Soy isoflavones and cholecalciferol reduce inflammation, and gut permeability, without any effect on antioxidant capacity in irritable bowel syndrome: A randomized clinical trial

Jalili, Mahsa; Vahedi, Homayoon; Hekmatdoost, Azita

doi:10.1016/j.clnesp.2019.09.003

Cited by 21 publications

(21 citation statements)

References 18 publications

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“…Of the twenty-eight included studies, twenty-five articles were randomised (24)(25)(26)(27)(28)34,(36)(37)(38)(39)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56) and only sixteen articles reported randomisation methods (24)(25)(26)(27)(28)34,(36)(37)(38)(39)(44)(45)(46)48,50,56) . Fifteen studies were double-blinded (24)(25)(26)(27)(28)(36)(37)(38)(39)(40)…”

Section: Systematic Reviewmentioning

confidence: 99%

“…The effect of soya intake on TNF-α level was evaluated in twenty-two studies (twenty-three effect sizes). Pooled analysis (39) þ þ þ þ þ þ þ Good Zhang et al (2017) (25) þ þ þ þ þ þ þ Good Nadadur et al (2016) (34) þ þ --þ þ þ Good Amanat et al (2018) (24) þ þ þ þ þ þ þ Good Giolo et al (2018) (46) þ þ þ þ þ þ þ Good Jalili et al (2019) (56) þ þ þ þ þ þ þ Good * The overall quality of each study was considered as good (>2 'þ' signs), fair (2 'þ' signs) or weak (<2 'þ' signs). demonstrated a significant reduction in TNF-α in the soya group compared with controls (Hedges' g -0•28; 95 % CI -0•49, -0•07).…”

Section: The Effect Of Soya and Soya Products On Tnf-αmentioning

confidence: 99%

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The effect of soya consumption on inflammatory biomarkers: a systematic review and meta-analysis of clinical trials

et al. 2020

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Inflammation is a major cause of chronic diseases. Several studies have investigated the effects of soy intake on inflammatory biomarkers; however, the results are equivocal. The aim of this study was to conduct a systematic review and meta-analysis of clinical trials that evaluated the effect of soy consumption on inflammatory biomarkers. Medline, Scopus, ISI Web of Science, and Google Scholar were systematically searched, up to and including May 2020, for clinical trials that evaluated the effects of soy and soy products on tumor necrosis factor α (TNF-α), Interleukin-6 (IL-6), Interleukin-2 (IL-2), Interleukin1-β (IL1-β), and Interferon gamma (IFN-γ) in adults. A random-effects method was used to calculate overall effects, and subgroup analyses were performed to discern probable sources of inter-study heterogeneity. A total of 28 clinical trials were included. Although soy consumption reduced TNF-α (Hedges’ g= −0.28; 95%CI: −0.49, −0.07), it had no significant effect on IL-6 (Hedges’ g= 0.07, 95% CI: −0.14, 0.28), IL-2 (MD= −1.38 pg/ml; 95%CI: −3.07, 0.31), IL1-β (MD= −0.02 pg/ml; 95%CI: −0.08, 0.03), and IFN-γ (MD= 1685.82 pg/ml; 95%CI: −1604.86, 4976.50). Subgroup analysis illustrated a reduction in TNF-α in in parallel designed studies, at dosages ≥100 mg of isoflavones, and in unhealthy subjects. The present study showed that high doses of isoflavones in unhealthy subjects may yield beneficial effects on TNF-α.

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Section: Systematic Reviewmentioning

confidence: 99%

Section: The Effect Of Soya and Soya Products On Tnf-αmentioning

confidence: 99%

The effect of soya consumption on inflammatory biomarkers: a systematic review and meta-analysis of clinical trials

et al. 2020

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“…In line with a limited but emerging understanding of inflammatory changes in IBS, there has been investigation into the inflammatory response in IBS following PP administration, with only two studies exploring inflammatory markers. Consumption of 40 mg soy isoflavones results in a significant reduction in TNF-α and lower levels of NF-κB [58], but supplementation of 20 mg polydatin combined with 200 mg palmitoylethanolamide supplementation did not affect mast cell count over time [56].…”

Section: (Poly)phenols and Inflammatory Markers In Inflammatory Bowel Disease And Irritable Bowel Syndromementioning

confidence: 92%

“…The irritable bowel syndrome severity scoring system (IBS-SSS) is a five-item questionnaire that explores questions about gastrointestinal symptoms and the interference of IBS with quality of life [82]. Forty mg of soy isoflavones daily for 6 weeks did not impact IBS-SSS [59]; however, when combined with vitamin D 50,000 IU biweekly, it resulted in a significantly lower score [57,58]. Eighty-four mg curcumin supplement in combination with fennel essential oil for 30 days [62] and 1000 mg ginger for 28 days [64] also significantly reduced IBS-SSS.…”

Section: (Poly)phenols and Symptoms In Inflammatory Bowel Disease And Irritable Bowel Syndromementioning

confidence: 99%

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(Poly)phenols in Inflammatory Bowel Disease and Irritable Bowel Syndrome: A Review

2021

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(Poly)phenols (PPs) may have a therapeutic benefit in gastrointestinal (GI) disorders, such as irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD). The aim of this review is to summarise the evidence-base in this regard. Observational evidence does not give a clear indication that PP intake has a preventative role for IBD or IBS, while interventional studies suggest these compounds may confer symptomatic and health-related quality of life improvements in known patients. There are inconsistent results for effects on markers of inflammation, but there are promising reports of endoscopic improvement. Work on the effects of PPs on intestinal permeability and oxidative stress is limited and therefore conclusions cannot be formed. Future work on the use of PPs in IBD and IBS will strengthen the understanding of clinical and mechanistic effects.

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The effect of soy isoflavones and soy isoflavones plus soy protein on serum concentration of tumor necrosis factor‐α? A systematic review and meta‐analysis of randomized controlled trials

Hariri

Baradaran

Gholami

2021

Phytotherapy Research

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In this study, we summarized the effect of soy isoflavones and soy isoflavones plus soy protein on serum concentration of tumor necrosis factor-alpha (TNF-α) among adult participants. We systematically searched Scopus, ISI Web of Science, Cochrane Library, PubMed, and clinicaltrials.gov for articles published up to May 2020. Effect size was calculated by mean change from baseline of TNF-α concentrations and its standard deviation (SD) for intervention and comparison groups. If the heterogeneity test was statistically significant, DerSimonian and Laird random effects model was used to estimate the summary of the overall effects and its heterogeneity. Nineteen and fourteen randomized clinical trials were included in our systematic review and meta-analysis, respectively. The result of overall effect size indicated a nonsignificant effect in serum concentration of TNF-α following soy isoflavones intake (WMD = 0.2 pg/ml, 95% CI: −0.13, 0.53; p = .226) and the combination of soy isoflavones and soy protein intake (WMD = 0.02 pg/ml, 95% CI: −0.02, 0.06; p = .286). Subgroup analyses revealed no significant change in circulatory levels of TNF-α following soy isoflavones plus soy protein intake. In conclusion, the present systematic review and meta-analysis found insufficient evidence that soy isoflavones or the combination of soy isoflavones and soy protein significantly reduce serum concentration of TNF-α.

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Soy isoflavones and cholecalciferol reduce inflammation, and gut permeability, without any effect on antioxidant capacity in irritable bowel syndrome: A randomized clinical trial

Cited by 21 publications

References 18 publications

The effect of soya consumption on inflammatory biomarkers: a systematic review and meta-analysis of clinical trials

The effect of soya consumption on inflammatory biomarkers: a systematic review and meta-analysis of clinical trials

(Poly)phenols in Inflammatory Bowel Disease and Irritable Bowel Syndrome: A Review

The effect of soy isoflavones and soy isoflavones plus soy protein on serum concentration of tumor necrosis factor‐α? A systematic review and meta‐analysis of randomized controlled trials

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