Solubility Measurement and Correlation of Doxycycline Hyclate in 10 Pure Solvents and Mixtures Solvents at 278.15–323.15 K

Abstract

The solid−liquid phase equilibrium solubility of doxycycline hyclate (DH) in 10 pure organic solvents and cosolvent mixtures DMF (1) + ethanol (2), DMSO (1) + ethanol (2) and acetone (1) + ethanol (2) at a temperature range from 278.15 to 323.15 K was measured and discussed. The results indicated that the experimental mole fraction (x) of DH in 10 neat solvents followed this order: acrylic acid > acetic acid > 1-butanol > 1-pentanol > tetrahydrofuran > isobutyl alcohol > isopropyl alcohol> propanoic acid > acetone > acetonitrile, and temperature affected obviously the solubility especially in acetic acid. Moreover, the experimental mole fraction (x) of DH increased with mass concentration rising of DMF or DMSO in DMF (1) + ethanol (2) or DMSO (1) + ethanol (2), and decreased gradually with mass concentration rising of acetone in acetone (1) + ethanol (2). The experimental solubility in all solvents was correlated better by the modified Apelblat model according to lower values of RAD and RMSD.

Solubility Behavior of N-Carbobenzoxy-l-2-phenylglycine in 11 Pure and a Binary Ethanol + Water Solvent Systems at 283.15–323.15 K

“…The Apel-J-A model (eq ) is a three-dimensional (3D) model (composed of the M-Apel model and Jouyban–Acree model), which can describe the relationship among temperature, solvent composition, and solubility. − …”

Equilibrium Solubility of 18β-Glycyrrhetinic Acid in 12 Pure Solvents: Determination, Correlation, and Hansen Solubility Parameter

“…The solubility of GA in DMF was higher than in alcohols or ester solvents because of the functional group −NH 2 in GA and DMF. In a word, the solubility of GA could not be elaborated by HSP and solvent polarity well because solubility might be affected by multiple factors, such as solute–solvent molecular interaction, solvent structure, solvent polarity, hydrogen bonding, and HSP. ,,− …”

“…Solid–liquid solubility data of GA in 12 pure organic solvents were determined using the static equilibrium method by previous work. − First, excess GA and 40 mL of solvent were added in a double-jacketed glass container. The glass container equipped was placed in a thermostatic water bath (Shanghai Bilon Instrument Co., Ltd., China) equipped with an electromagnetic stirrer.…”

Fabrication of HKUST-1/ZnO/SA nanocomposite for Doxycycline and Naproxen adsorption from contaminated water

“…This group of drugs is found within the sewer and most aquatic environments and different soil levels( Czech et al, 2021 ). The water solubility of Naproxen and doxycycline is 15900 and 50000 μg/L, respectively ( Mora and Mart í nez, 2007 ; Isidori et al, 2005 ; Bogardus and Blackwood, 1979 ; Shen et al, 2020 ). However, The WHO has confirmed the presence of the remaining 15–25 μg/L high-dose drugs in drinking water ( Organization, 2012 ).…”