Some processes concerned with the secretion of sodium, bromide and chloride in saliva

Burgen, A. S. V.; Terroux, Kathleen G.

doi:10.1113/jphysiol.1963.sp007287

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…This is approximately twice the estimated plasma volume for sheep. Transepithelial chloride movement is a driver of saliva production; however, the predominant chloride channels in salivary acinar cells favour Br secretion over chloride, with Br secreted in saliva at high concentrations . Given the large, but fluctuating volume of saliva production and the selective uptake of Br by salivary glands, it is possible that the fluctuations in serum Br concentration simply reflect the variation in saliva production at the time of sampling.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of bromide in adult sheep following oral and intravenous administration

2015

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When administered PO, bromide in sheep has a long half-life (t½ ) of approximately 14 days, with good bioavailability. Potassium bromide is a readily available, affordable salt with a long history of medical use as an anxiolytic, sedative and antiseizure therapy in other species. There are a number of husbandry activities and flock level neurological conditions, including perennial ryegrass toxicosis, in which bromide may have therapeutic or prophylactic application.

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Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of bromide in adult sheep following oral and intravenous administration

2015

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“…from the extracellular fluid to the duct lumen. Isotope studies Seeman 1958 andBurgen, Terroux andGonder 1959) have shown that the duct M-alls in stimulated glands are highly permeable to sodium.…”

Section: Transient Concentrationsmentioning

confidence: 99%

Excretion of Sodium and Potassium in Cat Submandibular Saliva

Petersen

Poulsen

1967

Acta Physiologica Scandinavica

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~ PETERSES, 0. H. and J. H. POULSEN. Excretion o f sodium and potassium in cat submaildibular saliva. Acta physiol. scand. 1967. 70. 158-167. The concentrations of ions in the saliva vary with the secretory rate. Different results concerning sodium concentration in relation to flow rate have been found by different investigators. In the present work secretion was elicited by chorda stimulation and the concentrations of sodium and potassiuni in the saliva were determined by flame photometry. The sodium concentrations in the first samples of cat submandibular saliva taken from a previously resting gland were higher than thc sodium concentrations in samples taken later at the same secretory rate. The maximal differencr in concentration between transient and steady state sample was about 50 meq/l. Steady state concentrations of sodium increased proportionally to the flow rate except at low flow rates where \odium concentrations were greater than expected on the basis of thir relation. Steady statr concentrations of potassium were independent of the secretory rate when this was higher than 100 p1;min;g gland, with a value of about 10 meq/l. Below this flow rate the potassium Concentration rose, first slightly and then steeply, when flow rate decreased, and reached values of more than 100 nieq,'l at secretory rates of about 2 pl/min/g gland.

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Transport in Salivary and Salt Glands

Young¹,

Lennep²

1979

Transport Organs

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Some processes concerned with the secretion of sodium, bromide and chloride in saliva

Cited by 4 publications

References 10 publications

Pharmacokinetics of bromide in adult sheep following oral and intravenous administration

Pharmacokinetics of bromide in adult sheep following oral and intravenous administration

Excretion of Sodium and Potassium in Cat Submandibular Saliva

Transport in Salivary and Salt Glands

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