Spatially fractionated GRID radiation treatment of advanced neck disease associated with head and neck cancer

Impact of dose size in single fraction spatially fractionated (grid) radiotherapy for melanoma

“…(3) the LQ model has well documented predictive properties for fractionation/dose-rate effects in the laboratory; (4) the LQ model has been repeatedly validated and it would be reasonable to use it for doses up to ∼18 Gy per fraction; (5) to date, there is no evidence of problems when LQ has been used clinically. However, in order to validate Brenner's assertion and further validate the radiobiologic modeling results, a MLQ model-introduced by Guerrreo and Li 21 -was used to estimate the surviving fractions of the same melanoma cell lines after grid therapy, in addition to the classical LQ model.…”

“…The usefulness of spatially fractionated (grid) radiotherapy for treating bulky tumors has been recognized for at least two decades. [1][2][3][4][5] As reported by Zwicker et al 6 and Zhang et al, 7 grid therapy takes advantage of the fact that in general normal cells have better repair capabilities than tumor cells. When normal cells are spared in grid therapy, those underirradiated areas can serve as centers of regrowth of normal tissues.…”

“…In addition, both theoretical studies and clinical outcomes have revealed that a course of open field conventional radiotherapy is needed to fully control tumor growth after grid therapy. 3,5,8 This is primarily because the effective dose delivered by single fraction grid therapy is not large enough to achieve full control of tumor growth, even though damage to normal cells is reduced, and/or selective killing of tumor cells has been achieved via the grid field.…”

Collimator design for experimental minibeam radiation therapy

“…One such therapy is microbeam radiation therapy ͑MRT͒. [4][5][6][7][8] The concept of MRT is similar to GRID therapy [9][10][11] in that healthy tissue is spared by applying discretely spaced beams as opposed to a continuous solid beam over the same volume. With MRT, several narrow beams ͑tens of micrometers in width, spaced hundreds of micrometers apart͒ are delivered through the tumor.…”

Spatially fractionated (GRID) radiation therapy using proton pencil beam scanning (PBS): Feasibility study and clinical implementation

“…5,6 Clinical results have confirmed that GRID therapy is well tolerated by patients and is very effective in treating bulky tumors at various sites. [7][8][9] The standard delivery method for GRID therapy involves using collimating blocks with a distinctive transmission pattern mounted on a linear accelerator (Linac). 10,11 The blocks have equally spaced holes that allow full photon intensity transmission.…”