Solvency and Hydrogen Bonding Interactions in Nonaqueous Systems

Higuchi, Takeru; Richards, John H.; Davis, S.S.; Kamada, Aiko; Hou, Jiancheng; Nakano, Masahiro; Nakano, Naomi I.; Pitman, Ian H.

doi:10.1002/jps.2600580603

Cited by 31 publications

(16 citation statements)

References 61 publications

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“…While the fact that these systems can he fit with solvation models does not. prove conclusively that the solubility changes are due largely to specific interactions, the Kl:l values obtained from the solubility data are consistent with what is expected from a consideration of the relative hydrogen-donating and hydrogen-accepting abilities of the respective molecules (8). A brief comparison of the solubility data in Table I provides a qualitative indication of the importance of hydrogen honding in determining relative solubilities.…”

Section: Resultssupporting

confidence: 66%

“…These phenols are listed in order of decreasing acidity and also decreasing hydrogen-donating ahility based on literature data (8).…”

Section: Resultsmentioning

confidence: 99%

“…Empirical correlations of equilibrium data based on linear free energy relationships were applied previously in hydtogen-bonded systems (8,26) constants in nonpolar media have not been determined, a direct correlation with acidity under the same solvent conditions is impossible., Figure 5 also shows the plot of the same values of log K1:l uersus Higuchi's h d values (8), which were derived from both thermodynamic and spectroscopic data. This correlation clearly suggests that the K1:l values reflect hydrogen-bonding interactions.…”

Section: Resultsmentioning

confidence: 99%

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Solubility of polar organic solutes in nonaqueous systems: Role of specific interactions

Anderson

Rytting

Higuchi

1980

Journal of Pharmaceutical Sciences

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Section: Resultssupporting

confidence: 66%

“…These phenols are listed in order of decreasing acidity and also decreasing hydrogen-donating ahility based on literature data (8).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Solubility of polar organic solutes in nonaqueous systems: Role of specific interactions

Anderson

Rytting

Higuchi

1980

Journal of Pharmaceutical Sciences

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“…3) They studied on solvency and hydrogen bonding interactions in nonaqueous systems. 4) EŠects of solvent composition on molecular interactions were subjects of a few studies. 5,6) Because of importance in clinical practice, more emphasis was placed on mechanisms of interactions in aqueous solutions.…”

Section: Reviews Of Research Work Basic Studies On Interactions Of Omentioning

confidence: 99%

From Physical Pharmacy to Clinical Pharmacology

Nakano

2005

YAKUGAKU ZASSHI

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Research works on molecular interactions in solutions were carried out at School of Pharmacy, the University of Wisconsin under the direction of Prof. T. Higuchi and at Faculty of Pharmaceutical Sciences, Kyoto University under the direction of Prof. H. Sezaki. Studies on permeation of drugs through polymer membranes were carried out at Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada and at Pharmaceutical Chemistry Research Laboratories at Food and Drug Directorate, Department of Health and Welfare, Canada. Studies on modiˆcation of delivery patterns by means of pharmaceutical approaches were carried out at Faculty of Pharmaceutical Sciences, Hokkaido University. Topics related to modiˆcation of drug delivery patterns include employment of amorphous forms such as ground mixture with micro-crystalline cellulose and coprecipitate with polyvinylpyrrolidone, use of biodegradable polymers such as polylactic acid and polycarbonates, gel-forming materials such as konjac, agar and hydroxypropylcellulose, and physicochemical systems such as complexation. Works related to drug delivery and disposition of drugs in humans were carried out at Department of Pharmacy, Kumamoto University Hospital. Topics related to drug delivery in humans include injections containing anticancer drugs for intra-arterial administration, lidocaine gels for dermal anesthesia, glucagon solution for nasal administration. Topics related to disposition of drugs in humans include clinical pharmacokinetic studies in infants and elderly and medical uses of adsorbents.

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“…Keyphrases 5-Aza-2'-deoxycytidine-analysis of chemical stability using high-performance liquid chromatography 0 Antileukemic agents-5-aza-2'-deoxycytidine, analysis of chemical stability using high-performance liquid chromatography 0 High-performance liquid chromatography-analysis of chemical stability of 5-aza-2'-deoxycytidine 5-Aza-2'-deoxycytidine (I), a nucleoside antimetabolite, is a very active antileukemic agent in mice (1, 2) and a potent cytotoxic agent against neoplastic cells in uitro (2,3). This antimetabolite is related to 5-azacytidine, an agent currently used in the clinical treatment of acute leukemia (4).…”

mentioning

confidence: 99%