solubility of quercetin

On the solubility of quercetin

Quercetin as a simple but versatile primer in dentin bonding

Preparation and Physicochemical Properties of a Cysteine Derivative‐Loaded Deformable Liposomes in Hydrogel for Enhancing Whitening Effects

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