Sorption/Desorption of Lincomycin from Three Arid-Region Soils

Abstract

The antibiotic lincomycin is commonly found in treated municipal waste water and in waste from swine and poultry production. Environmental disposal of these wastes has the potential to introduce a significant mass of lincomycin into the ecosystem. In the present study, a series of sorption and desorption experiments were conducted to determine the potential mobility of lincomycin in soils from arid environments. Sorption and desorption isotherms were obtained for lincomycin using three different soils. Isotherms were fit to the Freundlich equation. Adsorption of lincomycin was found to have a of 11.98 for a biosolid-treated soil (1.58% OC) and a of 210.15 for a similar unamended soil (1.42% OC). It was also found that for a low-organic-content soil the was 5.09. The differences in adsorption can be related to the soil pH and the pKa of lincomycin (7.5-7.8). When the soil solution pH is below the pKa, the cationic species of lincomycin dominates, resulting in increased water solubility. Interaction with the cation exchange complex is minimal due to a high solution cation concentration (Ca and Na). Desorption isotherms also indicate that when the solution pH is lower than the pKa, retention of lincomycin is reduced. Our results indicate that the mobility of lincomycin in these arid region soils is dependent on soil pH.

Persistence of the antimicrobials lincomycin, chlortetracycline, and sulfamethazine in prairie wetlands

“…Although susceptibility of the three antimicrobials to microbial degradation in wetland water might be indicated by their half‐lives in manure‐amended soil (chlortetracycline = 24 d, Carlson & Mabury, ; lincomycin = 18.4 d, Kuchta et al., ; sulfamethazine = 18.0 d, Accinelli et al., ), their persistence in soil does not reflect the decreasing order of their corresponding DT 50 values (lincomycin > sulfamethazine > chlortetracycline) in wetland water. The greater persistence of chlortetracycline in soil most likely reflects its lower water solubility (0.6 g L −1 ) and higher soil sorption coefficient (282–2608 L kg −1 ; Chee‐Sanford et al., ) versus corresponding values for lincomycin (0.927 g L −1 , Lissemore et al., ; 5–210 L kg −1 , Williams, Watson, Nelson, & Walker, ) and sulfamethazine (1.5 g L −1 ; 0.6–3.1 L kg −1 , Chee‐Sanford et al., ).…”

“…Although none of the rainfalls during the study periods resulted in runoff, rain in 2004 (16.0 mm) and 2005 (12.5 mm) would have diluted antimicrobial concentrations in the wetlands; however, some or all the dilution may have been offset by evapotranspiration. Partitioning to sediments was probably minor for lincomycin ( K d [soil adsorption coefficient] = 5–210 L kg −1 ; Williams et al., ) and sulfamethazine ( K d = 0.6–3.1 L kg −1 ; Chee‐Sanford et al., ) because they are not strongly sorbed to soil. Partitioning to sediments, however, may account, in part, for the rapid dissipation of chlortetracycline ( K d = 282–2608 L kg −1 ; Chee‐Sanford et al., ) observed in Wetland 3.…”

Not All Antibiotic Use Practices in Food-Animal Agriculture Afford the Same Risk

“…For example, fluoroquinolones and sulfonamides adsorbed better to manure with a high organic matter content, whereas oxytetracycline and tylosin were less responsive to the organic matter content (Marengo et al, 1997;Loke et al, 2002). Other antibiotics are affected by cation exchange capacity (ciprofloxacin adsorbs well to soil with high effective cation exchange capacity [Carrasquillo et al, 2008]), pH, or other soil properties Strock et al, 2005;Kim et al, 2012;Leal et al, 2013;Williams et al, 2013). Lincomycin sorption is dependent on soil pH (Williams et al, 2013), and oxytetracycline adsorption to clay minerals and humic substances is dependent on the pH (Figueroa et al, 2004).…”

Manure Injection Affects the Fate of Pirlimycin in Surface Runoff and Soil

“…Cation exchange was the primary mechanism for soil sorption of lincomycin, a first-generation lincosamide, but as pH decreased, mobility of lincomycin increased (Wang et al, 2009). Also, cation exchange was dependent on cation concentrations in the soil solution (Wang et al, 2009;Williams et al, 2013). In a study by USFDA (1993), soil organic carbon-water partitioning coefficient (K OC ) values were variable among three soil types, ranging from tightly bound to slightly bound in a silt loam, clay loam, or silty clay loam soil.…”

“…After 7 d, the partition ratios increased to 175 and 75 L kg −1 in the surface runoff of the two treatments, respectively. Lincomycin soil/solution equilibrium was reached within 24 h when shaken at 17°C (Wang et al, 2009;Williams et al, 2013). Time between manure application and the first rainfall event could be very important in determining pirlimycin transport from agricultural fields.…”