Solubility of Ofloxacin in 1,2-Dichloromethane, Chloroform, Carbon Tetrachloride, and Water from (293.15 to 313.15) K

Abstract

The solubility of ofloxacin in 1,2-dichloromethane, chloroform, carbon tetrachloride, and water was measured by a gravimetrical method from (293.15 to 313.15) K under atmospheric pressure, and the solubility data were correlated against temperature. The solubility is at a minimum in water and a maximum in chloroform. Further, some thermodynamic parameters such as enthalpy, Gibbs energy, and entropy for dissolution have also been evaluated. For 1,2-dichloromethane and chloroform, enthalpy, Gibbs energy, and entropy values are very close and lower than those for carbon tetrachloride and water.

Solubility of norfloxacin and ofloxacin in supercritical carbon dioxide

“…Norfloxacin and ofloxacin are like most of the pharmaceutical compounds which typically have low solubility in scCO 2 , (usually inferior to 10 −4 in terms of mole fraction) due to their high molecular weight and polarity [34]. Although no experimental data was found in the literature for the solubility of these compounds in scCO 2 , their solubility in other common solvents has been reported [16,[35][36][37]. According to Zhang and Wang [35] the solubility of ofloxacin in water is higher than that measured for norfloxacin, indicating that the former is highly polar and consequently less soluble in scCO 2 as observed in this work.…”